Purification of Crocin-I from Gardenia Yellow by Macroporous Resin Columns In-Series and Its Antidepressant-Like Effect
In this study, the purification of crocin-I from Gardenia yellow by macroporous resin columns in-series was systematically investigated. The in-series macroporous adsorption resins consisting of XAD 4 and XAD 1600N resins were selected on the basis of the evaluation of performance and separation cha...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2022/7651553 |
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| author | Yu Jiang Susu Lin Qiaoqiao Li Yingpeng Tong Ping Wang |
| author_facet | Yu Jiang Susu Lin Qiaoqiao Li Yingpeng Tong Ping Wang |
| author_sort | Yu Jiang |
| collection | DOAJ |
| description | In this study, the purification of crocin-I from Gardenia yellow by macroporous resin columns in-series was systematically investigated. The in-series macroporous adsorption resins consisting of XAD 4 and XAD 1600N resins were selected on the basis of the evaluation of performance and separation characteristics of 17 kinds of resins, including the adsorption capacities, desorption ratio, and separation degree. According to the analysis results, the optimum conditions were as follows: bed volume ratio of XAD 4 and XAD 1600N resins, sample volume, flow rate, and methanol concentration were 3 : 1, 5 BV, 15 BV/h, and 70%, respectively (BV was the bed volume of XAD 4 resin). After one run treatment, the separation degree of crocin-I at 254 nm and 440 nm decreased from 1.92 to 0.08 (DC−254 nm) and from 0.71 to 0.36 (DC−440 nm), respectively. The results showed that the in-series macroporous resins revealed a high capacity in the purification of crocin-I. Meanwhile, in the animal experiment, the forced swimming tests were regulated by crocin-I and Gardenia yellow, which demonstrated that crocin-I was the main constituent of Gardenia yellow and had potential antidepressant biological activities. |
| format | Article |
| id | doaj-art-c4d40303d3d047289807e45180cf347f |
| institution | OA Journals |
| issn | 2090-9071 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-c4d40303d3d047289807e45180cf347f2025-08-20T02:18:47ZengWileyJournal of Chemistry2090-90712022-01-01202210.1155/2022/7651553Purification of Crocin-I from Gardenia Yellow by Macroporous Resin Columns In-Series and Its Antidepressant-Like EffectYu Jiang0Susu Lin1Qiaoqiao Li2Yingpeng Tong3Ping Wang4College of Pharmaceutical SciencesCollege of Pharmaceutical SciencesCollege of Pharmaceutical SciencesInstitute of Natural Medicine and Health ProductCollege of Pharmaceutical SciencesIn this study, the purification of crocin-I from Gardenia yellow by macroporous resin columns in-series was systematically investigated. The in-series macroporous adsorption resins consisting of XAD 4 and XAD 1600N resins were selected on the basis of the evaluation of performance and separation characteristics of 17 kinds of resins, including the adsorption capacities, desorption ratio, and separation degree. According to the analysis results, the optimum conditions were as follows: bed volume ratio of XAD 4 and XAD 1600N resins, sample volume, flow rate, and methanol concentration were 3 : 1, 5 BV, 15 BV/h, and 70%, respectively (BV was the bed volume of XAD 4 resin). After one run treatment, the separation degree of crocin-I at 254 nm and 440 nm decreased from 1.92 to 0.08 (DC−254 nm) and from 0.71 to 0.36 (DC−440 nm), respectively. The results showed that the in-series macroporous resins revealed a high capacity in the purification of crocin-I. Meanwhile, in the animal experiment, the forced swimming tests were regulated by crocin-I and Gardenia yellow, which demonstrated that crocin-I was the main constituent of Gardenia yellow and had potential antidepressant biological activities.http://dx.doi.org/10.1155/2022/7651553 |
| spellingShingle | Yu Jiang Susu Lin Qiaoqiao Li Yingpeng Tong Ping Wang Purification of Crocin-I from Gardenia Yellow by Macroporous Resin Columns In-Series and Its Antidepressant-Like Effect Journal of Chemistry |
| title | Purification of Crocin-I from Gardenia Yellow by Macroporous Resin Columns In-Series and Its Antidepressant-Like Effect |
| title_full | Purification of Crocin-I from Gardenia Yellow by Macroporous Resin Columns In-Series and Its Antidepressant-Like Effect |
| title_fullStr | Purification of Crocin-I from Gardenia Yellow by Macroporous Resin Columns In-Series and Its Antidepressant-Like Effect |
| title_full_unstemmed | Purification of Crocin-I from Gardenia Yellow by Macroporous Resin Columns In-Series and Its Antidepressant-Like Effect |
| title_short | Purification of Crocin-I from Gardenia Yellow by Macroporous Resin Columns In-Series and Its Antidepressant-Like Effect |
| title_sort | purification of crocin i from gardenia yellow by macroporous resin columns in series and its antidepressant like effect |
| url | http://dx.doi.org/10.1155/2022/7651553 |
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