The global, regional, and national burden of oral cancer, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
Abstract Purpose This epidemiological study leverages data from the Global Burden of Disease (GBD) database spanning from 1990 to 2021 to analyze the global burden of oral cancer. The research aims to provide a comprehensive assessment of the age-standardized incidence rate (ASIR), age-standardized...
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| Format: | Article |
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Springer
2025-01-01
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| Series: | Journal of Cancer Research and Clinical Oncology |
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| Online Access: | https://doi.org/10.1007/s00432-025-06098-w |
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| author | Junmeng Wu He Chen Yingjun Liu Ruotong Yang Na An |
| author_facet | Junmeng Wu He Chen Yingjun Liu Ruotong Yang Na An |
| author_sort | Junmeng Wu |
| collection | DOAJ |
| description | Abstract Purpose This epidemiological study leverages data from the Global Burden of Disease (GBD) database spanning from 1990 to 2021 to analyze the global burden of oral cancer. The research aims to provide a comprehensive assessment of the age-standardized incidence rate (ASIR), age-standardized mortality rate (ASDR), and disability-adjusted life years (DALYs) for oral cancer, examining trends over three decades. Methods The study used age standardized rate (ASRs) as an indicator of oral cancer epidemiological data. Trend analysis uses estimated annual percentage change (EAPC) to track changes in oral cancer indicators. Results The study identifies a global increase in oral cancer incidence, mortality, and DALYs. From 1990 to 2021, the global incidence rate increased significantly from 3.26 (95% UI 3.14–3.41) to 5.34 (95% UI 4.94–5.70), the global mortality rate rose from 1.83 (95% UI 1.73–1.92) to 2.64 (95% UI 2.42–2.84), and the global estimate of DALYs increased from 55.05 (95% UI 52.38–57.97) to 74.44 (95% UI 67.50–80.44). High-risk regions include Palau and certain areas in Asia. Middle SDI regions show the most significant growth, while economically underdeveloped areas like parts of Africa show less significant trends. Conclusion The research underscores the need for heightened awareness, surveillance, and prevention efforts, especially in regions with high oral cancer incidence. Policymakers are urged to implement screening programs and public health education to combat the disease. |
| format | Article |
| id | doaj-art-c53573b04741441fb46b9a931ccf6e4b |
| institution | Kabale University |
| issn | 1432-1335 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Cancer Research and Clinical Oncology |
| spelling | doaj-art-c53573b04741441fb46b9a931ccf6e4b2025-02-02T12:07:11ZengSpringerJournal of Cancer Research and Clinical Oncology1432-13352025-01-01151211210.1007/s00432-025-06098-wThe global, regional, and national burden of oral cancer, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021Junmeng Wu0He Chen1Yingjun Liu2Ruotong Yang3Na An4Xi’an Medical UniversityDepartment of General Dentistry II, Peking University School and Hospital of StomatologyDepartment of General Dentistry II, Peking University School and Hospital of StomatologyDepartment of Epidemiology and Biostatistics, School of Public Health, Peking UniversityDepartment of General Dentistry II, Peking University School and Hospital of StomatologyAbstract Purpose This epidemiological study leverages data from the Global Burden of Disease (GBD) database spanning from 1990 to 2021 to analyze the global burden of oral cancer. The research aims to provide a comprehensive assessment of the age-standardized incidence rate (ASIR), age-standardized mortality rate (ASDR), and disability-adjusted life years (DALYs) for oral cancer, examining trends over three decades. Methods The study used age standardized rate (ASRs) as an indicator of oral cancer epidemiological data. Trend analysis uses estimated annual percentage change (EAPC) to track changes in oral cancer indicators. Results The study identifies a global increase in oral cancer incidence, mortality, and DALYs. From 1990 to 2021, the global incidence rate increased significantly from 3.26 (95% UI 3.14–3.41) to 5.34 (95% UI 4.94–5.70), the global mortality rate rose from 1.83 (95% UI 1.73–1.92) to 2.64 (95% UI 2.42–2.84), and the global estimate of DALYs increased from 55.05 (95% UI 52.38–57.97) to 74.44 (95% UI 67.50–80.44). High-risk regions include Palau and certain areas in Asia. Middle SDI regions show the most significant growth, while economically underdeveloped areas like parts of Africa show less significant trends. Conclusion The research underscores the need for heightened awareness, surveillance, and prevention efforts, especially in regions with high oral cancer incidence. Policymakers are urged to implement screening programs and public health education to combat the disease.https://doi.org/10.1007/s00432-025-06098-wOral cancerEpidemiologyGlobal Burden of DiseaseAge-standardized rateEstimated annual percent change |
| spellingShingle | Junmeng Wu He Chen Yingjun Liu Ruotong Yang Na An The global, regional, and national burden of oral cancer, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 Journal of Cancer Research and Clinical Oncology Oral cancer Epidemiology Global Burden of Disease Age-standardized rate Estimated annual percent change |
| title | The global, regional, and national burden of oral cancer, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 |
| title_full | The global, regional, and national burden of oral cancer, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 |
| title_fullStr | The global, regional, and national burden of oral cancer, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 |
| title_full_unstemmed | The global, regional, and national burden of oral cancer, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 |
| title_short | The global, regional, and national burden of oral cancer, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 |
| title_sort | global regional and national burden of oral cancer 1990 2021 a systematic analysis for the global burden of disease study 2021 |
| topic | Oral cancer Epidemiology Global Burden of Disease Age-standardized rate Estimated annual percent change |
| url | https://doi.org/10.1007/s00432-025-06098-w |
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