MicroRNA-19b-3p dysfunction of mesenchymal stem cell-derived exosomes from patients with abdominal aortic aneurysm impairs therapeutic efficacy

MicroRNA-19b-3p dysfunction of mesenchymal stem cell-derived exosomes from patients with abdominal aortic aneurysm impairs therapeutic efficacy

Abstract Senescence of vascular smooth muscle cells (VSMCs) contributes to the formation of abdominal aortic aneurysm (AAA). Although mesenchymal stem cell exosomes (MSC-EXO) have been confirmed to restrict the development of AAA, their biological activity depends largely on the physiological state...

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Bibliographic Details
Main Authors: Yuxiao Zhang, Xiaoran Huang, Tucheng Sun, Linli Shi, Baojuan Liu, Yimei Hong, Qing-Ling Fu, Yuelin Zhang, Xin Li
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Journal of Nanobiotechnology
Subjects:
Mesenchymal stem cells
Exosomes
Abdominal aortic aneurysm
Vascular smooth muscle cells
Senescence
Online Access:https://doi.org/10.1186/s12951-023-01894-3
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