Multifocal Infantile Hemangiomas Treated by Oral Itraconazole: A Case Report

We describe a case of a 2-month-old girl presented with more than 60 papules and nodules of hemangiomas involving the skin of the sclera, endocanthion, lower lip, and labium majus pudenda without visceral hemangiomas and laboratory abnormality. A skin biopsy showed numerous scattered, clearly limit...

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Main Authors: Wei Wu, Sushmita Pradhan, Xin Ran, Yanxia Cai, Jinying Xie, Shunting Zhou, Yuping Ran
Format: Article
Language:English
Published: Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON) 2022-03-01
Series:Nepal Journal of Dermatology, Venereology & Leprology
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Online Access:https://www.nepjol.info/index.php/NJDVL/article/view/42313
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author Wei Wu
Sushmita Pradhan
Xin Ran
Yanxia Cai
Jinying Xie
Shunting Zhou
Yuping Ran
author_facet Wei Wu
Sushmita Pradhan
Xin Ran
Yanxia Cai
Jinying Xie
Shunting Zhou
Yuping Ran
author_sort Wei Wu
collection DOAJ
description We describe a case of a 2-month-old girl presented with more than 60 papules and nodules of hemangiomas involving the skin of the sclera, endocanthion, lower lip, and labium majus pudenda without visceral hemangiomas and laboratory abnormality. A skin biopsy showed numerous scattered, clearly limited, irregular cellular lobules in the dermis circumvoluted into capillaries comprising incomplete vessel walls, which was consistent with a diagnosis of multifocal cutaneous infantile hemangioma. Oral treatment with itraconazole (5mg/kg/day) for 26 weeks resulted in predominantly involution of the skin hemangiomas. We would like to report a rare case of multifocal cutaneous infantile hemangioma, successfully treated with oral itraconazole.
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id doaj-art-c4f4cda037a04888a9fc6d4b30c526bf
institution Kabale University
issn 2091-0231
2091-167X
language English
publishDate 2022-03-01
publisher Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)
record_format Article
series Nepal Journal of Dermatology, Venereology & Leprology
spelling doaj-art-c4f4cda037a04888a9fc6d4b30c526bf2025-08-23T10:04:00ZengSociety of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)Nepal Journal of Dermatology, Venereology & Leprology2091-02312091-167X2022-03-0120110.3126/njdvl.v20i1.42313Multifocal Infantile Hemangiomas Treated by Oral Itraconazole: A Case ReportWei Wu0Sushmita Pradhan1https://orcid.org/0000-0002-7569-4719Xin Ran2https://orcid.org/0000-0001-8833-9006Yanxia Cai3Jinying Xie4Shunting Zhou5Yuping Ran6https://orcid.org/0000-0002-9382-0571 Hospital of Guangdong Medical University, Zhanjiang, China West China Hospital, Sichuan University, Chengdu, China and Province Hospital, Karnali Province, Birendranagar, Surkhet, Nepal West China Hospital, Sichuan University, Chengdu, ChinaHospital of Guangdong Medical University, Zhanjiang, China Hospital of Guangdong Medical University, Zhanjiang, ChinaHospital of Guangdong Medical University, Zhanjiang, China West China Hospital, Sichuan University, Chengdu, China We describe a case of a 2-month-old girl presented with more than 60 papules and nodules of hemangiomas involving the skin of the sclera, endocanthion, lower lip, and labium majus pudenda without visceral hemangiomas and laboratory abnormality. A skin biopsy showed numerous scattered, clearly limited, irregular cellular lobules in the dermis circumvoluted into capillaries comprising incomplete vessel walls, which was consistent with a diagnosis of multifocal cutaneous infantile hemangioma. Oral treatment with itraconazole (5mg/kg/day) for 26 weeks resulted in predominantly involution of the skin hemangiomas. We would like to report a rare case of multifocal cutaneous infantile hemangioma, successfully treated with oral itraconazole. https://www.nepjol.info/index.php/NJDVL/article/view/42313Infantile HemangiomaItraconazolePropranolol
spellingShingle Wei Wu
Sushmita Pradhan
Xin Ran
Yanxia Cai
Jinying Xie
Shunting Zhou
Yuping Ran
Multifocal Infantile Hemangiomas Treated by Oral Itraconazole: A Case Report
Nepal Journal of Dermatology, Venereology & Leprology
Infantile Hemangioma
Itraconazole
Propranolol
title Multifocal Infantile Hemangiomas Treated by Oral Itraconazole: A Case Report
title_full Multifocal Infantile Hemangiomas Treated by Oral Itraconazole: A Case Report
title_fullStr Multifocal Infantile Hemangiomas Treated by Oral Itraconazole: A Case Report
title_full_unstemmed Multifocal Infantile Hemangiomas Treated by Oral Itraconazole: A Case Report
title_short Multifocal Infantile Hemangiomas Treated by Oral Itraconazole: A Case Report
title_sort multifocal infantile hemangiomas treated by oral itraconazole a case report
topic Infantile Hemangioma
Itraconazole
Propranolol
url https://www.nepjol.info/index.php/NJDVL/article/view/42313
work_keys_str_mv AT weiwu multifocalinfantilehemangiomastreatedbyoralitraconazoleacasereport
AT sushmitapradhan multifocalinfantilehemangiomastreatedbyoralitraconazoleacasereport
AT xinran multifocalinfantilehemangiomastreatedbyoralitraconazoleacasereport
AT yanxiacai multifocalinfantilehemangiomastreatedbyoralitraconazoleacasereport
AT jinyingxie multifocalinfantilehemangiomastreatedbyoralitraconazoleacasereport
AT shuntingzhou multifocalinfantilehemangiomastreatedbyoralitraconazoleacasereport
AT yupingran multifocalinfantilehemangiomastreatedbyoralitraconazoleacasereport