Effects of anesthesia and surgery on the expression of Alzheimer’s disease-related proteins in the hippocampus of 5×FAD mice and its sex differences

Effects of anesthesia and surgery on the expression of Alzheimer’s disease-related proteins in the hippocampus of 5×FAD mice and its sex differences

ObjectiveTo investigate the impact of anesthesia and surgery on hippocampal expression of Alzheimer’s disease (AD)-associated proteins in 5×FAD transgenic mice and explore potential sex differences. Methods5×FAD mice were crossbred with C57BL/6J wild-type (WT) mice to generate offspring for genotypi...

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Bibliographic Details
Main Authors: Yinglin ZHANG, Yong HUANG, Li ZHANG, Chao LIANG
Format: Article
Language:English
Published: Shanghai Chinese Clinical Medicine Press Co., Ltd. 2025-06-01
Series:Zhongguo Linchuang Yixue
Subjects:
alzheimer’s disease
anesthesia
surgery
5×fad transgenic mice
sex differences
β-catenin/gsk3β
Online Access:https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20241401
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