Prevalence of pre-diabetes and undiagnosed diabetes in the Mollerussa prospective observational cohort study in a semi-rural area of Catalonia
Objectives To assess the prevalence of undiagnosed diabetes and pre-diabetes in the healthy population in the Mollerussa cohort. As a secondary objective, to identify the variables associated with these conditions and to describe the changes in glycaemic status after 1 year of follow-up in subjects...
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BMJ Publishing Group
2020-01-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/1/e033332.full |
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| author | Josep Ramon Marsal Josep Franch-Nadal Manel Mata-Cases Didac Mauricio Mireia Falguera Maria Belén Vilanova Nuria Alcubierre Minerva Granado-Casas Neus Miró Cristina Cebrian Àngels Molló Esmeralda Castelblanco |
| author_facet | Josep Ramon Marsal Josep Franch-Nadal Manel Mata-Cases Didac Mauricio Mireia Falguera Maria Belén Vilanova Nuria Alcubierre Minerva Granado-Casas Neus Miró Cristina Cebrian Àngels Molló Esmeralda Castelblanco |
| author_sort | Josep Ramon Marsal |
| collection | DOAJ |
| description | Objectives To assess the prevalence of undiagnosed diabetes and pre-diabetes in the healthy population in the Mollerussa cohort. As a secondary objective, to identify the variables associated with these conditions and to describe the changes in glycaemic status after 1 year of follow-up in subjects with pre-diabetes.Design Prospective observational cohort study.Setting General population from a semi-rural area.Participants The study included 583 participants without a diagnosis of diabetes recruited between March 2011 and July 2014.Results The prevalence of undiagnosed diabetes was 20, 3.4% (95% CI 2.6 to 4.2) and that of pre-diabetes was 229, 39.3% (37.3 to 41.3). Among those with pre-diabetes, 18.3% had isolated impaired fasting plasma glucose (FPG) (FPG: 100 to <126 mg/dL), 58.1% had isolated impaired glycated haemoglobin (HbA1c) (HbA1c 5.7 to <6.5) and 23.6% fulfilled both criteria. Follow-up data were available for 166 subjects; 41.6%(37.8 to 45.4) returned to normoglycaemia, 57.6% (57.8 to 61.4) persisted in pre-diabetes and 0.6% (0 to 1.2) progressed to diabetes. Individuals with pre-diabetes had worse cardiometabolic risk profiles and sociodemographic features than normoglycaemic subjects. In the logistic regression model, variables significantly associated with pre-diabetes were older age (OR; 95% CI) (1.033; 1.011 to 1.056), higher physical activity (0.546; 0.360 to 0.827), body mass index (1.121; 1.029 to 1.222) and a family history of diabetes (1.543; 1.025 to 2.323). The variables significantly associated with glycaemic normalisation were older age (0.948; 0.916 to 0.982) and body mass index (0.779; 0.651 to 0.931).Conclusions Among adults in our region, the estimated prevalence of undiagnosed diabetes was 3.4% and that of pre-diabetes was 39.3%. After a 1-year follow-up, a small proportion of subjects (0.6%) with pre-diabetes progressed to diabetes, while a high proportion (41.6%) returned to normoglycaemia. Individuals with pre-diabetes who returned to normoglycaemia were younger and had a lower body mass index. |
| format | Article |
| id | doaj-art-c52bd34c89ec43d4bfbbfa712b8e8243 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-01-01 |
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| spelling | doaj-art-c52bd34c89ec43d4bfbbfa712b8e82432024-12-06T10:00:10ZengBMJ Publishing GroupBMJ Open2044-60552020-01-0110110.1136/bmjopen-2019-033332Prevalence of pre-diabetes and undiagnosed diabetes in the Mollerussa prospective observational cohort study in a semi-rural area of CataloniaJosep Ramon Marsal0Josep Franch-Nadal1Manel Mata-Cases2Didac Mauricio3Mireia Falguera4Maria Belén Vilanova5Nuria Alcubierre6Minerva Granado-Casas7Neus Miró8Cristina Cebrian9Àngels Molló10Esmeralda Castelblanco11RTI Health Solutions Barcelona, Barcelona, Spain2 CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Barcelona, SpainDAP-Cat group, Unitat de Suport a la Recerca Barcelona, Fundació Institut Universitari per a la recerca a l`Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain4 Department of Endocrinology & Nutrition, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain1 Primary Health Care Centre Cervera, Gerència d`Atenció Primaria, Institut Català de la Salut, Lleida, Spain2 Department of Medicine, University of Lleida & Biomedical Research Institute of Lleida, Lleida, Spain4 Department of Nutrition and Dietetics, Avantmedic, Lleida, Spain2 Department of Medicine, University of Lleida & Biomedical Research Institute of Lleida, Lleida, Spain8 Primary Health Care Centre Tàrrega, Gerència d’Atenció Primaria, Institut Català de la Salut, Lleida, Spain9 Primary Health Care Centre Mollerussa, Gerència d`Atenció Primaria, Institut Català de la Salut, Lleida, Spain10 Primary Health Care Centre Guissona, Gerència d`Atenció Primaria, Institut Català de la Salut, Lleida, SpainDAP-Cat group, Unitat de Suport a la Recerca Barcelona, Fundació Institut Universitari per a la recerca a l`Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, SpainObjectives To assess the prevalence of undiagnosed diabetes and pre-diabetes in the healthy population in the Mollerussa cohort. As a secondary objective, to identify the variables associated with these conditions and to describe the changes in glycaemic status after 1 year of follow-up in subjects with pre-diabetes.Design Prospective observational cohort study.Setting General population from a semi-rural area.Participants The study included 583 participants without a diagnosis of diabetes recruited between March 2011 and July 2014.Results The prevalence of undiagnosed diabetes was 20, 3.4% (95% CI 2.6 to 4.2) and that of pre-diabetes was 229, 39.3% (37.3 to 41.3). Among those with pre-diabetes, 18.3% had isolated impaired fasting plasma glucose (FPG) (FPG: 100 to <126 mg/dL), 58.1% had isolated impaired glycated haemoglobin (HbA1c) (HbA1c 5.7 to <6.5) and 23.6% fulfilled both criteria. Follow-up data were available for 166 subjects; 41.6%(37.8 to 45.4) returned to normoglycaemia, 57.6% (57.8 to 61.4) persisted in pre-diabetes and 0.6% (0 to 1.2) progressed to diabetes. Individuals with pre-diabetes had worse cardiometabolic risk profiles and sociodemographic features than normoglycaemic subjects. In the logistic regression model, variables significantly associated with pre-diabetes were older age (OR; 95% CI) (1.033; 1.011 to 1.056), higher physical activity (0.546; 0.360 to 0.827), body mass index (1.121; 1.029 to 1.222) and a family history of diabetes (1.543; 1.025 to 2.323). The variables significantly associated with glycaemic normalisation were older age (0.948; 0.916 to 0.982) and body mass index (0.779; 0.651 to 0.931).Conclusions Among adults in our region, the estimated prevalence of undiagnosed diabetes was 3.4% and that of pre-diabetes was 39.3%. After a 1-year follow-up, a small proportion of subjects (0.6%) with pre-diabetes progressed to diabetes, while a high proportion (41.6%) returned to normoglycaemia. Individuals with pre-diabetes who returned to normoglycaemia were younger and had a lower body mass index.https://bmjopen.bmj.com/content/10/1/e033332.full |
| spellingShingle | Josep Ramon Marsal Josep Franch-Nadal Manel Mata-Cases Didac Mauricio Mireia Falguera Maria Belén Vilanova Nuria Alcubierre Minerva Granado-Casas Neus Miró Cristina Cebrian Àngels Molló Esmeralda Castelblanco Prevalence of pre-diabetes and undiagnosed diabetes in the Mollerussa prospective observational cohort study in a semi-rural area of Catalonia BMJ Open |
| title | Prevalence of pre-diabetes and undiagnosed diabetes in the Mollerussa prospective observational cohort study in a semi-rural area of Catalonia |
| title_full | Prevalence of pre-diabetes and undiagnosed diabetes in the Mollerussa prospective observational cohort study in a semi-rural area of Catalonia |
| title_fullStr | Prevalence of pre-diabetes and undiagnosed diabetes in the Mollerussa prospective observational cohort study in a semi-rural area of Catalonia |
| title_full_unstemmed | Prevalence of pre-diabetes and undiagnosed diabetes in the Mollerussa prospective observational cohort study in a semi-rural area of Catalonia |
| title_short | Prevalence of pre-diabetes and undiagnosed diabetes in the Mollerussa prospective observational cohort study in a semi-rural area of Catalonia |
| title_sort | prevalence of pre diabetes and undiagnosed diabetes in the mollerussa prospective observational cohort study in a semi rural area of catalonia |
| url | https://bmjopen.bmj.com/content/10/1/e033332.full |
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