Acute myocardial infarction-related mortality among older adults (≥65 years) with malignancy in the U.S. from 1999 to 2020
Background: Acute Myocardial Infarction (AMI) in malignancy is a global threat, causing significant mortality and economic burden. They share common risk factors, highlighting the urgency of addressing this critical issue. Objective: This study analyzed demographic trends and disparities in mortalit...
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Elsevier
2025-06-01
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| Series: | International Journal of Cardiology. Cardiovascular Risk and Prevention |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772487525000303 |
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| author | Muhammad Abdullah Naveed Sivaram Neppala Himaja Dutt Chigurupati Ahila Ali Muhammad Omer Rehan Ayman Fath Bazil Azeem Rabia Iqbal Manahil Mubeen Hamza Naveed Muhammad Naveed Uz Zafar Mushood Ahmed Jamal S. Rana Brijesh Patel |
| author_facet | Muhammad Abdullah Naveed Sivaram Neppala Himaja Dutt Chigurupati Ahila Ali Muhammad Omer Rehan Ayman Fath Bazil Azeem Rabia Iqbal Manahil Mubeen Hamza Naveed Muhammad Naveed Uz Zafar Mushood Ahmed Jamal S. Rana Brijesh Patel |
| author_sort | Muhammad Abdullah Naveed |
| collection | DOAJ |
| description | Background: Acute Myocardial Infarction (AMI) in malignancy is a global threat, causing significant mortality and economic burden. They share common risk factors, highlighting the urgency of addressing this critical issue. Objective: This study analyzed demographic trends and disparities in mortality rates due to AMI in malignancy among adults aged 65 and older from 1999 to 2020. Methods: We used the CDC WONDER database to analyze Age-adjusted mortality rates (AAMRs) for AMI in malignancy patients (ICD-10 I21, C00-C97) from 1999 to 2020, stratifying by sex, race, geography, and metropolitan status. We calculated Average Annual Percentage Changes (AAPCs) and Annual Percentage Changes (APCs) per 100,000 with 95 % confidence intervals (CI) using Joinpoint regression. Results: Between 1999 and 2020, AMI in malignancy accounted for 172,691 deaths among adults aged ≥65 years, with the majority of deaths occurring in medical facilities (56.9 %). The overall AAMR for AMI in malignancy-related deaths decreased from 30.2 in 1999 to 14.2 in 2020, with an AAPC of −3.90 (p < 0.000001). Men showed higher AAMRs than women (28.6 vs. 12.3), with a more pronounced decrease in men (AAPC: 4.22, p < 0.000001) compared to women (AAPC: 3.78, p < 0.000001). Black individuals have the highest AAMR (22.7), followed by Whites (19.3). Arkansas had the highest AAMR (32.3), while Nevada had the lowest (8.1), with the Northeastern region having the highest regional AAMR (20.2), and nonmetropolitan areas had higher AAMRs. Conclusion: This study reveals significant demographic disparities in mortality rates related to AMI in malignant older adults. These findings emphasize the need for targeted interventions and improved access to care. |
| format | Article |
| id | doaj-art-c4ea613da61b4086a1953e6ebf0d6dfb |
| institution | DOAJ |
| issn | 2772-4875 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology. Cardiovascular Risk and Prevention |
| spelling | doaj-art-c4ea613da61b4086a1953e6ebf0d6dfb2025-08-20T03:09:44ZengElsevierInternational Journal of Cardiology. Cardiovascular Risk and Prevention2772-48752025-06-012520039210.1016/j.ijcrp.2025.200392Acute myocardial infarction-related mortality among older adults (≥65 years) with malignancy in the U.S. from 1999 to 2020Muhammad Abdullah Naveed0Sivaram Neppala1Himaja Dutt Chigurupati2Ahila Ali3Muhammad Omer Rehan4Ayman Fath5Bazil Azeem6Rabia Iqbal7Manahil Mubeen8Hamza Naveed9Muhammad Naveed Uz Zafar10Mushood Ahmed11Jamal S. Rana12Brijesh Patel13Department of Cardiology, Dow Medical College, Dow University of Health Sciences, Karachi, PakistanDepartment of Cardiology, University of Texas Health Sciences Center, San Antonio, TX, USA; Corresponding author. UT Health Science Center, San Antonio, TX, USA.Department of Internal Medicine, Saint Micheal's Medical Center, Newark, NJ, USADepartment of Cardiology, Dow Medical College, Dow University of Health Sciences, Karachi, PakistanDepartment of Cardiology, Dow Medical College, Dow University of Health Sciences, Karachi, PakistanDepartment of Cardiology, University of Texas Health Sciences Center, San Antonio, TX, USADepartment of Cardiology, Shaheed Mohtarma Benazir Bhutto Medical College Lyari, Karachi, PakistanDepartment of Cardiology, Dow Medical College, Dow University of Health Sciences, Karachi, PakistanDepartment of Cardiology, Dow Medical College, Dow University of Health Sciences, Karachi, PakistanDepartment of Medicine, Queen Elizabeth the Queen Mother Hospital, EKHUFT, Margate, Kent, United KingdomDepartment of Cardiology, Associate Professor at Liaquat University of Medical & Health Sciences, PakistanDepartment of Medicine, Rawalpindi Medical University, Rawalpindi, PakistanDepartment of Cardiology, The Permanente Medical Group, Oakland, CA, USAIndiana University School of Medicine, Indianapolis, IN, USABackground: Acute Myocardial Infarction (AMI) in malignancy is a global threat, causing significant mortality and economic burden. They share common risk factors, highlighting the urgency of addressing this critical issue. Objective: This study analyzed demographic trends and disparities in mortality rates due to AMI in malignancy among adults aged 65 and older from 1999 to 2020. Methods: We used the CDC WONDER database to analyze Age-adjusted mortality rates (AAMRs) for AMI in malignancy patients (ICD-10 I21, C00-C97) from 1999 to 2020, stratifying by sex, race, geography, and metropolitan status. We calculated Average Annual Percentage Changes (AAPCs) and Annual Percentage Changes (APCs) per 100,000 with 95 % confidence intervals (CI) using Joinpoint regression. Results: Between 1999 and 2020, AMI in malignancy accounted for 172,691 deaths among adults aged ≥65 years, with the majority of deaths occurring in medical facilities (56.9 %). The overall AAMR for AMI in malignancy-related deaths decreased from 30.2 in 1999 to 14.2 in 2020, with an AAPC of −3.90 (p < 0.000001). Men showed higher AAMRs than women (28.6 vs. 12.3), with a more pronounced decrease in men (AAPC: 4.22, p < 0.000001) compared to women (AAPC: 3.78, p < 0.000001). Black individuals have the highest AAMR (22.7), followed by Whites (19.3). Arkansas had the highest AAMR (32.3), while Nevada had the lowest (8.1), with the Northeastern region having the highest regional AAMR (20.2), and nonmetropolitan areas had higher AAMRs. Conclusion: This study reveals significant demographic disparities in mortality rates related to AMI in malignant older adults. These findings emphasize the need for targeted interventions and improved access to care.http://www.sciencedirect.com/science/article/pii/S2772487525000303Acute myocardial infarctionMalignancyMortalityRaceGenderGeography |
| spellingShingle | Muhammad Abdullah Naveed Sivaram Neppala Himaja Dutt Chigurupati Ahila Ali Muhammad Omer Rehan Ayman Fath Bazil Azeem Rabia Iqbal Manahil Mubeen Hamza Naveed Muhammad Naveed Uz Zafar Mushood Ahmed Jamal S. Rana Brijesh Patel Acute myocardial infarction-related mortality among older adults (≥65 years) with malignancy in the U.S. from 1999 to 2020 International Journal of Cardiology. Cardiovascular Risk and Prevention Acute myocardial infarction Malignancy Mortality Race Gender Geography |
| title | Acute myocardial infarction-related mortality among older adults (≥65 years) with malignancy in the U.S. from 1999 to 2020 |
| title_full | Acute myocardial infarction-related mortality among older adults (≥65 years) with malignancy in the U.S. from 1999 to 2020 |
| title_fullStr | Acute myocardial infarction-related mortality among older adults (≥65 years) with malignancy in the U.S. from 1999 to 2020 |
| title_full_unstemmed | Acute myocardial infarction-related mortality among older adults (≥65 years) with malignancy in the U.S. from 1999 to 2020 |
| title_short | Acute myocardial infarction-related mortality among older adults (≥65 years) with malignancy in the U.S. from 1999 to 2020 |
| title_sort | acute myocardial infarction related mortality among older adults ≥65 years with malignancy in the u s from 1999 to 2020 |
| topic | Acute myocardial infarction Malignancy Mortality Race Gender Geography |
| url | http://www.sciencedirect.com/science/article/pii/S2772487525000303 |
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