Coupling Planar Cell Polarity Signaling to Morphogenesis
Epithelial cells and other groups of cells acquire a polarity orthogonal to their apical–basal axes, referred to as Planar Cell Polarity (PCP). The process by which these cells become polarized requires a signaling pathway using Frizzled as a receptor. Responding cells sense cues from their environm...
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| Format: | Article |
| Language: | English |
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Wiley
2002-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2002.105 |
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| _version_ | 1832558343286161408 |
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| author | Jeffrey D. Axelrod Helen McNeill |
| author_facet | Jeffrey D. Axelrod Helen McNeill |
| author_sort | Jeffrey D. Axelrod |
| collection | DOAJ |
| description | Epithelial cells and other groups of cells acquire a polarity orthogonal to their apical–basal axes, referred to as Planar Cell Polarity (PCP). The process by which these cells become polarized requires a signaling pathway using Frizzled as a receptor. Responding cells sense cues from their environment that provide directional information, and they translate this information into cellular asymmetry. Most of what is known about PCP derives from studies in the fruit fly, Drosophila. We review what is known about how cells translate an unknown signal into asymmetric cytoskeletal reorganization. We then discuss how the vertebrate processes of convergent extension and cochlear hair-cell development may relate to Drosophila PCP signaling. |
| format | Article |
| id | doaj-art-c52916fea93d4efdacb2ab60b46ef937 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-c52916fea93d4efdacb2ab60b46ef9372025-02-03T01:32:44ZengWileyThe Scientific World Journal1537-744X2002-01-01243445410.1100/tsw.2002.105Coupling Planar Cell Polarity Signaling to MorphogenesisJeffrey D. Axelrod0Helen McNeill1Department of Pathology, L235, Stanford University School of Medicine, Stanford, CA 94305-5324, USADevelopmental Patterning Laboratory, ICRF, 44 Lincoln’s Inn Fields, London WC2A 3PX, UKEpithelial cells and other groups of cells acquire a polarity orthogonal to their apical–basal axes, referred to as Planar Cell Polarity (PCP). The process by which these cells become polarized requires a signaling pathway using Frizzled as a receptor. Responding cells sense cues from their environment that provide directional information, and they translate this information into cellular asymmetry. Most of what is known about PCP derives from studies in the fruit fly, Drosophila. We review what is known about how cells translate an unknown signal into asymmetric cytoskeletal reorganization. We then discuss how the vertebrate processes of convergent extension and cochlear hair-cell development may relate to Drosophila PCP signaling.http://dx.doi.org/10.1100/tsw.2002.105 |
| spellingShingle | Jeffrey D. Axelrod Helen McNeill Coupling Planar Cell Polarity Signaling to Morphogenesis The Scientific World Journal |
| title | Coupling Planar Cell Polarity Signaling to Morphogenesis |
| title_full | Coupling Planar Cell Polarity Signaling to Morphogenesis |
| title_fullStr | Coupling Planar Cell Polarity Signaling to Morphogenesis |
| title_full_unstemmed | Coupling Planar Cell Polarity Signaling to Morphogenesis |
| title_short | Coupling Planar Cell Polarity Signaling to Morphogenesis |
| title_sort | coupling planar cell polarity signaling to morphogenesis |
| url | http://dx.doi.org/10.1100/tsw.2002.105 |
| work_keys_str_mv | AT jeffreydaxelrod couplingplanarcellpolaritysignalingtomorphogenesis AT helenmcneill couplingplanarcellpolaritysignalingtomorphogenesis |