Extracellular vesicles for delivering therapeutic agents in ischemia/reperfusion injury
Ischemia/reperfusion (I/R) injury is marked by the restriction and subsequent restoration of blood supply to an organ. This process can exacerbate the initial tissue damage, leading to further disorders, disability, and even death. Extracellular vesicles (EVs) are crucial in cell communication by re...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087624000825 |
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| author | Weihang Zhou Xinchi Jiang Jianqing Gao |
| author_facet | Weihang Zhou Xinchi Jiang Jianqing Gao |
| author_sort | Weihang Zhou |
| collection | DOAJ |
| description | Ischemia/reperfusion (I/R) injury is marked by the restriction and subsequent restoration of blood supply to an organ. This process can exacerbate the initial tissue damage, leading to further disorders, disability, and even death. Extracellular vesicles (EVs) are crucial in cell communication by releasing cargo that regulates the physiological state of recipient cells. The development of EVs presents a novel avenue for delivering therapeutic agents in I/R therapy. The therapeutic potential of EVs derived from stem cells, endothelial cells, and plasma in I/R injury has been actively investigated. Therefore, this review aims to provide an overview of the pathological process of I/R injury and the biophysical properties of EVs. We noted that EVs serve as nontoxic, flexible, and multifunctional carriers for delivering therapeutic agents capable of intervening in I/R injury progression. The therapeutic efficacy of EVs can be enhanced through various engineering strategies. Improving the tropism of EVs via surface modification and modulating their contents via preconditioning are widely investigated in preclinical studies. Finally, we summarize the challenges in the production and delivery of EV-based therapy in I/R injury and discuss how it can advance. This review will encourage further exploration in developing efficient EV-based delivery systems for I/R treatment. |
| format | Article |
| id | doaj-art-c4c98e4e34c4445cab2d1f9ed0ce1307 |
| institution | Kabale University |
| issn | 1818-0876 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj-art-c4c98e4e34c4445cab2d1f9ed0ce13072024-12-25T04:21:00ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762024-12-01196100965Extracellular vesicles for delivering therapeutic agents in ischemia/reperfusion injuryWeihang Zhou0Xinchi Jiang1Jianqing Gao2State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, ChinaState Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Corresponding authors.State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Department of Pharmacy, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Corresponding authors.Ischemia/reperfusion (I/R) injury is marked by the restriction and subsequent restoration of blood supply to an organ. This process can exacerbate the initial tissue damage, leading to further disorders, disability, and even death. Extracellular vesicles (EVs) are crucial in cell communication by releasing cargo that regulates the physiological state of recipient cells. The development of EVs presents a novel avenue for delivering therapeutic agents in I/R therapy. The therapeutic potential of EVs derived from stem cells, endothelial cells, and plasma in I/R injury has been actively investigated. Therefore, this review aims to provide an overview of the pathological process of I/R injury and the biophysical properties of EVs. We noted that EVs serve as nontoxic, flexible, and multifunctional carriers for delivering therapeutic agents capable of intervening in I/R injury progression. The therapeutic efficacy of EVs can be enhanced through various engineering strategies. Improving the tropism of EVs via surface modification and modulating their contents via preconditioning are widely investigated in preclinical studies. Finally, we summarize the challenges in the production and delivery of EV-based therapy in I/R injury and discuss how it can advance. This review will encourage further exploration in developing efficient EV-based delivery systems for I/R treatment.http://www.sciencedirect.com/science/article/pii/S1818087624000825Extracellular vesiclesExtracellular vesicle engineeringIschemia/reperfusion injuryNanocarrierDrug delivery |
| spellingShingle | Weihang Zhou Xinchi Jiang Jianqing Gao Extracellular vesicles for delivering therapeutic agents in ischemia/reperfusion injury Asian Journal of Pharmaceutical Sciences Extracellular vesicles Extracellular vesicle engineering Ischemia/reperfusion injury Nanocarrier Drug delivery |
| title | Extracellular vesicles for delivering therapeutic agents in ischemia/reperfusion injury |
| title_full | Extracellular vesicles for delivering therapeutic agents in ischemia/reperfusion injury |
| title_fullStr | Extracellular vesicles for delivering therapeutic agents in ischemia/reperfusion injury |
| title_full_unstemmed | Extracellular vesicles for delivering therapeutic agents in ischemia/reperfusion injury |
| title_short | Extracellular vesicles for delivering therapeutic agents in ischemia/reperfusion injury |
| title_sort | extracellular vesicles for delivering therapeutic agents in ischemia reperfusion injury |
| topic | Extracellular vesicles Extracellular vesicle engineering Ischemia/reperfusion injury Nanocarrier Drug delivery |
| url | http://www.sciencedirect.com/science/article/pii/S1818087624000825 |
| work_keys_str_mv | AT weihangzhou extracellularvesiclesfordeliveringtherapeuticagentsinischemiareperfusioninjury AT xinchijiang extracellularvesiclesfordeliveringtherapeuticagentsinischemiareperfusioninjury AT jianqinggao extracellularvesiclesfordeliveringtherapeuticagentsinischemiareperfusioninjury |