Identification of ERAD-dependent degrons for the endoplasmic reticulum lumen

Identification of ERAD-dependent degrons for the endoplasmic reticulum lumen

Degrons are minimal protein features that are sufficient to target proteins for degradation. In most cases, degrons allow recognition by components of the cytosolic ubiquitin proteasome system. Currently, all of the identified degrons only function within the cytosol. Using Saccharomyces cerevisiae,...

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Bibliographic Details
Main Authors: Rachel Sharninghausen, Jiwon Hwang, Devon D Dennison, Ryan D Baldridge
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-11-01
Series:eLife
Subjects:
degrons
protein degradation
endoplasmic reticulum associated degradation
ERAD
Online Access:https://elifesciences.org/articles/89606
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