Antidiabetic Potential of Black Elderberry Cultivars Flower Extracts: Phytochemical Profile and Enzyme Inhibition
Black elderberry (<i>Sambucus nigra</i> L.) flowers are rich in polyphenolic compounds, including chlorogenic acid and quercetin derivatives, which are known for their health benefits, particularly their antioxidant and antidiabetic properties. This study aimed to optimize the extraction...
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MDPI AG
2024-12-01
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| author | Elżbieta Studzińska-Sroka Magdalena Paczkowska-Walendowska Justyna Kledzik Agnieszka Galanty Anna Gościniak Piotr Szulc Katarzyna Korybalska Judyta Cielecka-Piontek |
| author_facet | Elżbieta Studzińska-Sroka Magdalena Paczkowska-Walendowska Justyna Kledzik Agnieszka Galanty Anna Gościniak Piotr Szulc Katarzyna Korybalska Judyta Cielecka-Piontek |
| author_sort | Elżbieta Studzińska-Sroka |
| collection | DOAJ |
| description | Black elderberry (<i>Sambucus nigra</i> L.) flowers are rich in polyphenolic compounds, including chlorogenic acid and quercetin derivatives, which are known for their health benefits, particularly their antioxidant and antidiabetic properties. This study aimed to optimize the extraction conditions using the Box–Behnken model to maximize polyphenol yields from different elderberry flower cultivars and to evaluate their potential for antidiabetic action. The extracts were analyzed for their phytochemical content and assessed for enzyme inhibition, specifically targeting enzymes critical in carbohydrate digestion and glucose regulation. The anti-inflammatory activity was also assessed. Results indicated that the Black Beauty, Obelisk, and Haschberg cultivars demonstrated significant inhibition of α-glucosidase, with a high inhibitory potential against α-amylase enzymes for the Obelisk cultivar. Additionally, high chlorogenic acid content was strongly correlated with enzyme inhibition and antioxidant activity, suggesting its substantial role in glucose regulation. This study underscores the potential of elderberry flower extracts, particularly those rich in chlorogenic acid, as natural agents for managing blood glucose levels, warranting further exploration of their use in antidiabetic applications. |
| format | Article |
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| institution | OA Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-c50cc3d4702143fcb2791e1d3e51e0eb2025-08-20T01:55:31ZengMDPI AGMolecules1420-30492024-12-012923577510.3390/molecules29235775Antidiabetic Potential of Black Elderberry Cultivars Flower Extracts: Phytochemical Profile and Enzyme InhibitionElżbieta Studzińska-Sroka0Magdalena Paczkowska-Walendowska1Justyna Kledzik2Agnieszka Galanty3Anna Gościniak4Piotr Szulc5Katarzyna Korybalska6Judyta Cielecka-Piontek7Department of Pharmacognosy and Biomaterials, Poznań University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandDepartment of Pharmacognosy and Biomaterials, Poznań University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandDepartment of Pharmacognosy and Biomaterials, Poznań University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandDepartment of Pharmacognosy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, PolandDepartment of Pharmacognosy and Biomaterials, Poznań University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandDepartment of Agronomy, Poznań University of Life Sciences, Dojazd 11, 60-632 Poznan, PolandDepartment of Pathophysiology, Poznań University of Medical Sciences, Rokietnicka 8, 60-806 Poznan, PolandDepartment of Pharmacognosy and Biomaterials, Poznań University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, PolandBlack elderberry (<i>Sambucus nigra</i> L.) flowers are rich in polyphenolic compounds, including chlorogenic acid and quercetin derivatives, which are known for their health benefits, particularly their antioxidant and antidiabetic properties. This study aimed to optimize the extraction conditions using the Box–Behnken model to maximize polyphenol yields from different elderberry flower cultivars and to evaluate their potential for antidiabetic action. The extracts were analyzed for their phytochemical content and assessed for enzyme inhibition, specifically targeting enzymes critical in carbohydrate digestion and glucose regulation. The anti-inflammatory activity was also assessed. Results indicated that the Black Beauty, Obelisk, and Haschberg cultivars demonstrated significant inhibition of α-glucosidase, with a high inhibitory potential against α-amylase enzymes for the Obelisk cultivar. Additionally, high chlorogenic acid content was strongly correlated with enzyme inhibition and antioxidant activity, suggesting its substantial role in glucose regulation. This study underscores the potential of elderberry flower extracts, particularly those rich in chlorogenic acid, as natural agents for managing blood glucose levels, warranting further exploration of their use in antidiabetic applications.https://www.mdpi.com/1420-3049/29/23/5775black elderberry<i>Sambucus nigra</i>wild elderberrypolyphenolschlorogenic acidantioxidant activity |
| spellingShingle | Elżbieta Studzińska-Sroka Magdalena Paczkowska-Walendowska Justyna Kledzik Agnieszka Galanty Anna Gościniak Piotr Szulc Katarzyna Korybalska Judyta Cielecka-Piontek Antidiabetic Potential of Black Elderberry Cultivars Flower Extracts: Phytochemical Profile and Enzyme Inhibition Molecules black elderberry <i>Sambucus nigra</i> wild elderberry polyphenols chlorogenic acid antioxidant activity |
| title | Antidiabetic Potential of Black Elderberry Cultivars Flower Extracts: Phytochemical Profile and Enzyme Inhibition |
| title_full | Antidiabetic Potential of Black Elderberry Cultivars Flower Extracts: Phytochemical Profile and Enzyme Inhibition |
| title_fullStr | Antidiabetic Potential of Black Elderberry Cultivars Flower Extracts: Phytochemical Profile and Enzyme Inhibition |
| title_full_unstemmed | Antidiabetic Potential of Black Elderberry Cultivars Flower Extracts: Phytochemical Profile and Enzyme Inhibition |
| title_short | Antidiabetic Potential of Black Elderberry Cultivars Flower Extracts: Phytochemical Profile and Enzyme Inhibition |
| title_sort | antidiabetic potential of black elderberry cultivars flower extracts phytochemical profile and enzyme inhibition |
| topic | black elderberry <i>Sambucus nigra</i> wild elderberry polyphenols chlorogenic acid antioxidant activity |
| url | https://www.mdpi.com/1420-3049/29/23/5775 |
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