Brain injury biomarkers and applications in neurological diseases
Abstract. Neurological diseases are a major health concern, and brain injury is a typical pathological process in various neurological disorders. Different biomarkers in the blood or the cerebrospinal fluid are associated with specific physiological and pathological processes. They are vital in iden...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2025-01-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000003061 |
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| author | Han Zhang Jing Wang Yang Qu Yi Yang Zhen-Ni Guo Yanjie Yin |
| author_facet | Han Zhang Jing Wang Yang Qu Yi Yang Zhen-Ni Guo Yanjie Yin |
| author_sort | Han Zhang |
| collection | DOAJ |
| description | Abstract. Neurological diseases are a major health concern, and brain injury is a typical pathological process in various neurological disorders. Different biomarkers in the blood or the cerebrospinal fluid are associated with specific physiological and pathological processes. They are vital in identifying, diagnosing, and treating brain injuries. In this review, we described biomarkers for neuronal cell body injury (neuron-specific enolase, ubiquitin C-terminal hydrolase-L1, αII-spectrin), axonal injury (neurofilament proteins, tau), astrocyte injury (S100β, glial fibrillary acidic protein), demyelination (myelin basic protein), autoantibodies, and other emerging biomarkers (extracellular vesicles, microRNAs). We aimed to summarize the applications of these biomarkers and their related interests and limits in the diagnosis and prognosis for neurological diseases, including traumatic brain injury, status epilepticus, stroke, Alzheimer’s disease, and infection. In addition, a reasonable outlook for brain injury biomarkers as ideal detection tools for neurological diseases is presented. |
| format | Article |
| id | doaj-art-c4e2b8b6d15f4e29837e72a60a6ca27e |
| institution | Kabale University |
| issn | 0366-6999 2542-5641 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj-art-c4e2b8b6d15f4e29837e72a60a6ca27e2025-01-10T01:10:37ZengWolters KluwerChinese Medical Journal0366-69992542-56412025-01-01138151410.1097/CM9.0000000000003061202501050-00002Brain injury biomarkers and applications in neurological diseasesHan Zhang0Jing Wang1Yang Qu2Yi Yang3Zhen-Ni Guo4Yanjie Yin1 Stroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, Jilin 130021, China1 Stroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, Jilin 130021, China1 Stroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, Jilin 130021, China1 Stroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, Jilin 130021, China1 Stroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, Jilin 130021, ChinaAbstract. Neurological diseases are a major health concern, and brain injury is a typical pathological process in various neurological disorders. Different biomarkers in the blood or the cerebrospinal fluid are associated with specific physiological and pathological processes. They are vital in identifying, diagnosing, and treating brain injuries. In this review, we described biomarkers for neuronal cell body injury (neuron-specific enolase, ubiquitin C-terminal hydrolase-L1, αII-spectrin), axonal injury (neurofilament proteins, tau), astrocyte injury (S100β, glial fibrillary acidic protein), demyelination (myelin basic protein), autoantibodies, and other emerging biomarkers (extracellular vesicles, microRNAs). We aimed to summarize the applications of these biomarkers and their related interests and limits in the diagnosis and prognosis for neurological diseases, including traumatic brain injury, status epilepticus, stroke, Alzheimer’s disease, and infection. In addition, a reasonable outlook for brain injury biomarkers as ideal detection tools for neurological diseases is presented.http://journals.lww.com/10.1097/CM9.0000000000003061 |
| spellingShingle | Han Zhang Jing Wang Yang Qu Yi Yang Zhen-Ni Guo Yanjie Yin Brain injury biomarkers and applications in neurological diseases Chinese Medical Journal |
| title | Brain injury biomarkers and applications in neurological diseases |
| title_full | Brain injury biomarkers and applications in neurological diseases |
| title_fullStr | Brain injury biomarkers and applications in neurological diseases |
| title_full_unstemmed | Brain injury biomarkers and applications in neurological diseases |
| title_short | Brain injury biomarkers and applications in neurological diseases |
| title_sort | brain injury biomarkers and applications in neurological diseases |
| url | http://journals.lww.com/10.1097/CM9.0000000000003061 |
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