METTL16-dependent GPX4 m6A modification links ferroptosis to NSCLC TKIs resistance

METTL16-dependent GPX4 m6A modification links ferroptosis to NSCLC TKIs resistance

Abstract Background Non-small-cell lung cancer (NSCLC) is a highly aggressive cancer with a poor prognosis, largely due to increasing resistance to Tyrosine Kinase Inhibitors (TKIs). The mechanisms of NSCLC TKI resistance remain unknown. This study aimed to elucidate the molecular mechanism of METTL...

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Bibliographic Details
Main Authors: Yingou Zeng, Qiang Wang, Di Qiao, Bin Dai, Yunlong Wu, Meng Wang, Zhe Fan, Jia Chen
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Cancer
Subjects:
NSCLC
Proliferation
GPX4
Ferroptosis
AZD-9291 resistance
Online Access:https://doi.org/10.1186/s12885-025-14729-1
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