Insulin-like Growth Factor-1 and Calcium Ion Levels are Negatively Associated with Serum β-Cross Laps in Multi-transfused β-thalassemia Major Patients
BACKGROUND: Thalassemia patients with repeated transfusions (multi-transfusion) are often at risk of experiencing early osteoporosis. Several studies have demonstrated that osteoporosis in these individuals was associated with altered bone remodeling, characterized by decreased insulin-like growth f...
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Secretariat of The Indonesian Biomedical Journal
2025-08-01
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| Series: | Indonesian Biomedical Journal |
| Online Access: | https://inabj.org/index.php/ibj/article/view/3706 |
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| author | Sabar Widodo Nyoman Suci Widyastiti Edward Kurnia Setiawan Limijadi Meita Hendrianingtyas Dwi Retnoningrum Ariosta Ariosta Yetty Movieta Nency |
| author_facet | Sabar Widodo Nyoman Suci Widyastiti Edward Kurnia Setiawan Limijadi Meita Hendrianingtyas Dwi Retnoningrum Ariosta Ariosta Yetty Movieta Nency |
| author_sort | Sabar Widodo |
| collection | DOAJ |
| description | BACKGROUND: Thalassemia patients with repeated transfusions (multi-transfusion) are often at risk of experiencing early osteoporosis. Several studies have demonstrated that osteoporosis in these individuals was associated with altered bone remodeling, characterized by decreased insulin-like growth factor-1 (IGF-1) and serum calcium ions, as well as increased serum β-Cross Laps (β-CTx) levels. Despite the prevalence of this condition, there is limited literature on the relationship between IGF-1 levels and calcium ions with β-CTx. Therefore, this study was conducted to examine the relationship between IGF-1 and calcium ions levels with serum β-CTx in multi-transfused β-thalassemia major patients.
METHODS: A cross sectional study involved 29 thalassemia patients with multiple transfusions, aged 2-18 years, that were selected from the electronic medical records. Calcium ion levels were examined using ion selective electrode method. Subsequently, IGF-1 and serum β-CTx levels were examined by enzyme-linked immunosorbent assay (ELISA), and the data were analyzed using the Pearson correlation test.
RESULTS: The results showed that the mean serum IGF-1 levels, calcium ion, and β-CTx were 20.11±20.763 ng/mL, 1.26±0.07 mmol/L, and 9330.40±1696.76 ng/mL, respectively. Statistical analysis showed a significant relationship between the levels of IGF-1 (r=-0.573; p=0.001) and calcium ion (r=-0.373; p=0.046) with serum β-CTx. A moderate negative relationship was found between IGF-1 levels and β-CTx, while calcium ion levels and β-CTx showed a weak negative relationship.
CONCLUSION: A moderate negative correlation between IGF-1 and serum β-CTx, and a weak negative correlation between calcium ion and serum β-CTx suggest that IGF-1 and calcium ions may serve as potential indicators of bone turnover and osteoporosis risk in multi-transfused β-thalassemia major patients, underscoring their potential role in routine clinical evaluations.
KEYWORDS: miR-200a expression, NO level, early-onset preeclampsia, late-onset preeclampsia |
| format | Article |
| id | doaj-art-c4f2ad4aa4494fd683b0ea3ac22cf3fc |
| institution | Kabale University |
| issn | 2085-3297 2355-9179 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Secretariat of The Indonesian Biomedical Journal |
| record_format | Article |
| series | Indonesian Biomedical Journal |
| spelling | doaj-art-c4f2ad4aa4494fd683b0ea3ac22cf3fc2025-08-26T04:21:46ZengSecretariat of The Indonesian Biomedical JournalIndonesian Biomedical Journal2085-32972355-91792025-08-01174382810.18585/inabj.v17i4.3706650Insulin-like Growth Factor-1 and Calcium Ion Levels are Negatively Associated with Serum β-Cross Laps in Multi-transfused β-thalassemia Major PatientsSabar Widodo0Nyoman Suci Widyastiti1Edward Kurnia Setiawan Limijadi2Meita Hendrianingtyas3Dwi Retnoningrum4Ariosta Ariosta5Yetty Movieta Nency6Clinical Pathology Residency Program, Faculty of Medicine, Universitas Diponegoro, Jl. Prof. Soedarto, Semarang 50275Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Jl. Prof. Soedarto, Semarang 50275Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Jl. Prof. Soedarto, Semarang 50275Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Jl. Prof. Soedarto, Semarang 50275Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Jl. Prof. Soedarto, Semarang 50275Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro, Jl. Prof. Soedarto, Semarang 50275Department of Child Health, Faculty of Medicine, Universitas Diponegoro, Jl. Prof. Soedarto, Semarang 50275BACKGROUND: Thalassemia patients with repeated transfusions (multi-transfusion) are often at risk of experiencing early osteoporosis. Several studies have demonstrated that osteoporosis in these individuals was associated with altered bone remodeling, characterized by decreased insulin-like growth factor-1 (IGF-1) and serum calcium ions, as well as increased serum β-Cross Laps (β-CTx) levels. Despite the prevalence of this condition, there is limited literature on the relationship between IGF-1 levels and calcium ions with β-CTx. Therefore, this study was conducted to examine the relationship between IGF-1 and calcium ions levels with serum β-CTx in multi-transfused β-thalassemia major patients. METHODS: A cross sectional study involved 29 thalassemia patients with multiple transfusions, aged 2-18 years, that were selected from the electronic medical records. Calcium ion levels were examined using ion selective electrode method. Subsequently, IGF-1 and serum β-CTx levels were examined by enzyme-linked immunosorbent assay (ELISA), and the data were analyzed using the Pearson correlation test. RESULTS: The results showed that the mean serum IGF-1 levels, calcium ion, and β-CTx were 20.11±20.763 ng/mL, 1.26±0.07 mmol/L, and 9330.40±1696.76 ng/mL, respectively. Statistical analysis showed a significant relationship between the levels of IGF-1 (r=-0.573; p=0.001) and calcium ion (r=-0.373; p=0.046) with serum β-CTx. A moderate negative relationship was found between IGF-1 levels and β-CTx, while calcium ion levels and β-CTx showed a weak negative relationship. CONCLUSION: A moderate negative correlation between IGF-1 and serum β-CTx, and a weak negative correlation between calcium ion and serum β-CTx suggest that IGF-1 and calcium ions may serve as potential indicators of bone turnover and osteoporosis risk in multi-transfused β-thalassemia major patients, underscoring their potential role in routine clinical evaluations. KEYWORDS: miR-200a expression, NO level, early-onset preeclampsia, late-onset preeclampsiahttps://inabj.org/index.php/ibj/article/view/3706 |
| spellingShingle | Sabar Widodo Nyoman Suci Widyastiti Edward Kurnia Setiawan Limijadi Meita Hendrianingtyas Dwi Retnoningrum Ariosta Ariosta Yetty Movieta Nency Insulin-like Growth Factor-1 and Calcium Ion Levels are Negatively Associated with Serum β-Cross Laps in Multi-transfused β-thalassemia Major Patients Indonesian Biomedical Journal |
| title | Insulin-like Growth Factor-1 and Calcium Ion Levels are Negatively Associated with Serum β-Cross Laps in Multi-transfused β-thalassemia Major Patients |
| title_full | Insulin-like Growth Factor-1 and Calcium Ion Levels are Negatively Associated with Serum β-Cross Laps in Multi-transfused β-thalassemia Major Patients |
| title_fullStr | Insulin-like Growth Factor-1 and Calcium Ion Levels are Negatively Associated with Serum β-Cross Laps in Multi-transfused β-thalassemia Major Patients |
| title_full_unstemmed | Insulin-like Growth Factor-1 and Calcium Ion Levels are Negatively Associated with Serum β-Cross Laps in Multi-transfused β-thalassemia Major Patients |
| title_short | Insulin-like Growth Factor-1 and Calcium Ion Levels are Negatively Associated with Serum β-Cross Laps in Multi-transfused β-thalassemia Major Patients |
| title_sort | insulin like growth factor 1 and calcium ion levels are negatively associated with serum β cross laps in multi transfused β thalassemia major patients |
| url | https://inabj.org/index.php/ibj/article/view/3706 |
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