Aptamer Development for SARS-CoV-2 and Omicron Variants Using the Spike Protein Receptor Binding Domain as a Potential Diagnostic Tool and Therapeutic Agent

Aptamer Development for SARS-CoV-2 and Omicron Variants Using the Spike Protein Receptor Binding Domain as a Potential Diagnostic Tool and Therapeutic Agent

Despite various methods for detecting and treating SARS-CoV-2, affordable and easily applicable solutions are still needed. Aptamers can potentially fill this gap. Here, we establish a workflow to identify aptamers that bind to the spike proteins of SARS-CoV-2, a process applicable to other targets...

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Bibliographic Details
Main Authors: Prasanna V. Shekar, Anuj Kumar, Nirmitee Mulgaonkar, Samneet Kashyap, Gourav Choudhir, Sandun Fernando, Sachin Rustgi
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomolecules
Subjects:
<i>in silico</i> SELEX (systematic evolution of ligands by exponential enrichment)
aptamer
SARS-CoV-2
COVID-19
Online Access:https://www.mdpi.com/2218-273X/15/6/805
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