Nutritional and Pharmacological Effects on Oxidative Stress in Soft Tissue and Bone Remodeling

Oxidative damage is the causal link to a multitude of pathologies, such as diabetes, arthritis, neuropathy, heart disease, and asthma. These conditions affect hundreds of millions of people nationwide, and billions worldwide. Even in otherwise healthy individuals, oxidative stress is a natural bypro...

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Main Authors: Benjamin M. Savasky, David P. Mascotti, Naren Patel, Edgardo Rodriguez-Collazo
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:Journal of Nutrition and Metabolism
Online Access:http://dx.doi.org/10.1155/2018/4183407
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author Benjamin M. Savasky
David P. Mascotti
Naren Patel
Edgardo Rodriguez-Collazo
author_facet Benjamin M. Savasky
David P. Mascotti
Naren Patel
Edgardo Rodriguez-Collazo
author_sort Benjamin M. Savasky
collection DOAJ
description Oxidative damage is the causal link to a multitude of pathologies, such as diabetes, arthritis, neuropathy, heart disease, and asthma. These conditions affect hundreds of millions of people nationwide, and billions worldwide. Even in otherwise healthy individuals, oxidative stress is a natural byproduct of metabolism that is augmented in “healthy” activities such as athletics. In many disease states, the pharmacological agents used to treat these conditions can induce oxidative damage and vitamin depletion. It is underappreciated by many that many of the most common medications prescribed result in oxidative stress. Therefore, physicians need to carefully scrutinize which medications their patients are on before surgery and treatment and during the recovery stage to obtain optimal healing results. We provide a review of the current literature of how oxidative damage and inflammation are linked to bone damage, Charcot neuroarthropathy, delayed wound healing, diabetic complications, and delayed flap consolidation. Where available, antioxidant intervention literature is offered to offset these conditions.
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spelling doaj-art-c4e87a9e2c8c4d7c837c5bb8a31fa1142025-02-03T05:54:07ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322018-01-01201810.1155/2018/41834074183407Nutritional and Pharmacological Effects on Oxidative Stress in Soft Tissue and Bone RemodelingBenjamin M. Savasky0David P. Mascotti1Naren Patel2Edgardo Rodriguez-Collazo3University Hospitals, 27100 Chardon Rd., Richmond Heights, OH 4414, USAJohn Carroll University, Department of Chemistry, 1 John Carroll Blvd., University Heights, OH 44118, USAFoot and Ankle Specialists of Ohio, 7482 Center St. Suite #100, Mentor, OH 44060, USASt. Joseph Hospital, Department of Surgery, 875 N. Dearborn St. #400, Chicago, IL 60610, USAOxidative damage is the causal link to a multitude of pathologies, such as diabetes, arthritis, neuropathy, heart disease, and asthma. These conditions affect hundreds of millions of people nationwide, and billions worldwide. Even in otherwise healthy individuals, oxidative stress is a natural byproduct of metabolism that is augmented in “healthy” activities such as athletics. In many disease states, the pharmacological agents used to treat these conditions can induce oxidative damage and vitamin depletion. It is underappreciated by many that many of the most common medications prescribed result in oxidative stress. Therefore, physicians need to carefully scrutinize which medications their patients are on before surgery and treatment and during the recovery stage to obtain optimal healing results. We provide a review of the current literature of how oxidative damage and inflammation are linked to bone damage, Charcot neuroarthropathy, delayed wound healing, diabetic complications, and delayed flap consolidation. Where available, antioxidant intervention literature is offered to offset these conditions.http://dx.doi.org/10.1155/2018/4183407
spellingShingle Benjamin M. Savasky
David P. Mascotti
Naren Patel
Edgardo Rodriguez-Collazo
Nutritional and Pharmacological Effects on Oxidative Stress in Soft Tissue and Bone Remodeling
Journal of Nutrition and Metabolism
title Nutritional and Pharmacological Effects on Oxidative Stress in Soft Tissue and Bone Remodeling
title_full Nutritional and Pharmacological Effects on Oxidative Stress in Soft Tissue and Bone Remodeling
title_fullStr Nutritional and Pharmacological Effects on Oxidative Stress in Soft Tissue and Bone Remodeling
title_full_unstemmed Nutritional and Pharmacological Effects on Oxidative Stress in Soft Tissue and Bone Remodeling
title_short Nutritional and Pharmacological Effects on Oxidative Stress in Soft Tissue and Bone Remodeling
title_sort nutritional and pharmacological effects on oxidative stress in soft tissue and bone remodeling
url http://dx.doi.org/10.1155/2018/4183407
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