Nanohybrid cerasomes: Advancements in targeted drug and gene delivery
Nanohybrid cerasomes represent a significant advancement in the field of drug delivery systems, offering a superior alternative to traditional cerasomes and liposomes. Cerasomes are biocompatible colloidal nanoparticles characterized by an additional polyorganosiloxane network layer that enhances th...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | European Journal of Medicinal Chemistry Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772417424000505 |
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| author | Kalyani Pathak Mohammad Zaki Ahmad Riya Saikia Partha Protim Borthakur Pallab Pramanik Md Ariful Islam Aparoop Das Basel A. Abdel-Wahab Dibyajyoti Das Saptasikha Gogoi |
| author_facet | Kalyani Pathak Mohammad Zaki Ahmad Riya Saikia Partha Protim Borthakur Pallab Pramanik Md Ariful Islam Aparoop Das Basel A. Abdel-Wahab Dibyajyoti Das Saptasikha Gogoi |
| author_sort | Kalyani Pathak |
| collection | DOAJ |
| description | Nanohybrid cerasomes represent a significant advancement in the field of drug delivery systems, offering a superior alternative to traditional cerasomes and liposomes. Cerasomes are biocompatible colloidal nanoparticles characterized by an additional polyorganosiloxane network layer that enhances their stability compared to conventional liposomes. The novel hybrid liposomal cerasome, featuring a partial ceramic or silica coating, has garnered substantial interest due to its unique structure. This structure provides better morphological stability than traditional liposomes and, in comparison to silica nanoparticles, significantly reduces overall stiffness and density. By incorporating liposomal architecture, cerasomes achieve greater biocompatibility than silica nanoparticles. This unique combination leverages the benefits of both liposomes and silica nanoparticles while mitigating their respective drawbacks, positioning cerasomes as an optimal drug delivery system. Nanohybrid cerasomes offer extended circulation residence time, enabling more efficient drug delivery to disease sites and facilitating the targeting of specific disease cells. Their potential as intracellular delivery vehicles for proteins, peptides, antisense compounds, ribozymes, and DNA is particularly noteworthy. The presence of a liposomal bilayer structure in cerasomes reduces rigidity and density, enhancing their stability and effectiveness as drug and gene delivery vehicles. This article reviews the techniques for preparing cerasomes and explores their applications in targeted drug and gene delivery systems, highlighting their advantages over conventional liposomes and silica nanoparticles. |
| format | Article |
| id | doaj-art-c51cfa920fa8494391f5a8871bc96fcd |
| institution | OA Journals |
| issn | 2772-4174 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Medicinal Chemistry Reports |
| spelling | doaj-art-c51cfa920fa8494391f5a8871bc96fcd2025-08-20T02:35:56ZengElsevierEuropean Journal of Medicinal Chemistry Reports2772-41742024-12-011210017810.1016/j.ejmcr.2024.100178Nanohybrid cerasomes: Advancements in targeted drug and gene deliveryKalyani Pathak0Mohammad Zaki Ahmad1Riya Saikia2Partha Protim Borthakur3Pallab Pramanik4Md Ariful Islam5Aparoop Das6Basel A. Abdel-Wahab7Dibyajyoti Das8Saptasikha Gogoi9Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, 786004, Assam, India; Corresponding author.Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, 11001, Saudi ArabiaDepartment of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, 786004, Assam, IndiaDepartment of Mechanical Engineering, Dibrugarh University, Dibrugarh, 786004, Assam, IndiaDepartment of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, 786004, Assam, IndiaDepartment of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, 786004, Assam, IndiaDepartment of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, 786004, Assam, IndiaDepartment of Pharmacology, College of Pharmacy, Najran University, P.O. Box 1988, Najran, 71111, Saudi ArabiaDepartment of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, 786004, Assam, India; Pratiksha Institute of Pharmaceutical Science, Panikhaiti, Guwahati, Assam, 781026, IndiaCentre for Biotechnology and Bioinformatics, Dibrugarh University, Dibrugarh, 786004, Assam, IndiaNanohybrid cerasomes represent a significant advancement in the field of drug delivery systems, offering a superior alternative to traditional cerasomes and liposomes. Cerasomes are biocompatible colloidal nanoparticles characterized by an additional polyorganosiloxane network layer that enhances their stability compared to conventional liposomes. The novel hybrid liposomal cerasome, featuring a partial ceramic or silica coating, has garnered substantial interest due to its unique structure. This structure provides better morphological stability than traditional liposomes and, in comparison to silica nanoparticles, significantly reduces overall stiffness and density. By incorporating liposomal architecture, cerasomes achieve greater biocompatibility than silica nanoparticles. This unique combination leverages the benefits of both liposomes and silica nanoparticles while mitigating their respective drawbacks, positioning cerasomes as an optimal drug delivery system. Nanohybrid cerasomes offer extended circulation residence time, enabling more efficient drug delivery to disease sites and facilitating the targeting of specific disease cells. Their potential as intracellular delivery vehicles for proteins, peptides, antisense compounds, ribozymes, and DNA is particularly noteworthy. The presence of a liposomal bilayer structure in cerasomes reduces rigidity and density, enhancing their stability and effectiveness as drug and gene delivery vehicles. This article reviews the techniques for preparing cerasomes and explores their applications in targeted drug and gene delivery systems, highlighting their advantages over conventional liposomes and silica nanoparticles.http://www.sciencedirect.com/science/article/pii/S2772417424000505CerasomesLiposomesDrug deliverySilica nanoparticlesGene delivery |
| spellingShingle | Kalyani Pathak Mohammad Zaki Ahmad Riya Saikia Partha Protim Borthakur Pallab Pramanik Md Ariful Islam Aparoop Das Basel A. Abdel-Wahab Dibyajyoti Das Saptasikha Gogoi Nanohybrid cerasomes: Advancements in targeted drug and gene delivery European Journal of Medicinal Chemistry Reports Cerasomes Liposomes Drug delivery Silica nanoparticles Gene delivery |
| title | Nanohybrid cerasomes: Advancements in targeted drug and gene delivery |
| title_full | Nanohybrid cerasomes: Advancements in targeted drug and gene delivery |
| title_fullStr | Nanohybrid cerasomes: Advancements in targeted drug and gene delivery |
| title_full_unstemmed | Nanohybrid cerasomes: Advancements in targeted drug and gene delivery |
| title_short | Nanohybrid cerasomes: Advancements in targeted drug and gene delivery |
| title_sort | nanohybrid cerasomes advancements in targeted drug and gene delivery |
| topic | Cerasomes Liposomes Drug delivery Silica nanoparticles Gene delivery |
| url | http://www.sciencedirect.com/science/article/pii/S2772417424000505 |
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