Assessment of Salivary Adipokines Resistin, Visfatin, and Ghrelin as Type 2 Diabetes Mellitus Biomarkers
Type 2 diabetes mellitus (T2DM) is emerging as a metabolic epidemic worldwide. Pathologically, dysregulation of many biological pathways precedes hyperglycemia and the clinical diagnosis of T2DM. Changing trajectories along the process of T2DM development necessitates frequent measurement of biomark...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2018/7463796 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563245070680064 |
|---|---|
| author | Mythily Srinivasan Melinda L. Meadows Lisa Maxwell |
| author_facet | Mythily Srinivasan Melinda L. Meadows Lisa Maxwell |
| author_sort | Mythily Srinivasan |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM) is emerging as a metabolic epidemic worldwide. Pathologically, dysregulation of many biological pathways precedes hyperglycemia and the clinical diagnosis of T2DM. Changing trajectories along the process of T2DM development necessitates frequent measurement of biomarkers for early identification of at-risk individuals and successful prevention. Increase in circulating inflammatory adipokines has been suggested as predictive of T2DM. Human saliva is an easily accessible biospecimen amenable for painless frequent collection and possesses nearly 50% of serum proteome. In this study, we measured the adipokines resistin, visfatin, TNF-α, and ghrelin as markers for T2DM in unstimulated whole saliva (UWS) using specific assay kits. Resistin and visfatin concentrations were significantly higher in T2DM saliva. Although the concentration of acylated or unacylated ghrelin was lower in diabetic saliva, the decrease was not significant. Since resistin and visfatin are biomarkers integral to T2DM pathology, their salivary assessments may receive clinical acceptance. |
| format | Article |
| id | doaj-art-c52cfd09100949e8a084ea2cf1d092ad |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-c52cfd09100949e8a084ea2cf1d092ad2025-02-03T01:20:45ZengWileyBiochemistry Research International2090-22472090-22552018-01-01201810.1155/2018/74637967463796Assessment of Salivary Adipokines Resistin, Visfatin, and Ghrelin as Type 2 Diabetes Mellitus BiomarkersMythily Srinivasan0Melinda L. Meadows1Lisa Maxwell2Departments of Oral Pathology, Medicine and Radiology, Indiana University School of Dentistry, Indianapolis, IN, USAPreventive and Community Dentistry, Indiana University School of Dentistry, Indianapolis, IN, USAPreventive and Community Dentistry, Indiana University School of Dentistry, Indianapolis, IN, USAType 2 diabetes mellitus (T2DM) is emerging as a metabolic epidemic worldwide. Pathologically, dysregulation of many biological pathways precedes hyperglycemia and the clinical diagnosis of T2DM. Changing trajectories along the process of T2DM development necessitates frequent measurement of biomarkers for early identification of at-risk individuals and successful prevention. Increase in circulating inflammatory adipokines has been suggested as predictive of T2DM. Human saliva is an easily accessible biospecimen amenable for painless frequent collection and possesses nearly 50% of serum proteome. In this study, we measured the adipokines resistin, visfatin, TNF-α, and ghrelin as markers for T2DM in unstimulated whole saliva (UWS) using specific assay kits. Resistin and visfatin concentrations were significantly higher in T2DM saliva. Although the concentration of acylated or unacylated ghrelin was lower in diabetic saliva, the decrease was not significant. Since resistin and visfatin are biomarkers integral to T2DM pathology, their salivary assessments may receive clinical acceptance.http://dx.doi.org/10.1155/2018/7463796 |
| spellingShingle | Mythily Srinivasan Melinda L. Meadows Lisa Maxwell Assessment of Salivary Adipokines Resistin, Visfatin, and Ghrelin as Type 2 Diabetes Mellitus Biomarkers Biochemistry Research International |
| title | Assessment of Salivary Adipokines Resistin, Visfatin, and Ghrelin as Type 2 Diabetes Mellitus Biomarkers |
| title_full | Assessment of Salivary Adipokines Resistin, Visfatin, and Ghrelin as Type 2 Diabetes Mellitus Biomarkers |
| title_fullStr | Assessment of Salivary Adipokines Resistin, Visfatin, and Ghrelin as Type 2 Diabetes Mellitus Biomarkers |
| title_full_unstemmed | Assessment of Salivary Adipokines Resistin, Visfatin, and Ghrelin as Type 2 Diabetes Mellitus Biomarkers |
| title_short | Assessment of Salivary Adipokines Resistin, Visfatin, and Ghrelin as Type 2 Diabetes Mellitus Biomarkers |
| title_sort | assessment of salivary adipokines resistin visfatin and ghrelin as type 2 diabetes mellitus biomarkers |
| url | http://dx.doi.org/10.1155/2018/7463796 |
| work_keys_str_mv | AT mythilysrinivasan assessmentofsalivaryadipokinesresistinvisfatinandghrelinastype2diabetesmellitusbiomarkers AT melindalmeadows assessmentofsalivaryadipokinesresistinvisfatinandghrelinastype2diabetesmellitusbiomarkers AT lisamaxwell assessmentofsalivaryadipokinesresistinvisfatinandghrelinastype2diabetesmellitusbiomarkers |