Recent trends in studying of alcohol-induced liver disease
The aim of review. To analyze main epidemiologic tendencies of development of alcoholic liver disease, mechanisms of its development, mortality in this population of patients. To discuss an option of new targets for treatment of this disease.Original positions. Alcohol abuse is the third leading cau...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2011-12-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1473 |
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| author | I. I. Komkova M. S. Zharkova M. V. Mayevskaya |
| author_facet | I. I. Komkova M. S. Zharkova M. V. Mayevskaya |
| author_sort | I. I. Komkova |
| collection | DOAJ |
| description | The aim of review. To analyze main epidemiologic tendencies of development of alcoholic liver disease, mechanisms of its development, mortality in this population of patients. To discuss an option of new targets for treatment of this disease.Original positions. Alcohol abuse is the third leading cause of morbidity and mortality in the young age. In the studies it was demonstrated, that there is significant difference in death rate of liver cirrhosis between European countries. Disease risk factors include: amount of taken alcohol, its type, frequency of use, female gender, excessive body weight. Besides damaging effect, in response to admission of alcohol processes of protection and neogenesis of the liver through activation of IL-6, IL-22 receptors, STAT-proteins system are initiated. Mechanism of TNFα action, resulting in apoptosis of hepatocytes through activation of acidic sphingomyelinase is investigated.Conclusion. Application of acidic sphingomyelinase, influence on Kupffer's cells phenotype, cannabinoids receptors as new targets for treatment of alcoholic liver disease is possible. At treatment of patients with severe alcohol-induced hepatitis corticosteroids considerably increasing 28-day's survival rate are actively applied. To increase efficacy of treatment of acute alcoholic hepatitis the issue of addition to standard treatment by glucocorticosteroids IL-22 is taken into account. |
| format | Article |
| id | doaj-art-c501b265138043db93a10d35700f7a55 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2011-12-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-c501b265138043db93a10d35700f7a552025-02-10T16:14:31ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732011-12-012163341997Recent trends in studying of alcohol-induced liver diseaseI. I. Komkova0M. S. Zharkova1M. V. Mayevskaya2ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова»ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова»ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова»The aim of review. To analyze main epidemiologic tendencies of development of alcoholic liver disease, mechanisms of its development, mortality in this population of patients. To discuss an option of new targets for treatment of this disease.Original positions. Alcohol abuse is the third leading cause of morbidity and mortality in the young age. In the studies it was demonstrated, that there is significant difference in death rate of liver cirrhosis between European countries. Disease risk factors include: amount of taken alcohol, its type, frequency of use, female gender, excessive body weight. Besides damaging effect, in response to admission of alcohol processes of protection and neogenesis of the liver through activation of IL-6, IL-22 receptors, STAT-proteins system are initiated. Mechanism of TNFα action, resulting in apoptosis of hepatocytes through activation of acidic sphingomyelinase is investigated.Conclusion. Application of acidic sphingomyelinase, influence on Kupffer's cells phenotype, cannabinoids receptors as new targets for treatment of alcoholic liver disease is possible. At treatment of patients with severe alcohol-induced hepatitis corticosteroids considerably increasing 28-day's survival rate are actively applied. To increase efficacy of treatment of acute alcoholic hepatitis the issue of addition to standard treatment by glucocorticosteroids IL-22 is taken into account.https://www.gastro-j.ru/jour/article/view/1473alcoholic liver diseaseil-6il-22stat3kupffer's cells polarizationcb1cb2 |
| spellingShingle | I. I. Komkova M. S. Zharkova M. V. Mayevskaya Recent trends in studying of alcohol-induced liver disease Российский журнал гастроэнтерологии, гепатологии, колопроктологии alcoholic liver disease il-6 il-22 stat3 kupffer's cells polarization cb1 cb2 |
| title | Recent trends in studying of alcohol-induced liver disease |
| title_full | Recent trends in studying of alcohol-induced liver disease |
| title_fullStr | Recent trends in studying of alcohol-induced liver disease |
| title_full_unstemmed | Recent trends in studying of alcohol-induced liver disease |
| title_short | Recent trends in studying of alcohol-induced liver disease |
| title_sort | recent trends in studying of alcohol induced liver disease |
| topic | alcoholic liver disease il-6 il-22 stat3 kupffer's cells polarization cb1 cb2 |
| url | https://www.gastro-j.ru/jour/article/view/1473 |
| work_keys_str_mv | AT iikomkova recenttrendsinstudyingofalcoholinducedliverdisease AT mszharkova recenttrendsinstudyingofalcoholinducedliverdisease AT mvmayevskaya recenttrendsinstudyingofalcoholinducedliverdisease |