Targeting of interleukin-10 receptor by a potential human interleukin-10 peptide efficiently blocks interleukin-10 pathway-dependent cell proliferation

Targeting of interleukin-10 receptor by a potential human interleukin-10 peptide efficiently blocks interleukin-10 pathway-dependent cell proliferation

Objective: Human interleukin-10 (IL-10) is a dimeric and pleiotropic cytokine that plays a crucial role in cellular immunoregulatory responses. As IL-10 binds to its receptors, IL-10Ra and IL-10Rb, it will suppress or induce the downstream cellular immune responses to protect from diseases. Material...

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Bibliographic Details
Main Authors: Chun-Chun Chang, Cheng-Der Liu, Sheng-Feng Pan, Wei-Han Huang, Chih-Wen Peng, Hao-Jen Hsu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Tzu Chi Medical Journal
Subjects:
cytokine
interleukin-10
molecular docking
peptide design
Online Access:http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2020;volume=32;issue=3;spage=245;epage=253;aulast=Chang
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