Metformin hydrochloride laden nanostructured lipid carriers: A promising strategy for skin diseases
Abstract Metformin hydrochloride (MTF) has pharmacological properties for managing inflammatory skin conditions. MTF is a hydrophilic medication. Accordingly, embedding MTF into lipid carriers for enhancing skin penetration presents a challenge. The study aims to optimize the loading of MTF into nan...
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Universidade de São Paulo
2025-01-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100319&lng=en&tlng=en |
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| author | Reem Y. Mahran Ehab A Fouad Sozan S Tous Nermin E. Eleraky |
| author_facet | Reem Y. Mahran Ehab A Fouad Sozan S Tous Nermin E. Eleraky |
| author_sort | Reem Y. Mahran |
| collection | DOAJ |
| description | Abstract Metformin hydrochloride (MTF) has pharmacological properties for managing inflammatory skin conditions. MTF is a hydrophilic medication. Accordingly, embedding MTF into lipid carriers for enhancing skin penetration presents a challenge. The study aims to optimize the loading of MTF into nanostructured lipid carriers (NLCs) using a 22 full factorial design, employing the solvent injection technique. The NLCs were evaluated for encapsulation efficiency, hydrodynamic diameter, zeta potential, and polydispersity index. Alkalinization of the aqueous phase (pH = 12.5) resulted in maximizing the entrapment of MTF within NLCs. Furthermore, the tested solid lipids impacted the encapsulation of MTF based on their hydrophilic-lipophilic balance. The optimized formulation is composed of a lipid phase incorporating beeswax (75 mg), oleic acid (25 mg), and Span 60 (1% w/w), and an aqueous phase comprised of 1% w/w Tween 80, pH 12.5. The selected formula attained an entrapment efficiency of 53.68 ± 0.27%, a particle size of 333.0 ± 6.4 nm, and a negative surface charge, indicating adequate particles` stability. DSC and Molecular docking analyses confirmed the MTF incorporation within the lipid phase. The outcomes emphasize the importance of optimizing investigations in developing a viable delivery system for MTF to boost its permeation across the skin layers. |
| format | Article |
| id | doaj-art-c4f332a0837643d78cfa11fde5c4415c |
| institution | Kabale University |
| issn | 2175-9790 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj-art-c4f332a0837643d78cfa11fde5c4415c2025-01-21T07:41:51ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902025-01-016110.1590/s2175-97902025e24146Metformin hydrochloride laden nanostructured lipid carriers: A promising strategy for skin diseasesReem Y. Mahranhttps://orcid.org/0009-0001-0567-8246Ehab A FouadSozan S TousNermin E. Elerakyhttps://orcid.org/0000-0001-5218-4575Abstract Metformin hydrochloride (MTF) has pharmacological properties for managing inflammatory skin conditions. MTF is a hydrophilic medication. Accordingly, embedding MTF into lipid carriers for enhancing skin penetration presents a challenge. The study aims to optimize the loading of MTF into nanostructured lipid carriers (NLCs) using a 22 full factorial design, employing the solvent injection technique. The NLCs were evaluated for encapsulation efficiency, hydrodynamic diameter, zeta potential, and polydispersity index. Alkalinization of the aqueous phase (pH = 12.5) resulted in maximizing the entrapment of MTF within NLCs. Furthermore, the tested solid lipids impacted the encapsulation of MTF based on their hydrophilic-lipophilic balance. The optimized formulation is composed of a lipid phase incorporating beeswax (75 mg), oleic acid (25 mg), and Span 60 (1% w/w), and an aqueous phase comprised of 1% w/w Tween 80, pH 12.5. The selected formula attained an entrapment efficiency of 53.68 ± 0.27%, a particle size of 333.0 ± 6.4 nm, and a negative surface charge, indicating adequate particles` stability. DSC and Molecular docking analyses confirmed the MTF incorporation within the lipid phase. The outcomes emphasize the importance of optimizing investigations in developing a viable delivery system for MTF to boost its permeation across the skin layers.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100319&lng=en&tlng=enLipid nanoparticlesNanostructured lipid carriers (NLCs)Metformin HydrochlorideMolecular dockingFactorial design |
| spellingShingle | Reem Y. Mahran Ehab A Fouad Sozan S Tous Nermin E. Eleraky Metformin hydrochloride laden nanostructured lipid carriers: A promising strategy for skin diseases Brazilian Journal of Pharmaceutical Sciences Lipid nanoparticles Nanostructured lipid carriers (NLCs) Metformin Hydrochloride Molecular docking Factorial design |
| title | Metformin hydrochloride laden nanostructured lipid carriers: A promising strategy for skin diseases |
| title_full | Metformin hydrochloride laden nanostructured lipid carriers: A promising strategy for skin diseases |
| title_fullStr | Metformin hydrochloride laden nanostructured lipid carriers: A promising strategy for skin diseases |
| title_full_unstemmed | Metformin hydrochloride laden nanostructured lipid carriers: A promising strategy for skin diseases |
| title_short | Metformin hydrochloride laden nanostructured lipid carriers: A promising strategy for skin diseases |
| title_sort | metformin hydrochloride laden nanostructured lipid carriers a promising strategy for skin diseases |
| topic | Lipid nanoparticles Nanostructured lipid carriers (NLCs) Metformin Hydrochloride Molecular docking Factorial design |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502025000100319&lng=en&tlng=en |
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