Budd-chiari syndrome associated with acute promyelocytic leukemia: a case and literature review
Background Acute promyelocytic leukemia (APL) is prone to hemorrhage and thrombosis during onset and induction treatment. Occasionally, severe and rare thrombosis can occur, which deserves our attention. Such as Budd-Chiari syndrome (BCS). BCS is a rare and severe disease caused by occlusion of the...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Hematology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16078454.2025.2536390 |
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| author | Honglei Wang Jing Guan Jia Zeng Ting Wang Xu Lang Rong Fu |
| author_facet | Honglei Wang Jing Guan Jia Zeng Ting Wang Xu Lang Rong Fu |
| author_sort | Honglei Wang |
| collection | DOAJ |
| description | Background Acute promyelocytic leukemia (APL) is prone to hemorrhage and thrombosis during onset and induction treatment. Occasionally, severe and rare thrombosis can occur, which deserves our attention. Such as Budd-Chiari syndrome (BCS). BCS is a rare and severe disease caused by occlusion of the hepatic veins. Ascites, abdominal pain, and abnormal liver function are the first manifestations of this disease.Case presentation We report the case of a high-risk patient with APL with acute liver failure and massive ascites during induction therapy due to BCS. He was in a critical condition between life-threatening bleeding tendency and thrombosis. The patient was successfully treated with thrombectomy of the right hepatic vein and balloon dilatation therapy, which provided time for APL treatment.Conclusion Our case highlights an uncommon venous thrombosis due to APL. We hope to provide some new treatment options for clinicians. |
| format | Article |
| id | doaj-art-c519eb414e3a4f94aa02e295feb28bfd |
| institution | Kabale University |
| issn | 1607-8454 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hematology |
| spelling | doaj-art-c519eb414e3a4f94aa02e295feb28bfd2025-08-20T03:32:54ZengTaylor & Francis GroupHematology1607-84542025-12-0130110.1080/16078454.2025.2536390Budd-chiari syndrome associated with acute promyelocytic leukemia: a case and literature reviewHonglei Wang0Jing Guan1Jia Zeng2Ting Wang3Xu Lang4Rong Fu5Department of Hematology, Tianjin Medical University General Hospital, Tianjin, People's Republic of ChinaDepartment of Hematology, Tianjin Medical University General Hospital, Tianjin, People's Republic of ChinaDepartment of Radiology, Tianjin Medical University General Hospital, Tianjin, People's Republic of ChinaDepartment of Hematology, Tianjin Medical University General Hospital, Tianjin, People's Republic of ChinaDepartment of Radiology, Tianjin Medical University General Hospital, Tianjin, People's Republic of ChinaDepartment of Hematology, Tianjin Medical University General Hospital, Tianjin, People's Republic of ChinaBackground Acute promyelocytic leukemia (APL) is prone to hemorrhage and thrombosis during onset and induction treatment. Occasionally, severe and rare thrombosis can occur, which deserves our attention. Such as Budd-Chiari syndrome (BCS). BCS is a rare and severe disease caused by occlusion of the hepatic veins. Ascites, abdominal pain, and abnormal liver function are the first manifestations of this disease.Case presentation We report the case of a high-risk patient with APL with acute liver failure and massive ascites during induction therapy due to BCS. He was in a critical condition between life-threatening bleeding tendency and thrombosis. The patient was successfully treated with thrombectomy of the right hepatic vein and balloon dilatation therapy, which provided time for APL treatment.Conclusion Our case highlights an uncommon venous thrombosis due to APL. We hope to provide some new treatment options for clinicians.https://www.tandfonline.com/doi/10.1080/16078454.2025.2536390Acute promyelocytic leukemiahemorrhagethrombosisBudd-Chiari syndromethrombectomy |
| spellingShingle | Honglei Wang Jing Guan Jia Zeng Ting Wang Xu Lang Rong Fu Budd-chiari syndrome associated with acute promyelocytic leukemia: a case and literature review Hematology Acute promyelocytic leukemia hemorrhage thrombosis Budd-Chiari syndrome thrombectomy |
| title | Budd-chiari syndrome associated with acute promyelocytic leukemia: a case and literature review |
| title_full | Budd-chiari syndrome associated with acute promyelocytic leukemia: a case and literature review |
| title_fullStr | Budd-chiari syndrome associated with acute promyelocytic leukemia: a case and literature review |
| title_full_unstemmed | Budd-chiari syndrome associated with acute promyelocytic leukemia: a case and literature review |
| title_short | Budd-chiari syndrome associated with acute promyelocytic leukemia: a case and literature review |
| title_sort | budd chiari syndrome associated with acute promyelocytic leukemia a case and literature review |
| topic | Acute promyelocytic leukemia hemorrhage thrombosis Budd-Chiari syndrome thrombectomy |
| url | https://www.tandfonline.com/doi/10.1080/16078454.2025.2536390 |
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