Octenidine effectively reduces Candida auris colonisation on human skin
Abstract Candidozyma (formerly Candida) auris (C. auris), a WHO critical priority pathogen known for its multi-drug resistance and strong skin tropism, is posing a significant health threat. This study evaluates the efficacy of commercial octenidine-based antiseptics in reducing C. auris colonisatio...
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| Format: | Article |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-11914-x |
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| author | Diana Cerbu Saskia Seiser Trinh Phan-Canh Doris Moser Christian Freystätter Johannes Matiasek Karl Kuchler Adelheid Elbe-Bürger |
| author_facet | Diana Cerbu Saskia Seiser Trinh Phan-Canh Doris Moser Christian Freystätter Johannes Matiasek Karl Kuchler Adelheid Elbe-Bürger |
| author_sort | Diana Cerbu |
| collection | DOAJ |
| description | Abstract Candidozyma (formerly Candida) auris (C. auris), a WHO critical priority pathogen known for its multi-drug resistance and strong skin tropism, is posing a significant health threat. This study evaluates the efficacy of commercial octenidine-based antiseptics in reducing C. auris colonisation on intact and wounded human skin. Using an established ex vivo human skin model to simulate clinical settings, skin samples from healthy donors were exposed to planktonic C. auris cells. Six hours post-contamination, two ready-to-use octenidine-based antiseptics were applied, and fungal colonisation was assessed after 18 h via periodic acid-Schiff staining, bright field and scanning electron microscopy and colony forming unit quantification. In vitro biofilm assays with various C. auris strains, including drug resistant ones, were performed to determine the antifungal effects of octenidine formulations. Results showed that octenidine-based antiseptics significantly reduced C. auris viability on intact and wounded human skin, and also demonstrated a nearly complete eradication across tested strains in vitro. These findings highlight the potential of octenidine-based products in reducing C. auris colonisation, supporting infection prevention and control strategies in healthcare settings and enhancing patient safety. |
| format | Article |
| id | doaj-art-c516d2f271804c56a01072df7642874e |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-c516d2f271804c56a01072df7642874e2025-08-20T04:03:03ZengNature PortfolioScientific Reports2045-23222025-07-0115111110.1038/s41598-025-11914-xOctenidine effectively reduces Candida auris colonisation on human skinDiana Cerbu0Saskia Seiser1Trinh Phan-Canh2Doris Moser3Christian Freystätter4Johannes Matiasek5Karl Kuchler6Adelheid Elbe-Bürger7Department of Dermatology, Medical University of ViennaDepartment of Dermatology, Medical University of ViennaMax Perutz Labs Vienna, Medical University of ViennaDepartment of Cranio-Maxillofacial and Oral Surgery, Medical University of ViennaDepartment of Plastic and Reconstructive Surgery, Medical University of ViennaPlastic, Reconstructive and Aesthetic SurgeryMax Perutz Labs Vienna, Medical University of ViennaDepartment of Dermatology, Medical University of ViennaAbstract Candidozyma (formerly Candida) auris (C. auris), a WHO critical priority pathogen known for its multi-drug resistance and strong skin tropism, is posing a significant health threat. This study evaluates the efficacy of commercial octenidine-based antiseptics in reducing C. auris colonisation on intact and wounded human skin. Using an established ex vivo human skin model to simulate clinical settings, skin samples from healthy donors were exposed to planktonic C. auris cells. Six hours post-contamination, two ready-to-use octenidine-based antiseptics were applied, and fungal colonisation was assessed after 18 h via periodic acid-Schiff staining, bright field and scanning electron microscopy and colony forming unit quantification. In vitro biofilm assays with various C. auris strains, including drug resistant ones, were performed to determine the antifungal effects of octenidine formulations. Results showed that octenidine-based antiseptics significantly reduced C. auris viability on intact and wounded human skin, and also demonstrated a nearly complete eradication across tested strains in vitro. These findings highlight the potential of octenidine-based products in reducing C. auris colonisation, supporting infection prevention and control strategies in healthcare settings and enhancing patient safety.https://doi.org/10.1038/s41598-025-11914-xAntisepticsHuman skinEx vivo modelCandidozyma auris (formerly Candida auris)Antifungal stewardship |
| spellingShingle | Diana Cerbu Saskia Seiser Trinh Phan-Canh Doris Moser Christian Freystätter Johannes Matiasek Karl Kuchler Adelheid Elbe-Bürger Octenidine effectively reduces Candida auris colonisation on human skin Scientific Reports Antiseptics Human skin Ex vivo model Candidozyma auris (formerly Candida auris) Antifungal stewardship |
| title | Octenidine effectively reduces Candida auris colonisation on human skin |
| title_full | Octenidine effectively reduces Candida auris colonisation on human skin |
| title_fullStr | Octenidine effectively reduces Candida auris colonisation on human skin |
| title_full_unstemmed | Octenidine effectively reduces Candida auris colonisation on human skin |
| title_short | Octenidine effectively reduces Candida auris colonisation on human skin |
| title_sort | octenidine effectively reduces candida auris colonisation on human skin |
| topic | Antiseptics Human skin Ex vivo model Candidozyma auris (formerly Candida auris) Antifungal stewardship |
| url | https://doi.org/10.1038/s41598-025-11914-x |
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