Total body irradiation versus chemotherapy myeloablative conditioning in B-cell acute lymphoblastic leukaemia patients with first complete remission

Total body irradiation versus chemotherapy myeloablative conditioning in B-cell acute lymphoblastic leukaemia patients with first complete remission

Abstract The best conditioning for hematopoietic stem cell transplantation (HSCT) in acute lymphoblastic leukemia is debated. We analyzed 178 adults undergoing HSCT with total body irradiation (TBI) or chemotherapy conditioning regimens for B-cell leukemia in complete remission 1 (CR1). Both TBI and...

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Bibliographic Details
Main Authors: Mengnan Lv, Yi He, Donglin Yang, Qiaoling Ma, Aiming Pang, Weihua Zhai, Jialin Wei, Xin Chen, Sizhou Feng, Mingzhe Han, Erlie Jiang, Rongli Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Auto-HSCT
Allo-HSCT
Acute lymphoblastic leukemia
Minimal residual disease
Total body irradiation
Online Access:https://doi.org/10.1038/s41598-025-94556-3
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