Comparative analysis of clinicopathological characteristics in young and elderly patients with oral squamous cell carcinoma: a retrospective study in Northeastern Brazil
Abstract The aim of this study was to perform a clinicopathological analysis of oral squamous cell carcinoma (OSCC) in young patients from the northeast of Brazil and compare with elderly individuals. This retrospective study reviewed 104 OSCC cases from 2000 to 2015, focusing on patients under 40 a...
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Sociedade Brasileira de Pesquisa Odontológica
2024-12-01
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| Series: | Brazilian Oral Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242024000102106&lng=en&tlng=en |
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| author | Pedro Augusto Bulhões CURIOSO Ivan José CORREIA NETO Lucas Lacerda de SOUZA Edilmar de Moura SANTOS Alan Roger SANTOS-SILVA Pablo Agustin VARGAS Marcio Ajudarte LOPES |
| author_facet | Pedro Augusto Bulhões CURIOSO Ivan José CORREIA NETO Lucas Lacerda de SOUZA Edilmar de Moura SANTOS Alan Roger SANTOS-SILVA Pablo Agustin VARGAS Marcio Ajudarte LOPES |
| author_sort | Pedro Augusto Bulhões CURIOSO |
| collection | DOAJ |
| description | Abstract The aim of this study was to perform a clinicopathological analysis of oral squamous cell carcinoma (OSCC) in young patients from the northeast of Brazil and compare with elderly individuals. This retrospective study reviewed 104 OSCC cases from 2000 to 2015, focusing on patients under 40 and over 60 at diagnosis. Forty-two patients under 40 years old (40.38%) and 62 patients over 60 years old (59.62%) were analyzed using descriptive statistics, chi-square, and Fisher’s exact tests for clinicopathological factors, and Kaplan-Meier and Cox models for survival and prognostics. Most of the patients were male, with younger patients having lower rates of smoking (45.24%) and alcohol use (28.57%) compared to older patients (82.30% and 40.32%, respectively). Younger patients had a higher prevalence of tongue cancer and smaller tumors but faced more compromised surgical margins, perineural invasion, local recurrence, regional metastasis, distant metastasis, and second primary tumors. Statistical findings highlighted age-related differences in clinicopathological features and indicated that despite similar overall survival rates, younger patients had a poorer prognosis related to local recurrences, regional recurrences, and second tumors. Perineural invasion emerged as an independent prognostic factor. The study suggests that younger OSCC patients require personalized management strategies to address their higher risk of adverse outcomes, with an emphasis on the prognostic significance of perineural invasion. |
| format | Article |
| id | doaj-art-c5044174cbee48a8ba1c68ea1913bfe7 |
| institution | OA Journals |
| issn | 1807-3107 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Sociedade Brasileira de Pesquisa Odontológica |
| record_format | Article |
| series | Brazilian Oral Research |
| spelling | doaj-art-c5044174cbee48a8ba1c68ea1913bfe72025-08-20T02:36:53ZengSociedade Brasileira de Pesquisa OdontológicaBrazilian Oral Research1807-31072024-12-013810.1590/1807-3107bor-2024.vol38.0138Comparative analysis of clinicopathological characteristics in young and elderly patients with oral squamous cell carcinoma: a retrospective study in Northeastern BrazilPedro Augusto Bulhões CURIOSOhttps://orcid.org/0000-0002-1066-6047Ivan José CORREIA NETOhttps://orcid.org/0009-0007-3828-0107Lucas Lacerda de SOUZAhttps://orcid.org/0000-0002-9481-7796Edilmar de Moura SANTOShttps://orcid.org/0000-0001-5814-8997Alan Roger SANTOS-SILVAhttps://orcid.org/0000-0003-2040-6617Pablo Agustin VARGAShttps://orcid.org/0000-0003-1840-4911Marcio Ajudarte LOPEShttps://orcid.org/0000-0001-6677-0065Abstract The aim of this study was to perform a clinicopathological analysis of oral squamous cell carcinoma (OSCC) in young patients from the northeast of Brazil and compare with elderly individuals. This retrospective study reviewed 104 OSCC cases from 2000 to 2015, focusing on patients under 40 and over 60 at diagnosis. Forty-two patients under 40 years old (40.38%) and 62 patients over 60 years old (59.62%) were analyzed using descriptive statistics, chi-square, and Fisher’s exact tests for clinicopathological factors, and Kaplan-Meier and Cox models for survival and prognostics. Most of the patients were male, with younger patients having lower rates of smoking (45.24%) and alcohol use (28.57%) compared to older patients (82.30% and 40.32%, respectively). Younger patients had a higher prevalence of tongue cancer and smaller tumors but faced more compromised surgical margins, perineural invasion, local recurrence, regional metastasis, distant metastasis, and second primary tumors. Statistical findings highlighted age-related differences in clinicopathological features and indicated that despite similar overall survival rates, younger patients had a poorer prognosis related to local recurrences, regional recurrences, and second tumors. Perineural invasion emerged as an independent prognostic factor. The study suggests that younger OSCC patients require personalized management strategies to address their higher risk of adverse outcomes, with an emphasis on the prognostic significance of perineural invasion.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242024000102106&lng=en&tlng=enSquamous Cell Carcinoma of Head and NeckSurvivalPrognosis |
| spellingShingle | Pedro Augusto Bulhões CURIOSO Ivan José CORREIA NETO Lucas Lacerda de SOUZA Edilmar de Moura SANTOS Alan Roger SANTOS-SILVA Pablo Agustin VARGAS Marcio Ajudarte LOPES Comparative analysis of clinicopathological characteristics in young and elderly patients with oral squamous cell carcinoma: a retrospective study in Northeastern Brazil Brazilian Oral Research Squamous Cell Carcinoma of Head and Neck Survival Prognosis |
| title | Comparative analysis of clinicopathological characteristics in young and elderly patients with oral squamous cell carcinoma: a retrospective study in Northeastern Brazil |
| title_full | Comparative analysis of clinicopathological characteristics in young and elderly patients with oral squamous cell carcinoma: a retrospective study in Northeastern Brazil |
| title_fullStr | Comparative analysis of clinicopathological characteristics in young and elderly patients with oral squamous cell carcinoma: a retrospective study in Northeastern Brazil |
| title_full_unstemmed | Comparative analysis of clinicopathological characteristics in young and elderly patients with oral squamous cell carcinoma: a retrospective study in Northeastern Brazil |
| title_short | Comparative analysis of clinicopathological characteristics in young and elderly patients with oral squamous cell carcinoma: a retrospective study in Northeastern Brazil |
| title_sort | comparative analysis of clinicopathological characteristics in young and elderly patients with oral squamous cell carcinoma a retrospective study in northeastern brazil |
| topic | Squamous Cell Carcinoma of Head and Neck Survival Prognosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242024000102106&lng=en&tlng=en |
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