Role of a cyclooxygenase-2 cascade in breast cancer cell dissemination
Current therapeutic approaches based on a study of the genetic portrait of a tumor individualize treatment policy to a greater extent, which cre- ates real prospects for the increasing number of patients to recover. Experimental and clinical evidence suggest that the increased expression of the COX-...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2014-07-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/50 |
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| author | M. A. Taipov I. A. Kudryavtsev K. P. Laktionov N. E. Levchenko V. E. Shevchenko |
| author_facet | M. A. Taipov I. A. Kudryavtsev K. P. Laktionov N. E. Levchenko V. E. Shevchenko |
| author_sort | M. A. Taipov |
| collection | DOAJ |
| description | Current therapeutic approaches based on a study of the genetic portrait of a tumor individualize treatment policy to a greater extent, which cre- ates real prospects for the increasing number of patients to recover. Experimental and clinical evidence suggest that the increased expression of the COX-2 gene increases the risk for breast cancer (BC) cell dissemination into distant organs. A number of recent studies have revealed that selec- tive COX-2 inhibitors are able to suppress proliferation, to induce apoptosis in the BC cells, and to inhibit tumor neoangiogenesis. However, this area contains many unclear and disputable problems to be still experimentally solved. Our review deals with the theoretical prerequisites for and the analysis of a role of COX-2 in BC cell dissemination. |
| format | Article |
| id | doaj-art-c4e0f4edff8640d1b8f4db9a0f4f754a |
| institution | Kabale University |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-c4e0f4edff8640d1b8f4db9a0f4f754a2025-08-20T03:37:11ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272014-07-0103-4121710.17650/1994-4098-2013-0-3-4-12-1765Role of a cyclooxygenase-2 cascade in breast cancer cell disseminationM. A. Taipov0I. A. Kudryavtsev1K. P. Laktionov2N. E. Levchenko3V. E. Shevchenko4N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowN.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowCurrent therapeutic approaches based on a study of the genetic portrait of a tumor individualize treatment policy to a greater extent, which cre- ates real prospects for the increasing number of patients to recover. Experimental and clinical evidence suggest that the increased expression of the COX-2 gene increases the risk for breast cancer (BC) cell dissemination into distant organs. A number of recent studies have revealed that selec- tive COX-2 inhibitors are able to suppress proliferation, to induce apoptosis in the BC cells, and to inhibit tumor neoangiogenesis. However, this area contains many unclear and disputable problems to be still experimentally solved. Our review deals with the theoretical prerequisites for and the analysis of a role of COX-2 in BC cell dissemination.https://ojrs.abvpress.ru/ojrs/article/view/50breast cancercox-2cox-1prostaglandinspge2signaling pathwaymarkers for tumor disseminationtargets for goal- oriented therapy |
| spellingShingle | M. A. Taipov I. A. Kudryavtsev K. P. Laktionov N. E. Levchenko V. E. Shevchenko Role of a cyclooxygenase-2 cascade in breast cancer cell dissemination Опухоли женской репродуктивной системы breast cancer cox-2 cox-1 prostaglandins pge2 signaling pathway markers for tumor dissemination targets for goal- oriented therapy |
| title | Role of a cyclooxygenase-2 cascade in breast cancer cell dissemination |
| title_full | Role of a cyclooxygenase-2 cascade in breast cancer cell dissemination |
| title_fullStr | Role of a cyclooxygenase-2 cascade in breast cancer cell dissemination |
| title_full_unstemmed | Role of a cyclooxygenase-2 cascade in breast cancer cell dissemination |
| title_short | Role of a cyclooxygenase-2 cascade in breast cancer cell dissemination |
| title_sort | role of a cyclooxygenase 2 cascade in breast cancer cell dissemination |
| topic | breast cancer cox-2 cox-1 prostaglandins pge2 signaling pathway markers for tumor dissemination targets for goal- oriented therapy |
| url | https://ojrs.abvpress.ru/ojrs/article/view/50 |
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