Fish Oil in the Treatment of Ulcerative Colitis
Patients with active ulcerative colitis have increased levels of leukotriene B4 in their rectal mucosa. Eicosapentaenoic acid (EPA) competitively inhibits the cyclo-oxgenase pathway and reduces the formation of cyclo-oxygenase pathway products. EPA is a good substrate for lipoxygenase enzymes and is...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1990-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1990/586593 |
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| _version_ | 1832545671639465984 |
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| author | C Ó'Moráin A Tobin T McColl Y Suzuki |
| author_facet | C Ó'Moráin A Tobin T McColl Y Suzuki |
| author_sort | C Ó'Moráin |
| collection | DOAJ |
| description | Patients with active ulcerative colitis have increased levels of
leukotriene B4 in their rectal mucosa. Eicosapentaenoic acid (EPA) competitively
inhibits the cyclo-oxgenase pathway and reduces the formation of cyclo-oxygenase
pathway products. EPA is a good substrate for lipoxygenase enzymes
and is efficiently converted to leukotriene 85, which is less biologically active.
The conversion of EPA to leukotriene B5 is as efficient as that of arachidonic
acid to teukotriene B4. Two pilot studies showed benefit of EPA in the treatment
of ulcerative colitis. Two of three controlled studies suggest that EPA is more
effective than placebo in the treatment of active chronic ulcerative colitis. The
mechanism of action is probably reduction of leukotriene B4, but EPA could
increase cell and lysosomal membrane stability, or it may exert its effect by
reducing interleukin-l. More controlled studies and detailed investigation into
the mode of action of EPA are required. |
| format | Article |
| id | doaj-art-c4c97acf483248759a664d5d10f13988 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1990-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-c4c97acf483248759a664d5d10f139882025-02-03T07:25:11ZengWileyCanadian Journal of Gastroenterology0835-79001990-01-014742042310.1155/1990/586593Fish Oil in the Treatment of Ulcerative ColitisC Ó'MoráinA TobinT McCollY SuzukiPatients with active ulcerative colitis have increased levels of leukotriene B4 in their rectal mucosa. Eicosapentaenoic acid (EPA) competitively inhibits the cyclo-oxgenase pathway and reduces the formation of cyclo-oxygenase pathway products. EPA is a good substrate for lipoxygenase enzymes and is efficiently converted to leukotriene 85, which is less biologically active. The conversion of EPA to leukotriene B5 is as efficient as that of arachidonic acid to teukotriene B4. Two pilot studies showed benefit of EPA in the treatment of ulcerative colitis. Two of three controlled studies suggest that EPA is more effective than placebo in the treatment of active chronic ulcerative colitis. The mechanism of action is probably reduction of leukotriene B4, but EPA could increase cell and lysosomal membrane stability, or it may exert its effect by reducing interleukin-l. More controlled studies and detailed investigation into the mode of action of EPA are required.http://dx.doi.org/10.1155/1990/586593 |
| spellingShingle | C Ó'Moráin A Tobin T McColl Y Suzuki Fish Oil in the Treatment of Ulcerative Colitis Canadian Journal of Gastroenterology |
| title | Fish Oil in the Treatment of Ulcerative Colitis |
| title_full | Fish Oil in the Treatment of Ulcerative Colitis |
| title_fullStr | Fish Oil in the Treatment of Ulcerative Colitis |
| title_full_unstemmed | Fish Oil in the Treatment of Ulcerative Colitis |
| title_short | Fish Oil in the Treatment of Ulcerative Colitis |
| title_sort | fish oil in the treatment of ulcerative colitis |
| url | http://dx.doi.org/10.1155/1990/586593 |
| work_keys_str_mv | AT comorain fishoilinthetreatmentofulcerativecolitis AT atobin fishoilinthetreatmentofulcerativecolitis AT tmccoll fishoilinthetreatmentofulcerativecolitis AT ysuzuki fishoilinthetreatmentofulcerativecolitis |