Polymorphisms in TP53, MDM2 Genes and Risk of Renal Cell Carcinoma in a Mongolian Population
Objective: Renal cell carcinoma (RCC) is one of the most common malignancies of the kidney, with genetic factors playing a critical role in its development. Among the key genetic factors, TP53 and MDM2 gene polymorphisms have been implicated in cancer susceptibility, but their association with RCC r...
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Mongolian National University of Medical Sciences
2025-03-01
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| Series: | Central Asian Journal of Medical Sciences |
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| Online Access: | https://www.mongoliajol.info/index.php/CAJMS/article/view/4028 |
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| author | Ganbayar Batmunkh Munkhtuya Tumurkhuu Myagmarsuren Purevsuren Bayan-Undur Dagvadorj Yerkyebulan Mukhtar Tsogzolmaa Shiirevnyamba Ganbolor Yura Naranjargal Davaadorj Shiirevnyamba Avirmed |
| author_facet | Ganbayar Batmunkh Munkhtuya Tumurkhuu Myagmarsuren Purevsuren Bayan-Undur Dagvadorj Yerkyebulan Mukhtar Tsogzolmaa Shiirevnyamba Ganbolor Yura Naranjargal Davaadorj Shiirevnyamba Avirmed |
| author_sort | Ganbayar Batmunkh |
| collection | DOAJ |
| description | Objective: Renal cell carcinoma (RCC) is one of the most common malignancies of the kidney, with genetic factors playing a critical role in its development. Among the key genetic factors, TP53 and MDM2 gene polymorphisms have been implicated in cancer susceptibility, but their association with RCC remains unclear in different populations. This study evaluated the association of TP53 and MDM2 gene polymorphisms with RCC risk among Mongolian individuals. Method: In a hospital-based case-control study, 88 RCC cases and 88 matched controls were analyzed for TP53 and MDM2 variants using RFLP-PCR based genotyping. Results: The TP53 CG and CC genotypes and MDM2 TG and GG genotypes were not significantly associated with RCC risk when considered individually. However, individuals carrying the MDM2 GG and TP53 CC genotypes showed elevated RCC risk, although statistical significance was not reached. No strong interaction effects between genotypes and clinical risk factors such as smoking or urinary tract disease were observed. Conclusion: While TP53 and MDM2 polymorphisms showed trends toward association with RCC, larger studies are warranted to clarify their roles in genetic susceptibility within the Mongolian population. |
| format | Article |
| id | doaj-art-c4e6ab1bf3e04f2b949ca5bf1c4fe780 |
| institution | OA Journals |
| issn | 2413-8681 2414-9772 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Mongolian National University of Medical Sciences |
| record_format | Article |
| series | Central Asian Journal of Medical Sciences |
| spelling | doaj-art-c4e6ab1bf3e04f2b949ca5bf1c4fe7802025-08-20T02:23:47ZengMongolian National University of Medical SciencesCentral Asian Journal of Medical Sciences2413-86812414-97722025-03-01111111910.24079/CAJMS.2025.01.0023979Polymorphisms in TP53, MDM2 Genes and Risk of Renal Cell Carcinoma in a Mongolian PopulationGanbayar Batmunkh0https://orcid.org/0000-0001-7228-1102Munkhtuya Tumurkhuu1https://orcid.org/0000-0003-4247-4020Myagmarsuren Purevsuren2https://orcid.org/0009-0000-2937-6587Bayan-Undur Dagvadorj3https://orcid.org/0009-0000-4800-4842Yerkyebulan Mukhtar4https://orcid.org/0000-0002-0912-1517Tsogzolmaa Shiirevnyamba5https://orcid.org/0009-0009-4608-9083Ganbolor Yura6https://orcid.org/0009-0007-3847-2168Naranjargal Davaadorj7https://orcid.org/0009-0009-6227-1539Shiirevnyamba Avirmed8https://orcid.org/0000-0002-1010-8221Department of Health Research, Graduate School, Mongolian National University of Medical Sciences, Ulaanbaatar, MongoliaBrody School of Medicine, East Carolina University, East Carolina, USACenter of Urology and Andrology, The First Central Hospital, Ulaanbaatar, MongoliaCenter of Urology and Andrology, The First Central Hospital, Ulaanbaatar, MongoliaDepartment of Epidemiology and Biostatistics, School of Public Health, Mongolian National University of Medical Sciences, Ulaanbaatar, MongoliaDepartment of Health Research, Graduate School, Mongolian National University of Medical Sciences, Ulaanbaatar, MongoliaDepartment of Health Research, Graduate School, Mongolian National University of Medical Sciences, Ulaanbaatar, MongoliaDepartment of Health Research, Graduate School, Mongolian National University of Medical Sciences, Ulaanbaatar, MongoliaDepartment of Health research, Graduate School, Mongolian National University of Medical Sciences, Ulaanbaatar, MongoliaObjective: Renal cell carcinoma (RCC) is one of the most common malignancies of the kidney, with genetic factors playing a critical role in its development. Among the key genetic factors, TP53 and MDM2 gene polymorphisms have been implicated in cancer susceptibility, but their association with RCC remains unclear in different populations. This study evaluated the association of TP53 and MDM2 gene polymorphisms with RCC risk among Mongolian individuals. Method: In a hospital-based case-control study, 88 RCC cases and 88 matched controls were analyzed for TP53 and MDM2 variants using RFLP-PCR based genotyping. Results: The TP53 CG and CC genotypes and MDM2 TG and GG genotypes were not significantly associated with RCC risk when considered individually. However, individuals carrying the MDM2 GG and TP53 CC genotypes showed elevated RCC risk, although statistical significance was not reached. No strong interaction effects between genotypes and clinical risk factors such as smoking or urinary tract disease were observed. Conclusion: While TP53 and MDM2 polymorphisms showed trends toward association with RCC, larger studies are warranted to clarify their roles in genetic susceptibility within the Mongolian population.https://www.mongoliajol.info/index.php/CAJMS/article/view/4028tp53mdm2renal cell carcinomapolymorphismmongoliacase-control |
| spellingShingle | Ganbayar Batmunkh Munkhtuya Tumurkhuu Myagmarsuren Purevsuren Bayan-Undur Dagvadorj Yerkyebulan Mukhtar Tsogzolmaa Shiirevnyamba Ganbolor Yura Naranjargal Davaadorj Shiirevnyamba Avirmed Polymorphisms in TP53, MDM2 Genes and Risk of Renal Cell Carcinoma in a Mongolian Population Central Asian Journal of Medical Sciences tp53 mdm2 renal cell carcinoma polymorphism mongolia case-control |
| title | Polymorphisms in TP53, MDM2 Genes and Risk of Renal Cell Carcinoma in a Mongolian Population |
| title_full | Polymorphisms in TP53, MDM2 Genes and Risk of Renal Cell Carcinoma in a Mongolian Population |
| title_fullStr | Polymorphisms in TP53, MDM2 Genes and Risk of Renal Cell Carcinoma in a Mongolian Population |
| title_full_unstemmed | Polymorphisms in TP53, MDM2 Genes and Risk of Renal Cell Carcinoma in a Mongolian Population |
| title_short | Polymorphisms in TP53, MDM2 Genes and Risk of Renal Cell Carcinoma in a Mongolian Population |
| title_sort | polymorphisms in tp53 mdm2 genes and risk of renal cell carcinoma in a mongolian population |
| topic | tp53 mdm2 renal cell carcinoma polymorphism mongolia case-control |
| url | https://www.mongoliajol.info/index.php/CAJMS/article/view/4028 |
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