The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review
Recent studies have shown the positive association between increased circulating BCAAs (valine, leucine, and isoleucine) and insulin resistance (IR) in obese or diabetic patients. However, results seem to be controversial in different races, diets, and distinct tissues. Our aims were to evaluate the...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/2794591 |
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| author | Xue Zhao Qing Han Yujia Liu Chenglin Sun Xiaokun Gang Guixia Wang |
| author_facet | Xue Zhao Qing Han Yujia Liu Chenglin Sun Xiaokun Gang Guixia Wang |
| author_sort | Xue Zhao |
| collection | DOAJ |
| description | Recent studies have shown the positive association between increased circulating BCAAs (valine, leucine, and isoleucine) and insulin resistance (IR) in obese or diabetic patients. However, results seem to be controversial in different races, diets, and distinct tissues. Our aims were to evaluate the relationship between BCAA and IR as well as later diabetes risk and explore the phenotypic and genetic factors influencing BCAA level based on available studies. We performed systematic review, searching MEDLINE, EMASE, ClinicalTrials.gov, the Cochrane Library, and Web of Science from inception to March 2016. After selection, 23 studies including 20,091 participants were included. Based on current evidence, we found that BCAA is a useful biomarker for early detection of IR and later diabetic risk. Factors influencing BCAA level can be divided into four parts: race, gender, dietary patterns, and gene variants. These factors might not only contribute to the elevated BCAA level but also show obvious associations with insulin resistance. Genes related to BCAA catabolism might serve as potential targets for the treatment of IR associated metabolic disorders. Moreover, these factors should be controlled properly during study design and data analysis. In the future, more large-scale studies with elaborate design addressing BCAA and IR are required. |
| format | Article |
| id | doaj-art-c53db9c20ecf4698a8a095cbc5f902a3 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-c53db9c20ecf4698a8a095cbc5f902a32025-02-03T05:48:27ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/27945912794591The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic ReviewXue Zhao0Qing Han1Yujia Liu2Chenglin Sun3Xiaokun Gang4Guixia Wang5Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, ChinaHospital of Orthopedics, The Second Hospital of Jilin University, Changchun 130021, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, ChinaRecent studies have shown the positive association between increased circulating BCAAs (valine, leucine, and isoleucine) and insulin resistance (IR) in obese or diabetic patients. However, results seem to be controversial in different races, diets, and distinct tissues. Our aims were to evaluate the relationship between BCAA and IR as well as later diabetes risk and explore the phenotypic and genetic factors influencing BCAA level based on available studies. We performed systematic review, searching MEDLINE, EMASE, ClinicalTrials.gov, the Cochrane Library, and Web of Science from inception to March 2016. After selection, 23 studies including 20,091 participants were included. Based on current evidence, we found that BCAA is a useful biomarker for early detection of IR and later diabetic risk. Factors influencing BCAA level can be divided into four parts: race, gender, dietary patterns, and gene variants. These factors might not only contribute to the elevated BCAA level but also show obvious associations with insulin resistance. Genes related to BCAA catabolism might serve as potential targets for the treatment of IR associated metabolic disorders. Moreover, these factors should be controlled properly during study design and data analysis. In the future, more large-scale studies with elaborate design addressing BCAA and IR are required.http://dx.doi.org/10.1155/2016/2794591 |
| spellingShingle | Xue Zhao Qing Han Yujia Liu Chenglin Sun Xiaokun Gang Guixia Wang The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review Journal of Diabetes Research |
| title | The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review |
| title_full | The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review |
| title_fullStr | The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review |
| title_full_unstemmed | The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review |
| title_short | The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review |
| title_sort | relationship between branched chain amino acid related metabolomic signature and insulin resistance a systematic review |
| url | http://dx.doi.org/10.1155/2016/2794591 |
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