Rationally designed biomimetic bone scaffolds with hierarchical porous-architecture: Microstructure and mechanical performance
A biomimetic strategy was adopted by incorporating nano-fluorcanasite (nFC) within biocompatible and biodegradable poly-(ε-caprolactone) (PCL) matrix to obtain functionally tuned bio-nanocomposite bone scaffolds. A hybrid approach was adopted using fused deposition modelling, solvent casting and the...
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| Format: | Article |
| Language: | English |
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Budapest University of Technology and Economics
2023-06-01
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| Series: | eXPRESS Polymer Letters |
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| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0012371&mi=cd |
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| author | Vijay Shankar Kumawat Sanchita Bandyopadhyay-Ghosh Subrata Bandhu Ghosh |
| author_facet | Vijay Shankar Kumawat Sanchita Bandyopadhyay-Ghosh Subrata Bandhu Ghosh |
| author_sort | Vijay Shankar Kumawat |
| collection | DOAJ |
| description | A biomimetic strategy was adopted by incorporating nano-fluorcanasite (nFC) within biocompatible and biodegradable poly-(ε-caprolactone) (PCL) matrix to obtain functionally tuned bio-nanocomposite bone scaffolds. A hybrid approach was adopted using fused deposition modelling, solvent casting and thermally induced phase separation to develop the scaffolds. Phase evolution study through X-ray diffraction revealed dominant crystalline phases (fluorcanasite and fluorapatite) and enhanced crystallinity of the scaffolds. Microstructural investigation through field emission-scanning electron microscopy revealed interconnected gradient porosities and hierarchical (meso, micro and macro) porous architecture within the scaffolds similar to natural bone. The elemental mapping study further confirmed higher calcium:phosphate (Ca:P) ratio upon nFC incorporation, desirable for bone repair. The volume visualisation through X-ray micro-computed tomography confirmed the presence of porous micro-architecture and homogenous dispersion of nFC particulates within the scaffolds. Mechanical performance of the bio-nanocomposite scaffolds was also found to be enhanced to sustain the load against pore collapse. Enhanced cell viability and cellular proliferation response with human osteosarcoma bone cells established the in-vitro biocompatibility of the scaffolds. Finally, this study opens up a unique pathway in the fabrication of biomimetic bone scaffolds with a highly conducive cellular environment. |
| format | Article |
| id | doaj-art-c4cbc2795fa940918d46f38b364d5326 |
| institution | Kabale University |
| issn | 1788-618X |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Budapest University of Technology and Economics |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj-art-c4cbc2795fa940918d46f38b364d53262025-08-20T03:58:54ZengBudapest University of Technology and EconomicseXPRESS Polymer Letters1788-618X2023-06-0117661062410.3144/expresspolymlett.2023.45Rationally designed biomimetic bone scaffolds with hierarchical porous-architecture: Microstructure and mechanical performanceVijay Shankar KumawatSanchita Bandyopadhyay-GhoshSubrata Bandhu GhoshA biomimetic strategy was adopted by incorporating nano-fluorcanasite (nFC) within biocompatible and biodegradable poly-(ε-caprolactone) (PCL) matrix to obtain functionally tuned bio-nanocomposite bone scaffolds. A hybrid approach was adopted using fused deposition modelling, solvent casting and thermally induced phase separation to develop the scaffolds. Phase evolution study through X-ray diffraction revealed dominant crystalline phases (fluorcanasite and fluorapatite) and enhanced crystallinity of the scaffolds. Microstructural investigation through field emission-scanning electron microscopy revealed interconnected gradient porosities and hierarchical (meso, micro and macro) porous architecture within the scaffolds similar to natural bone. The elemental mapping study further confirmed higher calcium:phosphate (Ca:P) ratio upon nFC incorporation, desirable for bone repair. The volume visualisation through X-ray micro-computed tomography confirmed the presence of porous micro-architecture and homogenous dispersion of nFC particulates within the scaffolds. Mechanical performance of the bio-nanocomposite scaffolds was also found to be enhanced to sustain the load against pore collapse. Enhanced cell viability and cellular proliferation response with human osteosarcoma bone cells established the in-vitro biocompatibility of the scaffolds. Finally, this study opens up a unique pathway in the fabrication of biomimetic bone scaffolds with a highly conducive cellular environment.http://www.expresspolymlett.com/letolt.php?file=EPL-0012371&mi=cdbiopolymers, biocompositesbone scaffoldbiomimeticadditive manufacturingbone tissue engineering |
| spellingShingle | Vijay Shankar Kumawat Sanchita Bandyopadhyay-Ghosh Subrata Bandhu Ghosh Rationally designed biomimetic bone scaffolds with hierarchical porous-architecture: Microstructure and mechanical performance eXPRESS Polymer Letters biopolymers, biocomposites bone scaffold biomimetic additive manufacturing bone tissue engineering |
| title | Rationally designed biomimetic bone scaffolds with hierarchical porous-architecture: Microstructure and mechanical performance |
| title_full | Rationally designed biomimetic bone scaffolds with hierarchical porous-architecture: Microstructure and mechanical performance |
| title_fullStr | Rationally designed biomimetic bone scaffolds with hierarchical porous-architecture: Microstructure and mechanical performance |
| title_full_unstemmed | Rationally designed biomimetic bone scaffolds with hierarchical porous-architecture: Microstructure and mechanical performance |
| title_short | Rationally designed biomimetic bone scaffolds with hierarchical porous-architecture: Microstructure and mechanical performance |
| title_sort | rationally designed biomimetic bone scaffolds with hierarchical porous architecture microstructure and mechanical performance |
| topic | biopolymers, biocomposites bone scaffold biomimetic additive manufacturing bone tissue engineering |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0012371&mi=cd |
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