Cerebral manifestation and diagnostic dilemma of Rosai-Dorfman disease
Rosai-Dorfman disease (RDD) is a rare, S100-positive histiocytic proliferation, that can cause both nodal and extranodal illness. We present a case of a 53-year-old male patient. Magnetic resonance imaging described a plaque-like meningeal lesion, and the preoperative diagnosis was meningioma. Histo...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | CNS Oncology |
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| Online Access: | https://www.futuremedicine.com/doi/10.2217/cns-2023-0006 |
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| author | Szintia Almási Tamás Pancsa László Tiszlavicz Anita Sejben |
| author_facet | Szintia Almási Tamás Pancsa László Tiszlavicz Anita Sejben |
| author_sort | Szintia Almási |
| collection | DOAJ |
| description | Rosai-Dorfman disease (RDD) is a rare, S100-positive histiocytic proliferation, that can cause both nodal and extranodal illness. We present a case of a 53-year-old male patient. Magnetic resonance imaging described a plaque-like meningeal lesion, and the preoperative diagnosis was meningioma. Histologically, dense infiltration of lymphocytes, plasma cells, and histiocytes was seen, furthermore, the presence of emperipolesis in the sample was pronounced. In the histiocytes nuclear and cytoplasmic positivity with S100 protein, and nuclear positivity with Cyclin D1 was observed. The case was concluded as RDD. Morphological appearance of intracranial RDD with imaging procedures can present a differential diagnostic challenge. The correct diagnosis is based on the presence of histiocytes with emperipolesis, and properly defined immunohistochemical characteristics. |
| format | Article |
| id | doaj-art-c4f5f235e4d6444ea4f5762bc5517917 |
| institution | OA Journals |
| issn | 2045-0907 2045-0915 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | CNS Oncology |
| spelling | doaj-art-c4f5f235e4d6444ea4f5762bc55179172025-08-20T02:26:02ZengTaylor & Francis GroupCNS Oncology2045-09072045-09152023-12-0112410.2217/cns-2023-0006Cerebral manifestation and diagnostic dilemma of Rosai-Dorfman diseaseSzintia Almási0Tamás Pancsa1László Tiszlavicz2Anita Sejben31Department of Pathology, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, 6725, Hungary1Department of Pathology, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, 6725, Hungary1Department of Pathology, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, 6725, Hungary1Department of Pathology, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, 6725, HungaryRosai-Dorfman disease (RDD) is a rare, S100-positive histiocytic proliferation, that can cause both nodal and extranodal illness. We present a case of a 53-year-old male patient. Magnetic resonance imaging described a plaque-like meningeal lesion, and the preoperative diagnosis was meningioma. Histologically, dense infiltration of lymphocytes, plasma cells, and histiocytes was seen, furthermore, the presence of emperipolesis in the sample was pronounced. In the histiocytes nuclear and cytoplasmic positivity with S100 protein, and nuclear positivity with Cyclin D1 was observed. The case was concluded as RDD. Morphological appearance of intracranial RDD with imaging procedures can present a differential diagnostic challenge. The correct diagnosis is based on the presence of histiocytes with emperipolesis, and properly defined immunohistochemical characteristics.https://www.futuremedicine.com/doi/10.2217/cns-2023-0006histiocytosisIgG4Rosai-Dorfman diseaseS100 |
| spellingShingle | Szintia Almási Tamás Pancsa László Tiszlavicz Anita Sejben Cerebral manifestation and diagnostic dilemma of Rosai-Dorfman disease CNS Oncology histiocytosis IgG4 Rosai-Dorfman disease S100 |
| title | Cerebral manifestation and diagnostic dilemma of Rosai-Dorfman disease |
| title_full | Cerebral manifestation and diagnostic dilemma of Rosai-Dorfman disease |
| title_fullStr | Cerebral manifestation and diagnostic dilemma of Rosai-Dorfman disease |
| title_full_unstemmed | Cerebral manifestation and diagnostic dilemma of Rosai-Dorfman disease |
| title_short | Cerebral manifestation and diagnostic dilemma of Rosai-Dorfman disease |
| title_sort | cerebral manifestation and diagnostic dilemma of rosai dorfman disease |
| topic | histiocytosis IgG4 Rosai-Dorfman disease S100 |
| url | https://www.futuremedicine.com/doi/10.2217/cns-2023-0006 |
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