Filtering cells with high mitochondrial content depletes viable metabolically altered malignant cell populations in cancer single-cell studies

Filtering cells with high mitochondrial content depletes viable metabolically altered malignant cell populations in cancer single-cell studies

Abstract Background Single-cell transcriptomics has transformed our understanding of cellular diversity, yet noise from technical artifacts and low-quality cells can obscure key biological signals. A common practice is filtering out cells with a high percentage of mitochondrial RNA counts (pctMT), t...

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Bibliographic Details
Main Authors: Josephine Yates, Agnieszka Kraft, Valentina Boeva
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Genome Biology
Subjects:
MT-RNA
Data quality
Single-cell RNA-seq
Cancer
Drug resistance
Metabolism
Online Access:https://doi.org/10.1186/s13059-025-03559-w
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