Diagnostic performance of echocardiography for the detection of acute cardiac allograft rejection: a systematic review and meta-analysis.
<h4>Objective</h4>Many studies have addressed the diagnostic performance of echocardiography to evaluate acute cardiac allograft rejection compared with endomyocardial biopsy. But the existence of heterogeneity limited its clinical application. Thus, we conducted a comprehensive, systema...
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| Format: | Article |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0121228 |
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| _version_ | 1849320773344296960 |
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| author | Wei Lu Jun Zheng Xudong Pan Lizhong Sun |
| author_facet | Wei Lu Jun Zheng Xudong Pan Lizhong Sun |
| author_sort | Wei Lu |
| collection | DOAJ |
| description | <h4>Objective</h4>Many studies have addressed the diagnostic performance of echocardiography to evaluate acute cardiac allograft rejection compared with endomyocardial biopsy. But the existence of heterogeneity limited its clinical application. Thus, we conducted a comprehensive, systematic literature review and meta-analysis for the purpose.<h4>Methods</h4>Studies prior to September 1, 2014 identified by Medline/PubMed, EMBASE and Cochrance were examined by two independent reviews. We conducted meta-analysis by using Meta-DiSc 1.4 software. An assessment tool of QUADAS-2 was applied to evaluate the risk of bias and applicability of the studies.<h4>Results</h4>Thirty studies met the inclusion criteria of meta-analysis. The four parameters of pressure half time, isovolumic relaxation time, index of myocardial performance and late diastolic mitral annular motion velocity were included in the meta-analysis, with a pooled diagnostic odds ratio of 10.43, 6.89, 15.95 and 5.68 respectively, and the area under the summary receiver operating characteristic curves value of 0.829, 0.599, 0.871 and 0.685 respectively.<h4>Conclusion</h4>The meta-analysis and systematic review demonstrate that no single parameter of echocardiography showed a reliable diagnostic performance for acute cardiac allograft rejection. A result of echocardiography for ACAR should be comprehensively considered by physicians in the context of clinical presentations and imaging feature. |
| format | Article |
| id | doaj-art-c4cb9670ea5f4b808b81e5a40b248022 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-c4cb9670ea5f4b808b81e5a40b2480222025-08-20T03:49:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01103e012122810.1371/journal.pone.0121228Diagnostic performance of echocardiography for the detection of acute cardiac allograft rejection: a systematic review and meta-analysis.Wei LuJun ZhengXudong PanLizhong Sun<h4>Objective</h4>Many studies have addressed the diagnostic performance of echocardiography to evaluate acute cardiac allograft rejection compared with endomyocardial biopsy. But the existence of heterogeneity limited its clinical application. Thus, we conducted a comprehensive, systematic literature review and meta-analysis for the purpose.<h4>Methods</h4>Studies prior to September 1, 2014 identified by Medline/PubMed, EMBASE and Cochrance were examined by two independent reviews. We conducted meta-analysis by using Meta-DiSc 1.4 software. An assessment tool of QUADAS-2 was applied to evaluate the risk of bias and applicability of the studies.<h4>Results</h4>Thirty studies met the inclusion criteria of meta-analysis. The four parameters of pressure half time, isovolumic relaxation time, index of myocardial performance and late diastolic mitral annular motion velocity were included in the meta-analysis, with a pooled diagnostic odds ratio of 10.43, 6.89, 15.95 and 5.68 respectively, and the area under the summary receiver operating characteristic curves value of 0.829, 0.599, 0.871 and 0.685 respectively.<h4>Conclusion</h4>The meta-analysis and systematic review demonstrate that no single parameter of echocardiography showed a reliable diagnostic performance for acute cardiac allograft rejection. A result of echocardiography for ACAR should be comprehensively considered by physicians in the context of clinical presentations and imaging feature.https://doi.org/10.1371/journal.pone.0121228 |
| spellingShingle | Wei Lu Jun Zheng Xudong Pan Lizhong Sun Diagnostic performance of echocardiography for the detection of acute cardiac allograft rejection: a systematic review and meta-analysis. PLoS ONE |
| title | Diagnostic performance of echocardiography for the detection of acute cardiac allograft rejection: a systematic review and meta-analysis. |
| title_full | Diagnostic performance of echocardiography for the detection of acute cardiac allograft rejection: a systematic review and meta-analysis. |
| title_fullStr | Diagnostic performance of echocardiography for the detection of acute cardiac allograft rejection: a systematic review and meta-analysis. |
| title_full_unstemmed | Diagnostic performance of echocardiography for the detection of acute cardiac allograft rejection: a systematic review and meta-analysis. |
| title_short | Diagnostic performance of echocardiography for the detection of acute cardiac allograft rejection: a systematic review and meta-analysis. |
| title_sort | diagnostic performance of echocardiography for the detection of acute cardiac allograft rejection a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0121228 |
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