Effect of Mild Hypothermia after Craniotomy on the Function of Related Organs in Patients with Traumatic Brain Injury
Objective. To investigate the effect of mild hypothermia after craniotomy on the function of related organs in patients with traumatic brain injury. Method. A total of 240 patients with craniocerebral injury from January 2017 to December 2020 were retrospectively analyzed. Patients were randomly div...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Emergency Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2021/4105406 |
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| _version_ | 1841524300330303488 |
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| author | Shu Cai Zheng Lu |
| author_facet | Shu Cai Zheng Lu |
| author_sort | Shu Cai |
| collection | DOAJ |
| description | Objective. To investigate the effect of mild hypothermia after craniotomy on the function of related organs in patients with traumatic brain injury. Method. A total of 240 patients with craniocerebral injury from January 2017 to December 2020 were retrospectively analyzed. Patients were randomly divided into a control group and an experimental group, with 120 cases in each group. The control group was treated with craniotomy decompression, and the experimental group was treated with early mild hypothermia based on craniotomy decompression. Patients’ venous blood was collected before operation (T0), at the end of operation (T1), 24 h after operation (T2), and 2 weeks after operation (T3) to detect the serum levels of the beta-subunit of S100 protein (S100-β); soluble growth stimulation expressed gene 2 (sST2), neutrophil gelatinase-associated lipocalin (NGAL), and interleukin 6 (IL-6). The prognostic effect was evaluated after 2 weeks of treatment. Results. After mild hypothermia treatment after craniotomy and decompression, the patients’ serum S100-β, sST2, NGAL, and IL-6 levels at different time points were significantly lower than the control group, and the total effective rate was higher than that of the control group. Conclusion. The treatment of mild hypothermia after craniotomy can reduce the related organs function damage indicators and inflammatory stress response, thus improving clinical efficacy and prognosis. |
| format | Article |
| id | doaj-art-c4db45a77663437a889e91d7bb86c7bb |
| institution | Kabale University |
| issn | 2090-2840 2090-2859 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Emergency Medicine International |
| spelling | doaj-art-c4db45a77663437a889e91d7bb86c7bb2025-02-03T07:23:28ZengWileyEmergency Medicine International2090-28402090-28592021-01-01202110.1155/2021/41054064105406Effect of Mild Hypothermia after Craniotomy on the Function of Related Organs in Patients with Traumatic Brain InjuryShu Cai0Zheng Lu1Department of Neurosurgery, Affiliated Haian Hospital of Nantong University, Haian 226600, Nantong, Jiangsu, ChinaDepartment of Neurosurgery, Affiliated Haian Hospital of Nantong University, Haian 226600, Nantong, Jiangsu, ChinaObjective. To investigate the effect of mild hypothermia after craniotomy on the function of related organs in patients with traumatic brain injury. Method. A total of 240 patients with craniocerebral injury from January 2017 to December 2020 were retrospectively analyzed. Patients were randomly divided into a control group and an experimental group, with 120 cases in each group. The control group was treated with craniotomy decompression, and the experimental group was treated with early mild hypothermia based on craniotomy decompression. Patients’ venous blood was collected before operation (T0), at the end of operation (T1), 24 h after operation (T2), and 2 weeks after operation (T3) to detect the serum levels of the beta-subunit of S100 protein (S100-β); soluble growth stimulation expressed gene 2 (sST2), neutrophil gelatinase-associated lipocalin (NGAL), and interleukin 6 (IL-6). The prognostic effect was evaluated after 2 weeks of treatment. Results. After mild hypothermia treatment after craniotomy and decompression, the patients’ serum S100-β, sST2, NGAL, and IL-6 levels at different time points were significantly lower than the control group, and the total effective rate was higher than that of the control group. Conclusion. The treatment of mild hypothermia after craniotomy can reduce the related organs function damage indicators and inflammatory stress response, thus improving clinical efficacy and prognosis.http://dx.doi.org/10.1155/2021/4105406 |
| spellingShingle | Shu Cai Zheng Lu Effect of Mild Hypothermia after Craniotomy on the Function of Related Organs in Patients with Traumatic Brain Injury Emergency Medicine International |
| title | Effect of Mild Hypothermia after Craniotomy on the Function of Related Organs in Patients with Traumatic Brain Injury |
| title_full | Effect of Mild Hypothermia after Craniotomy on the Function of Related Organs in Patients with Traumatic Brain Injury |
| title_fullStr | Effect of Mild Hypothermia after Craniotomy on the Function of Related Organs in Patients with Traumatic Brain Injury |
| title_full_unstemmed | Effect of Mild Hypothermia after Craniotomy on the Function of Related Organs in Patients with Traumatic Brain Injury |
| title_short | Effect of Mild Hypothermia after Craniotomy on the Function of Related Organs in Patients with Traumatic Brain Injury |
| title_sort | effect of mild hypothermia after craniotomy on the function of related organs in patients with traumatic brain injury |
| url | http://dx.doi.org/10.1155/2021/4105406 |
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