Radiomics in head and neck squamous cell carcinoma – a leap towards precision oncology
Immunotherapy has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment, with neoadjuvant chemoimmunotherapy showing promising pathological complete response rates (36–42%). Lin et al introduce a radiomics-clinical nomogram using MRI-derived intratumoral and peritumoral features to...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2025-04-01
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| Series: | Journal for ImmunoTherapy of Cancer |
| Online Access: | https://jitc.bmj.com/content/13/4/e011692.full |
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| _version_ | 1849314361328271360 |
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| author | Abhishek Mahajan Pranjal Rai |
| author_facet | Abhishek Mahajan Pranjal Rai |
| author_sort | Abhishek Mahajan |
| collection | DOAJ |
| description | Immunotherapy has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment, with neoadjuvant chemoimmunotherapy showing promising pathological complete response rates (36–42%). Lin et al introduce a radiomics-clinical nomogram using MRI-derived intratumoral and peritumoral features to predict pCR, addressing a critical clinical gap. Their model, emphasizing the peritumoral region (within 3 mm), achieved high predictive accuracy area under curve (AUC) >0.8. While the multicenter design enhances generalizability, standardizing imaging protocols remains a challenge. Integrating radiomics with the Neck Imaging Reporting and Data System could refine post-treatment assessment. This study advances precision oncology in HNSCC, offering a non-invasive tool for personalized treatment strategies. Future directions include artificial intelligence-driven radiomics and radiogenomics to enhance treatment response prediction and patient selection. |
| format | Article |
| id | doaj-art-c4d7446fdfea4e859700c40abee75426 |
| institution | Kabale University |
| issn | 2051-1426 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Journal for ImmunoTherapy of Cancer |
| spelling | doaj-art-c4d7446fdfea4e859700c40abee754262025-08-20T03:52:28ZengBMJ Publishing GroupJournal for ImmunoTherapy of Cancer2051-14262025-04-0113410.1136/jitc-2025-011692Radiomics in head and neck squamous cell carcinoma – a leap towards precision oncologyAbhishek Mahajan0Pranjal Rai1Gastroenterology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, IndiaTata Memorial Hospital, Mumbai, IndiaImmunotherapy has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment, with neoadjuvant chemoimmunotherapy showing promising pathological complete response rates (36–42%). Lin et al introduce a radiomics-clinical nomogram using MRI-derived intratumoral and peritumoral features to predict pCR, addressing a critical clinical gap. Their model, emphasizing the peritumoral region (within 3 mm), achieved high predictive accuracy area under curve (AUC) >0.8. While the multicenter design enhances generalizability, standardizing imaging protocols remains a challenge. Integrating radiomics with the Neck Imaging Reporting and Data System could refine post-treatment assessment. This study advances precision oncology in HNSCC, offering a non-invasive tool for personalized treatment strategies. Future directions include artificial intelligence-driven radiomics and radiogenomics to enhance treatment response prediction and patient selection.https://jitc.bmj.com/content/13/4/e011692.full |
| spellingShingle | Abhishek Mahajan Pranjal Rai Radiomics in head and neck squamous cell carcinoma – a leap towards precision oncology Journal for ImmunoTherapy of Cancer |
| title | Radiomics in head and neck squamous cell carcinoma – a leap towards precision oncology |
| title_full | Radiomics in head and neck squamous cell carcinoma – a leap towards precision oncology |
| title_fullStr | Radiomics in head and neck squamous cell carcinoma – a leap towards precision oncology |
| title_full_unstemmed | Radiomics in head and neck squamous cell carcinoma – a leap towards precision oncology |
| title_short | Radiomics in head and neck squamous cell carcinoma – a leap towards precision oncology |
| title_sort | radiomics in head and neck squamous cell carcinoma a leap towards precision oncology |
| url | https://jitc.bmj.com/content/13/4/e011692.full |
| work_keys_str_mv | AT abhishekmahajan radiomicsinheadandnecksquamouscellcarcinomaaleaptowardsprecisiononcology AT pranjalrai radiomicsinheadandnecksquamouscellcarcinomaaleaptowardsprecisiononcology |