Urease Levels and Gastritis Stage in Dyspeptic Patients
Background: Dyspepsia is a frequent main symptom of inpatients and outpatients scenario in Indonesia. However, the number of endoscopy facilities are still low, thus the use of non-invasive method to detect gastritis is necessary. We measured the relationship between urease levels and the stage of g...
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Interna Publishing
2022-04-01
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| Series: | Acta Medica Indonesiana |
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| Online Access: | http://www.actamedindones.org/index.php/ijim/article/view/1927 |
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| author | Muhammad Miftahussurur Chyntia Dewi Maharani Putri Titong Sugihartono Ari Fahrial Syam Herry Purbayu Diah Priyantini Hartono Kahar Yudith Annisa Ayu Rezkitha Iswan Abbas Nusi Poernomo Boedi Setiawan Ummi Maimunah Langgeng Agung Waskito Ulfa Kholili Budi Widodo Amie Vidyani Husin Thamrin Gontar Alamsyah Siregar Reny I’tishom Tomohisa Uchida Yoshio Yamaoka |
| author_facet | Muhammad Miftahussurur Chyntia Dewi Maharani Putri Titong Sugihartono Ari Fahrial Syam Herry Purbayu Diah Priyantini Hartono Kahar Yudith Annisa Ayu Rezkitha Iswan Abbas Nusi Poernomo Boedi Setiawan Ummi Maimunah Langgeng Agung Waskito Ulfa Kholili Budi Widodo Amie Vidyani Husin Thamrin Gontar Alamsyah Siregar Reny I’tishom Tomohisa Uchida Yoshio Yamaoka |
| author_sort | Muhammad Miftahussurur |
| collection | DOAJ |
| description | Background: Dyspepsia is a frequent main symptom of inpatients and outpatients scenario in Indonesia. However, the number of endoscopy facilities are still low, thus the use of non-invasive method to detect gastritis is necessary. We measured the relationship between urease levels and the stage of gastritis in dyspeptic adult patients. Methods: A cross-sectional study included outpatient dyspepsia patient from November 2018 to February 2019. We examined 14C-Urea Breath Test (UBT) and determined the stage of gastritis based on the Updated Sydney System classification. Results: The urease level of acute and chronic gastritis positive patients were higher than negative patients (p = 0.001, r = 0.353; p <0.0001, r = 0.433, respectively). The AUC value of 14C-UBT to detect acute, chronic, and atrophic gastritis are 0.889, 0.632 and 0.544, respectively. The best cut-off points of 14C-UBT to predict acute gastritis was ≥26.50δ‰ with sensitivity and specificity being 88.89% and 63.95%, respectively. Whereas the best cut-off points for chronic gastritis was ≥34.50δ‰ with 82.89% sensitivity, 63.16% specificity. As for atrophic gastritis, it showed very low AUC value, hence it is not a sufficient test modality to predict atrophic gastritis cases. Conclusion: 14C-UBT is sufficient for predicting acute or chronic gastritis but not for atrophic gastritis. |
| format | Article |
| id | doaj-art-c4f0040cd44e48bd831374c2f7ba3cf6 |
| institution | OA Journals |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2022-04-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-c4f0040cd44e48bd831374c2f7ba3cf62025-08-20T02:37:17ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322022-04-01541487Urease Levels and Gastritis Stage in Dyspeptic PatientsMuhammad Miftahussurur0Chyntia Dewi Maharani Putri1Titong Sugihartono2Ari Fahrial Syam3Herry Purbayu4Diah Priyantini5Hartono Kahar6Yudith Annisa Ayu Rezkitha7Iswan Abbas Nusi8Poernomo Boedi Setiawan9Ummi Maimunah10Langgeng Agung Waskito11Ulfa Kholili12Budi Widodo13Amie Vidyani14Husin Thamrin15Gontar Alamsyah Siregar16Reny I’tishom17Tomohisa Uchida18Yoshio Yamaoka191. Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia 2. Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia 3. Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu 879-5593, JapanDivision of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, IndonesiaDivision of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, IndonesiaDivision of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta 10430, IndonesiaDivision of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, IndonesiaFaculty of Nursing, Universitas Airlangga, Surabaya 60115, IndonesiaDepartment of Clinical Pathology, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60131, Indonesia1. Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia 2. Faculty of Medicine, Muhammadiyah University of Surabaya, Surabaya 60113, IndonesiaDivision of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, IndonesiaDivision of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, IndonesiaDivision of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, IndonesiaInstitute of Tropical Disease, Universitas Airlangga, Surabaya 60115, IndonesiaDivision of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, IndonesiaDivision of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, IndonesiaDivision of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, IndonesiaDivision of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, IndonesiaDivision of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, North Sumatra University, Medan, 20115, IndonesiaDepartment of Medical Biology, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, IndonesiaDepartment of Molecular Pathology, Oita University Faculty of Medicine, Yufu 879-5593, Japan1. Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia 2. Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu 879-5593, JapanBackground: Dyspepsia is a frequent main symptom of inpatients and outpatients scenario in Indonesia. However, the number of endoscopy facilities are still low, thus the use of non-invasive method to detect gastritis is necessary. We measured the relationship between urease levels and the stage of gastritis in dyspeptic adult patients. Methods: A cross-sectional study included outpatient dyspepsia patient from November 2018 to February 2019. We examined 14C-Urea Breath Test (UBT) and determined the stage of gastritis based on the Updated Sydney System classification. Results: The urease level of acute and chronic gastritis positive patients were higher than negative patients (p = 0.001, r = 0.353; p <0.0001, r = 0.433, respectively). The AUC value of 14C-UBT to detect acute, chronic, and atrophic gastritis are 0.889, 0.632 and 0.544, respectively. The best cut-off points of 14C-UBT to predict acute gastritis was ≥26.50δ‰ with sensitivity and specificity being 88.89% and 63.95%, respectively. Whereas the best cut-off points for chronic gastritis was ≥34.50δ‰ with 82.89% sensitivity, 63.16% specificity. As for atrophic gastritis, it showed very low AUC value, hence it is not a sufficient test modality to predict atrophic gastritis cases. Conclusion: 14C-UBT is sufficient for predicting acute or chronic gastritis but not for atrophic gastritis.http://www.actamedindones.org/index.php/ijim/article/view/1927DyspepsiaGastritis severityUrea Breath TestCancer |
| spellingShingle | Muhammad Miftahussurur Chyntia Dewi Maharani Putri Titong Sugihartono Ari Fahrial Syam Herry Purbayu Diah Priyantini Hartono Kahar Yudith Annisa Ayu Rezkitha Iswan Abbas Nusi Poernomo Boedi Setiawan Ummi Maimunah Langgeng Agung Waskito Ulfa Kholili Budi Widodo Amie Vidyani Husin Thamrin Gontar Alamsyah Siregar Reny I’tishom Tomohisa Uchida Yoshio Yamaoka Urease Levels and Gastritis Stage in Dyspeptic Patients Acta Medica Indonesiana Dyspepsia Gastritis severity Urea Breath Test Cancer |
| title | Urease Levels and Gastritis Stage in Dyspeptic Patients |
| title_full | Urease Levels and Gastritis Stage in Dyspeptic Patients |
| title_fullStr | Urease Levels and Gastritis Stage in Dyspeptic Patients |
| title_full_unstemmed | Urease Levels and Gastritis Stage in Dyspeptic Patients |
| title_short | Urease Levels and Gastritis Stage in Dyspeptic Patients |
| title_sort | urease levels and gastritis stage in dyspeptic patients |
| topic | Dyspepsia Gastritis severity Urea Breath Test Cancer |
| url | http://www.actamedindones.org/index.php/ijim/article/view/1927 |
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