Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction

Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction

Abstract The lack of a robust system to reproducibly propagate HRV-C, a family of viruses refractory to cultivation in standard cell lines, has substantially hindered our understanding of this common respiratory pathogen. We sought to develop an organoid-based system to reproducibly propagate HRV-C,...

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Main Authors: Cun Li, Yifei Yu, Zhixin Wan, Man Chun Chiu, Jingjing Huang, Shuxin Zhang, Xiaoxin Zhu, Qiaoshuai Lan, Yanlin Deng, Ying Zhou, Wei Xue, Ming Yue, Jian-Piao Cai, Cyril Chik-Yan Yip, Kenneth Kak-Yuen Wong, Xiaojuan Liu, Yang Yu, Lin Huang, Hin Chu, Jasper Fuk-Woo Chan, Hans Clevers, Kwok Yung Yuen, Jie Zhou
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55076-2
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