Dietary lipids are largely deposited in skin and rapidly affect insulating properties
Abstract Skin is a regulatory hub for energy expenditure and metabolism, and alteration of lipid metabolism enzymes in skin impacts thermogenesis and obesogenesis in mice. Here we show that thermal properties of skin are highly reactive to diet: within three days, a high fat diet reduces heat transf...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-59869-x |
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| author | Nick Riley Ildiko Kasza Isabel D. K. Hermsmeyer Michaela E. Trautman Greg Barrett-Wilt Raghav Jain Judith A. Simcox Chi-Liang E. Yen Ormond A. MacDougald Dudley W. Lamming Caroline M. Alexander |
| author_facet | Nick Riley Ildiko Kasza Isabel D. K. Hermsmeyer Michaela E. Trautman Greg Barrett-Wilt Raghav Jain Judith A. Simcox Chi-Liang E. Yen Ormond A. MacDougald Dudley W. Lamming Caroline M. Alexander |
| author_sort | Nick Riley |
| collection | DOAJ |
| description | Abstract Skin is a regulatory hub for energy expenditure and metabolism, and alteration of lipid metabolism enzymes in skin impacts thermogenesis and obesogenesis in mice. Here we show that thermal properties of skin are highly reactive to diet: within three days, a high fat diet reduces heat transfer through skin. In contrast, a dietary manipulation that prevents obesity accelerates energy loss through skins. We find that skin is the largest target for dietary fat delivery, and that dietary triglyceride is assimilated by epidermis and dermal white adipose tissue, persisting for weeks after feeding. With caloric-restriction, mouse skins thin and assimilation of circulating lipids decreases. Using multi-modal lipid profiling, keratinocytes and sebocytes are implicated in lipid changes, which correlate with thermal function. We propose that skin should be routinely included in physiological studies of lipid metabolism, given the size of the skin lipid reservoir and its adaptable functionality. |
| format | Article |
| id | doaj-art-c4f38bf4adaf4e1695bbe5b94feb8356 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-c4f38bf4adaf4e1695bbe5b94feb83562025-08-20T03:53:57ZengNature PortfolioNature Communications2041-17232025-05-0116111710.1038/s41467-025-59869-xDietary lipids are largely deposited in skin and rapidly affect insulating propertiesNick Riley0Ildiko Kasza1Isabel D. K. Hermsmeyer2Michaela E. Trautman3Greg Barrett-Wilt4Raghav Jain5Judith A. Simcox6Chi-Liang E. Yen7Ormond A. MacDougald8Dudley W. Lamming9Caroline M. Alexander10McArdle Laboratory for Cancer Research, University of Wisconsin-MadisonMcArdle Laboratory for Cancer Research, University of Wisconsin-MadisonDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Medicine, University of Wisconsin-MadisonBiochemistry Mass Spectrometry CoreDepartment of Biochemistry, University of Wisconsin-MadisonDepartment of Biochemistry, University of Wisconsin-MadisonDepartment of Nutritional Sciences, University of Wisconsin-MadisonDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Medicine, University of Wisconsin-MadisonMcArdle Laboratory for Cancer Research, University of Wisconsin-MadisonAbstract Skin is a regulatory hub for energy expenditure and metabolism, and alteration of lipid metabolism enzymes in skin impacts thermogenesis and obesogenesis in mice. Here we show that thermal properties of skin are highly reactive to diet: within three days, a high fat diet reduces heat transfer through skin. In contrast, a dietary manipulation that prevents obesity accelerates energy loss through skins. We find that skin is the largest target for dietary fat delivery, and that dietary triglyceride is assimilated by epidermis and dermal white adipose tissue, persisting for weeks after feeding. With caloric-restriction, mouse skins thin and assimilation of circulating lipids decreases. Using multi-modal lipid profiling, keratinocytes and sebocytes are implicated in lipid changes, which correlate with thermal function. We propose that skin should be routinely included in physiological studies of lipid metabolism, given the size of the skin lipid reservoir and its adaptable functionality.https://doi.org/10.1038/s41467-025-59869-x |
| spellingShingle | Nick Riley Ildiko Kasza Isabel D. K. Hermsmeyer Michaela E. Trautman Greg Barrett-Wilt Raghav Jain Judith A. Simcox Chi-Liang E. Yen Ormond A. MacDougald Dudley W. Lamming Caroline M. Alexander Dietary lipids are largely deposited in skin and rapidly affect insulating properties Nature Communications |
| title | Dietary lipids are largely deposited in skin and rapidly affect insulating properties |
| title_full | Dietary lipids are largely deposited in skin and rapidly affect insulating properties |
| title_fullStr | Dietary lipids are largely deposited in skin and rapidly affect insulating properties |
| title_full_unstemmed | Dietary lipids are largely deposited in skin and rapidly affect insulating properties |
| title_short | Dietary lipids are largely deposited in skin and rapidly affect insulating properties |
| title_sort | dietary lipids are largely deposited in skin and rapidly affect insulating properties |
| url | https://doi.org/10.1038/s41467-025-59869-x |
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