Advantages of using biofilms to obtain high-value molecules by microbial biotransformations
Microbial biotransformations are valuable tools from “green chemistry” and involve converting parental molecules into new daughter ones with unique physical, chemical, or pharmacological properties. These reactions are often carried out by cells grown under a planktonic phenotype. However, microbial...
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| Format: | Article |
| Language: | English |
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Open Exploration
2025-01-01
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| Series: | Exploration of Drug Science |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A100884/100884.pdf |
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| author | Nicoly Subtil de Oliveira Romeu Cassiano Pucci da Silva Ramos Rafaela Caldas de Paula Matheus Gonçalves da Costa Pereira Rosimeire Takaki Rosa Luiz Fernando Bianchini Edvaldo Antonio Ribeiro Rosa |
| author_facet | Nicoly Subtil de Oliveira Romeu Cassiano Pucci da Silva Ramos Rafaela Caldas de Paula Matheus Gonçalves da Costa Pereira Rosimeire Takaki Rosa Luiz Fernando Bianchini Edvaldo Antonio Ribeiro Rosa |
| author_sort | Nicoly Subtil de Oliveira |
| collection | DOAJ |
| description | Microbial biotransformations are valuable tools from “green chemistry” and involve converting parental molecules into new daughter ones with unique physical, chemical, or pharmacological properties. These reactions are often carried out by cells grown under a planktonic phenotype. However, microbial cells grown under a phenotype of biofilm can improve biotransformation bioprocesses once they form more biomass per volume, are more resistant to extreme conditions (pH, temperature, and toxic substances), remain active for extended periods, are less prone to cell washouts, and reduce re-inoculation demands, leading to increased production rates due to their unique physiological features. In addition, experience has shown that biofilms may furnish a broader array of new daughter molecules. This review highlighted the benefits of using biofilms in microbial biotransformations to obtain a variety of bioactives. |
| format | Article |
| id | doaj-art-c51e0dfc53404d92949a489954327156 |
| institution | Kabale University |
| issn | 2836-7677 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Open Exploration |
| record_format | Article |
| series | Exploration of Drug Science |
| spelling | doaj-art-c51e0dfc53404d92949a4899543271562025-02-08T03:05:27ZengOpen ExplorationExploration of Drug Science2836-76772025-01-01310088410.37349/eds.2025.100884Advantages of using biofilms to obtain high-value molecules by microbial biotransformationsNicoly Subtil de Oliveira0https://orcid.org/0000-0002-5570-8036Romeu Cassiano Pucci da Silva Ramos1https://orcid.org/0000-0001-8067-6630Rafaela Caldas de Paula2https://orcid.org/0000-0001-6631-8618Matheus Gonçalves da Costa Pereira3https://orcid.org/0009-0009-2182-7684Rosimeire Takaki Rosa4https://orcid.org/0000-0002-8352-9078Luiz Fernando Bianchini5https://orcid.org/0000-0003-4634-6624Edvaldo Antonio Ribeiro Rosa6https://orcid.org/0000-0001-6087-4365Xenobiotics Research Unit, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, Brazil; Graduate Program in Animal Science, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, BrazilXenobiotics Research Unit, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, Brazil; Graduate Program in Dentistry, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, BrazilXenobiotics Research Unit, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, Brazil; Graduate Program in Dentistry, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, BrazilXenobiotics Research Unit, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, BrazilXenobiotics Research Unit, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, BrazilXenobiotics Research Unit, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, BrazilXenobiotics Research Unit, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, Brazil; Graduate Program in Animal Science, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, Brazil; Graduate Program in Dentistry, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, BrazilMicrobial biotransformations are valuable tools from “green chemistry” and involve converting parental molecules into new daughter ones with unique physical, chemical, or pharmacological properties. These reactions are often carried out by cells grown under a planktonic phenotype. However, microbial cells grown under a phenotype of biofilm can improve biotransformation bioprocesses once they form more biomass per volume, are more resistant to extreme conditions (pH, temperature, and toxic substances), remain active for extended periods, are less prone to cell washouts, and reduce re-inoculation demands, leading to increased production rates due to their unique physiological features. In addition, experience has shown that biofilms may furnish a broader array of new daughter molecules. This review highlighted the benefits of using biofilms in microbial biotransformations to obtain a variety of bioactives.https://www.explorationpub.com/uploads/Article/A100884/100884.pdfmicrobial biotransformationbiofilmspharmaceuticalsfine chemicals |
| spellingShingle | Nicoly Subtil de Oliveira Romeu Cassiano Pucci da Silva Ramos Rafaela Caldas de Paula Matheus Gonçalves da Costa Pereira Rosimeire Takaki Rosa Luiz Fernando Bianchini Edvaldo Antonio Ribeiro Rosa Advantages of using biofilms to obtain high-value molecules by microbial biotransformations Exploration of Drug Science microbial biotransformation biofilms pharmaceuticals fine chemicals |
| title | Advantages of using biofilms to obtain high-value molecules by microbial biotransformations |
| title_full | Advantages of using biofilms to obtain high-value molecules by microbial biotransformations |
| title_fullStr | Advantages of using biofilms to obtain high-value molecules by microbial biotransformations |
| title_full_unstemmed | Advantages of using biofilms to obtain high-value molecules by microbial biotransformations |
| title_short | Advantages of using biofilms to obtain high-value molecules by microbial biotransformations |
| title_sort | advantages of using biofilms to obtain high value molecules by microbial biotransformations |
| topic | microbial biotransformation biofilms pharmaceuticals fine chemicals |
| url | https://www.explorationpub.com/uploads/Article/A100884/100884.pdf |
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