Effectiveness of analgesic ear drops as add-on treatment to oral analgesics in children with acute otitis media: study protocol of the OPTIMA pragmatic randomised controlled trial

Effectiveness of analgesic ear drops as add-on treatment to oral analgesics in children with acute otitis media: study protocol of the OPTIMA pragmatic randomised controlled trial

Introduction Ear pain is the most prominent symptom of childhood acute otitis media (AOM). To control the pain and reduce reliance on antibiotics, evidence of effectiveness for alternative interventions is urgently needed. This trial aims to investigate whether analgesic ear drops added to usual car...

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Main Authors: Paul Little, Alastair D Hay, Lucy Yardley, G Ardine de Wit, Nicolaas P A Zuithoff, Sibyl Anthierens, Roderick P Venekamp, Anne G M Schilder, Roger A M J Damoiseaux, Elisabeth A M Sanders, Saskia Hullegie, Joline L H de Sévaux
Format: Article
Language:English
Published: BMJ Publishing Group 2023-02-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/13/2/e062071.full
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