Prognostic significance of systemic immune inflammation index for ovarian cancer: An updated systematic review and meta-analysis
Abstract Objective Several inflammatory indices have been used to assess the prognosis of ovarian cancer, with variable results. This review assessed whether the systemic immune inflammation index (SII) can predict outcomes in patients with ovarian cancer. Methods Embase, PubMed, CENTRAL, Web of Sci...
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BMC
2025-02-01
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| Series: | Journal of Ovarian Research |
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| Online Access: | https://doi.org/10.1186/s13048-025-01626-1 |
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| author | Boliang Chu Yingying Chen Jiewei Pan |
| author_facet | Boliang Chu Yingying Chen Jiewei Pan |
| author_sort | Boliang Chu |
| collection | DOAJ |
| description | Abstract Objective Several inflammatory indices have been used to assess the prognosis of ovarian cancer, with variable results. This review assessed whether the systemic immune inflammation index (SII) can predict outcomes in patients with ovarian cancer. Methods Embase, PubMed, CENTRAL, Web of Science, and Scopus databases were searched by the two reviewers from inception to 15th October 2024 for studies assessing the relationship between SII and overall survival (OS) or disease-free survival (DFS). Results Ten studies with eleven cohorts were included. Pooled analysis showed that higher SII was a significant predictor of poor OS (HR: 2.35 95% CI: 1.56, 3.55 I2 = 88%) and worse DFS (HR: 2.51 95% CI: 1.71, 3.67 I2 = 80%) after ovarian cancer. Sensitivity analysis failed to change the significance of the results. No publication bias was noted. Most results remained significant on subgroup analyses based on location, sample size, FIGO stage, treatment, adjusted outcomes, cut-off of SII, method of determining cut-off, and quality score. Conclusions SII can be a potential predictor of OS and DFS after ovarian cancer. Further studies are required to improve the evidence. |
| format | Article |
| id | doaj-art-c4d7999337bc4d58baeb2da0142f530c |
| institution | OA Journals |
| issn | 1757-2215 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj-art-c4d7999337bc4d58baeb2da0142f530c2025-08-20T02:16:39ZengBMCJournal of Ovarian Research1757-22152025-02-0118111110.1186/s13048-025-01626-1Prognostic significance of systemic immune inflammation index for ovarian cancer: An updated systematic review and meta-analysisBoliang Chu0Yingying Chen1Jiewei Pan2Department of Gynecology, Huzhou Maternity & Child Health Care HospitalDepartment of Gynecology, Huzhou Maternity & Child Health Care HospitalDepartment of Gynecology, Huzhou Maternity & Child Health Care HospitalAbstract Objective Several inflammatory indices have been used to assess the prognosis of ovarian cancer, with variable results. This review assessed whether the systemic immune inflammation index (SII) can predict outcomes in patients with ovarian cancer. Methods Embase, PubMed, CENTRAL, Web of Science, and Scopus databases were searched by the two reviewers from inception to 15th October 2024 for studies assessing the relationship between SII and overall survival (OS) or disease-free survival (DFS). Results Ten studies with eleven cohorts were included. Pooled analysis showed that higher SII was a significant predictor of poor OS (HR: 2.35 95% CI: 1.56, 3.55 I2 = 88%) and worse DFS (HR: 2.51 95% CI: 1.71, 3.67 I2 = 80%) after ovarian cancer. Sensitivity analysis failed to change the significance of the results. No publication bias was noted. Most results remained significant on subgroup analyses based on location, sample size, FIGO stage, treatment, adjusted outcomes, cut-off of SII, method of determining cut-off, and quality score. Conclusions SII can be a potential predictor of OS and DFS after ovarian cancer. Further studies are required to improve the evidence.https://doi.org/10.1186/s13048-025-01626-1InflammationMarkerRisk factorMalignancyOvarySurvival |
| spellingShingle | Boliang Chu Yingying Chen Jiewei Pan Prognostic significance of systemic immune inflammation index for ovarian cancer: An updated systematic review and meta-analysis Journal of Ovarian Research Inflammation Marker Risk factor Malignancy Ovary Survival |
| title | Prognostic significance of systemic immune inflammation index for ovarian cancer: An updated systematic review and meta-analysis |
| title_full | Prognostic significance of systemic immune inflammation index for ovarian cancer: An updated systematic review and meta-analysis |
| title_fullStr | Prognostic significance of systemic immune inflammation index for ovarian cancer: An updated systematic review and meta-analysis |
| title_full_unstemmed | Prognostic significance of systemic immune inflammation index for ovarian cancer: An updated systematic review and meta-analysis |
| title_short | Prognostic significance of systemic immune inflammation index for ovarian cancer: An updated systematic review and meta-analysis |
| title_sort | prognostic significance of systemic immune inflammation index for ovarian cancer an updated systematic review and meta analysis |
| topic | Inflammation Marker Risk factor Malignancy Ovary Survival |
| url | https://doi.org/10.1186/s13048-025-01626-1 |
| work_keys_str_mv | AT boliangchu prognosticsignificanceofsystemicimmuneinflammationindexforovariancanceranupdatedsystematicreviewandmetaanalysis AT yingyingchen prognosticsignificanceofsystemicimmuneinflammationindexforovariancanceranupdatedsystematicreviewandmetaanalysis AT jieweipan prognosticsignificanceofsystemicimmuneinflammationindexforovariancanceranupdatedsystematicreviewandmetaanalysis |