Association between brain morphometry and aerobic fitness level and sex in healthy emerging adults.
<h4>Objective</h4>Aerobic fitness may be beneficial for neuroanatomical structure. However, few have investigated this in emerging adults while also accounting for potential sex differences. Here we examine aerobic fitness level, sex, and their interaction in relation to cortical thickne...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0242738&type=printable |
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| author | Natasha E Wade Alexander L Wallace Ryan M Sullivan Ann M Swartz Krista M Lisdahl |
| author_facet | Natasha E Wade Alexander L Wallace Ryan M Sullivan Ann M Swartz Krista M Lisdahl |
| author_sort | Natasha E Wade |
| collection | DOAJ |
| description | <h4>Objective</h4>Aerobic fitness may be beneficial for neuroanatomical structure. However, few have investigated this in emerging adults while also accounting for potential sex differences. Here we examine aerobic fitness level, sex, and their interaction in relation to cortical thickness, surface area, and volume.<h4>Method</h4>Sixty-three young adults between the ages of 16-26 were balanced for sex and demonstrated a wide range of aerobic fitness levels. Exclusion criteria included left-handedness, past-year independent Axis-I disorders, major medical/neurologic disorders, prenatal medical issues, prenatal alcohol/illicit drug exposure, or excessive substance use. Participants completed an MRI scan and a graded exercise test to volitional fatigue (VO2 max). Data analyses were run in Freesurfer and data was corrected for multiple comparisons with Monte Carlo simulations at .05.<h4>Results</h4>Males demonstrated higher VO2 values. Higher VO2 values were statistically independently related to thinner lateral occipital, superior parietal, cuneus, precuneus, and inferior parietal regions, smaller lateral occipital volume, and larger inferior parietal surface area. Compared to females, males had larger volume in rostral anterior cingulate, lateral occipital, and superior frontal regions, and greater surface area in fusiform, inferior parietal, rostral and caudal anterior cingulate, and superior parietal regions. VO2*Sex interactions revealed higher-fit females had higher inferior parietal, paracentral, and supramarginal surface area, while lower-fit males showed larger surface area in these same regions.<h4>Conclusions</h4>Individuals with higher aerobic fitness performance had thinner cortices, lower volume, and larger surface area in sensorimotor regions than lower fit individuals, perhaps suggesting earlier neuromaturation in higher fit individuals. Larger surface area was associated with higher-fit females and lower-fit males. Thus both sex and aerobic fitness are important in shaping brain health in emerging adults. |
| format | Article |
| id | doaj-art-c529f7449cb34b60b4ad5e0bfa8ee8b5 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-c529f7449cb34b60b4ad5e0bfa8ee8b52025-08-20T02:16:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-011512e024273810.1371/journal.pone.0242738Association between brain morphometry and aerobic fitness level and sex in healthy emerging adults.Natasha E WadeAlexander L WallaceRyan M SullivanAnn M SwartzKrista M Lisdahl<h4>Objective</h4>Aerobic fitness may be beneficial for neuroanatomical structure. However, few have investigated this in emerging adults while also accounting for potential sex differences. Here we examine aerobic fitness level, sex, and their interaction in relation to cortical thickness, surface area, and volume.<h4>Method</h4>Sixty-three young adults between the ages of 16-26 were balanced for sex and demonstrated a wide range of aerobic fitness levels. Exclusion criteria included left-handedness, past-year independent Axis-I disorders, major medical/neurologic disorders, prenatal medical issues, prenatal alcohol/illicit drug exposure, or excessive substance use. Participants completed an MRI scan and a graded exercise test to volitional fatigue (VO2 max). Data analyses were run in Freesurfer and data was corrected for multiple comparisons with Monte Carlo simulations at .05.<h4>Results</h4>Males demonstrated higher VO2 values. Higher VO2 values were statistically independently related to thinner lateral occipital, superior parietal, cuneus, precuneus, and inferior parietal regions, smaller lateral occipital volume, and larger inferior parietal surface area. Compared to females, males had larger volume in rostral anterior cingulate, lateral occipital, and superior frontal regions, and greater surface area in fusiform, inferior parietal, rostral and caudal anterior cingulate, and superior parietal regions. VO2*Sex interactions revealed higher-fit females had higher inferior parietal, paracentral, and supramarginal surface area, while lower-fit males showed larger surface area in these same regions.<h4>Conclusions</h4>Individuals with higher aerobic fitness performance had thinner cortices, lower volume, and larger surface area in sensorimotor regions than lower fit individuals, perhaps suggesting earlier neuromaturation in higher fit individuals. Larger surface area was associated with higher-fit females and lower-fit males. Thus both sex and aerobic fitness are important in shaping brain health in emerging adults.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0242738&type=printable |
| spellingShingle | Natasha E Wade Alexander L Wallace Ryan M Sullivan Ann M Swartz Krista M Lisdahl Association between brain morphometry and aerobic fitness level and sex in healthy emerging adults. PLoS ONE |
| title | Association between brain morphometry and aerobic fitness level and sex in healthy emerging adults. |
| title_full | Association between brain morphometry and aerobic fitness level and sex in healthy emerging adults. |
| title_fullStr | Association between brain morphometry and aerobic fitness level and sex in healthy emerging adults. |
| title_full_unstemmed | Association between brain morphometry and aerobic fitness level and sex in healthy emerging adults. |
| title_short | Association between brain morphometry and aerobic fitness level and sex in healthy emerging adults. |
| title_sort | association between brain morphometry and aerobic fitness level and sex in healthy emerging adults |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0242738&type=printable |
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