A Rare Presentation of Invasive Nontypeable Haemophilus influenzae With Systemic Involvement: A Case Report
Haemophilus influenzae (H. influenzae) is a common organism that causes noninvasive infections in the respiratory tract. Lately, there has been an increasing incidence of invasive diseases with nontypeable strains not covered by Hib vaccines. We discuss a case of a middle-aged male with sickle cell...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/crdi/1817056 |
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| author | Hajra Nosheen Lochan Bellamkonda John George Youssef Abhijeet Ghatol Shagufta Naz Ali |
| author_facet | Hajra Nosheen Lochan Bellamkonda John George Youssef Abhijeet Ghatol Shagufta Naz Ali |
| author_sort | Hajra Nosheen |
| collection | DOAJ |
| description | Haemophilus influenzae (H. influenzae) is a common organism that causes noninvasive infections in the respiratory tract. Lately, there has been an increasing incidence of invasive diseases with nontypeable strains not covered by Hib vaccines. We discuss a case of a middle-aged male with sickle cell trait and gout who presented with altered mentation and polyarthralgia. On investigations, he had H. influenzae bacteremia on two sets of blood cultures with dissemination to meninges and joints, causing acute encephalopathy and polyarthralgia. The initial results of arthrocentesis and lumbar puncture were sterile. However, PCR analysis of the fluid revealed nontypeable H. influenzae. The patient required mechanical ventilation and vasopressor support given sepsis but recovered after extended antibiotics and multiple surgical debridements. Our case highlights the importance of maintaining a high suspicion of invasive disease in decompensated patients and the role of advanced diagnostics in treatment and outcome. |
| format | Article |
| id | doaj-art-c4fdee6ae5864813abe67d0f4f718fc1 |
| institution | DOAJ |
| issn | 2090-6633 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-c4fdee6ae5864813abe67d0f4f718fc12025-08-20T03:12:32ZengWileyCase Reports in Infectious Diseases2090-66332025-01-01202510.1155/crdi/1817056A Rare Presentation of Invasive Nontypeable Haemophilus influenzae With Systemic Involvement: A Case ReportHajra Nosheen0Lochan Bellamkonda1John George Youssef2Abhijeet Ghatol3Shagufta Naz Ali4Internal MedicinePulmonary and Critical CarePulmonary and Critical CarePulmonary and Critical CareInfectious DiseaseHaemophilus influenzae (H. influenzae) is a common organism that causes noninvasive infections in the respiratory tract. Lately, there has been an increasing incidence of invasive diseases with nontypeable strains not covered by Hib vaccines. We discuss a case of a middle-aged male with sickle cell trait and gout who presented with altered mentation and polyarthralgia. On investigations, he had H. influenzae bacteremia on two sets of blood cultures with dissemination to meninges and joints, causing acute encephalopathy and polyarthralgia. The initial results of arthrocentesis and lumbar puncture were sterile. However, PCR analysis of the fluid revealed nontypeable H. influenzae. The patient required mechanical ventilation and vasopressor support given sepsis but recovered after extended antibiotics and multiple surgical debridements. Our case highlights the importance of maintaining a high suspicion of invasive disease in decompensated patients and the role of advanced diagnostics in treatment and outcome.http://dx.doi.org/10.1155/crdi/1817056 |
| spellingShingle | Hajra Nosheen Lochan Bellamkonda John George Youssef Abhijeet Ghatol Shagufta Naz Ali A Rare Presentation of Invasive Nontypeable Haemophilus influenzae With Systemic Involvement: A Case Report Case Reports in Infectious Diseases |
| title | A Rare Presentation of Invasive Nontypeable Haemophilus influenzae With Systemic Involvement: A Case Report |
| title_full | A Rare Presentation of Invasive Nontypeable Haemophilus influenzae With Systemic Involvement: A Case Report |
| title_fullStr | A Rare Presentation of Invasive Nontypeable Haemophilus influenzae With Systemic Involvement: A Case Report |
| title_full_unstemmed | A Rare Presentation of Invasive Nontypeable Haemophilus influenzae With Systemic Involvement: A Case Report |
| title_short | A Rare Presentation of Invasive Nontypeable Haemophilus influenzae With Systemic Involvement: A Case Report |
| title_sort | rare presentation of invasive nontypeable haemophilus influenzae with systemic involvement a case report |
| url | http://dx.doi.org/10.1155/crdi/1817056 |
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