Strategies for Multiple Sequence Alignment
We present an overview of multiple sequence alignments to outline the practical consequences for the choices among different techniques and parameters. We begin with a discussion of the scoring methods for quantifying the quality of a multiple sequence alignment, followed by a discussion of the algo...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2002-03-01
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| Series: | BioTechniques |
| Online Access: | https://www.future-science.com/doi/10.2144/02323rv01 |
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| _version_ | 1850152681353510912 |
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| author | Hugh B. Nicholas Alexander J. Ropelewski David W. Deerfield |
| author_facet | Hugh B. Nicholas Alexander J. Ropelewski David W. Deerfield |
| author_sort | Hugh B. Nicholas |
| collection | DOAJ |
| description | We present an overview of multiple sequence alignments to outline the practical consequences for the choices among different techniques and parameters. We begin with a discussion of the scoring methods for quantifying the quality of a multiple sequence alignment, followed by a discussion of the algorithms implemented within a variety of multiple sequence alignment programs. We also discuss additional alignment details such as gap penalty and distance metrics. The paper concludes with a discussion on how to improve alignment quality and the limitations of the techniques described in this paper. |
| format | Article |
| id | doaj-art-c52d9258078648d7bdbd321b673f65f5 |
| institution | OA Journals |
| issn | 0736-6205 1940-9818 |
| language | English |
| publishDate | 2002-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | BioTechniques |
| spelling | doaj-art-c52d9258078648d7bdbd321b673f65f52025-08-20T02:25:54ZengTaylor & Francis GroupBioTechniques0736-62051940-98182002-03-0132357259110.2144/02323rv01Strategies for Multiple Sequence AlignmentHugh B. Nicholas0Alexander J. Ropelewski1David W. Deerfield21Carnegie Mellon University, Pittsburgh, PA, USA1Carnegie Mellon University, Pittsburgh, PA, USA1Carnegie Mellon University, Pittsburgh, PA, USAWe present an overview of multiple sequence alignments to outline the practical consequences for the choices among different techniques and parameters. We begin with a discussion of the scoring methods for quantifying the quality of a multiple sequence alignment, followed by a discussion of the algorithms implemented within a variety of multiple sequence alignment programs. We also discuss additional alignment details such as gap penalty and distance metrics. The paper concludes with a discussion on how to improve alignment quality and the limitations of the techniques described in this paper.https://www.future-science.com/doi/10.2144/02323rv01 |
| spellingShingle | Hugh B. Nicholas Alexander J. Ropelewski David W. Deerfield Strategies for Multiple Sequence Alignment BioTechniques |
| title | Strategies for Multiple Sequence Alignment |
| title_full | Strategies for Multiple Sequence Alignment |
| title_fullStr | Strategies for Multiple Sequence Alignment |
| title_full_unstemmed | Strategies for Multiple Sequence Alignment |
| title_short | Strategies for Multiple Sequence Alignment |
| title_sort | strategies for multiple sequence alignment |
| url | https://www.future-science.com/doi/10.2144/02323rv01 |
| work_keys_str_mv | AT hughbnicholas strategiesformultiplesequencealignment AT alexanderjropelewski strategiesformultiplesequencealignment AT davidwdeerfield strategiesformultiplesequencealignment |