Physical modulation and peripheral nerve regeneration: a literature review
Abstract Peripheral nerve injury (PNI) usually causes severe motor, sensory and autonomic dysfunction. In addition to direct surgical repair, rehabilitation exercises, and traditional physical stimuli, for example, electrical stimulation, have been applied in promoting the clinical recovery of PNI f...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-12-01
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| Series: | Cell Regeneration |
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| Online Access: | https://doi.org/10.1186/s13619-024-00215-9 |
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| _version_ | 1850103115970248704 |
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| author | Xiangwen Zhai Yuzhong Wang |
| author_facet | Xiangwen Zhai Yuzhong Wang |
| author_sort | Xiangwen Zhai |
| collection | DOAJ |
| description | Abstract Peripheral nerve injury (PNI) usually causes severe motor, sensory and autonomic dysfunction. In addition to direct surgical repair, rehabilitation exercises, and traditional physical stimuli, for example, electrical stimulation, have been applied in promoting the clinical recovery of PNI for a long time but showed low efficiency. Recently, significant progress has been made in new physical modulation to promote peripheral nerve regeneration. We hereby review current progress on the mechanism of peripheral nerve regeneration after injury and summarize the new findings and evidence for the application of physical modulation, including electrical stimulation, light, ultrasound, magnetic stimulation, and mechanical stretching in experimental studies and the clinical treatment of patients with PNI. |
| format | Article |
| id | doaj-art-c536fc564d0746a69d09d1728e2c010f |
| institution | DOAJ |
| issn | 2045-9769 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Cell Regeneration |
| spelling | doaj-art-c536fc564d0746a69d09d1728e2c010f2025-08-20T02:39:37ZengSpringerOpenCell Regeneration2045-97692024-12-0113111310.1186/s13619-024-00215-9Physical modulation and peripheral nerve regeneration: a literature reviewXiangwen Zhai0Yuzhong Wang1College of Rehabilitation Medicine, Shandong University of Traditional Chinese MedicineDepartment of Neurology, Affiliated Hospital of Jining Medical UniversityAbstract Peripheral nerve injury (PNI) usually causes severe motor, sensory and autonomic dysfunction. In addition to direct surgical repair, rehabilitation exercises, and traditional physical stimuli, for example, electrical stimulation, have been applied in promoting the clinical recovery of PNI for a long time but showed low efficiency. Recently, significant progress has been made in new physical modulation to promote peripheral nerve regeneration. We hereby review current progress on the mechanism of peripheral nerve regeneration after injury and summarize the new findings and evidence for the application of physical modulation, including electrical stimulation, light, ultrasound, magnetic stimulation, and mechanical stretching in experimental studies and the clinical treatment of patients with PNI.https://doi.org/10.1186/s13619-024-00215-9Peripheral nerve injuryRegenerationElectrical stimulationPhototherapyMagnetic stimulationUltrasound therapy |
| spellingShingle | Xiangwen Zhai Yuzhong Wang Physical modulation and peripheral nerve regeneration: a literature review Cell Regeneration Peripheral nerve injury Regeneration Electrical stimulation Phototherapy Magnetic stimulation Ultrasound therapy |
| title | Physical modulation and peripheral nerve regeneration: a literature review |
| title_full | Physical modulation and peripheral nerve regeneration: a literature review |
| title_fullStr | Physical modulation and peripheral nerve regeneration: a literature review |
| title_full_unstemmed | Physical modulation and peripheral nerve regeneration: a literature review |
| title_short | Physical modulation and peripheral nerve regeneration: a literature review |
| title_sort | physical modulation and peripheral nerve regeneration a literature review |
| topic | Peripheral nerve injury Regeneration Electrical stimulation Phototherapy Magnetic stimulation Ultrasound therapy |
| url | https://doi.org/10.1186/s13619-024-00215-9 |
| work_keys_str_mv | AT xiangwenzhai physicalmodulationandperipheralnerveregenerationaliteraturereview AT yuzhongwang physicalmodulationandperipheralnerveregenerationaliteraturereview |