The role of radiotherapy in small cell lung cancer: a new paradigm for the radiation oncologist
Small cell lung cancer (SCLC) is an aggressive tumor that presents in most cases as a metastatic disease. The prognosis is poor, but the advent of immunotherapy has rekindled hopes for outcomes. Radiotherapy plays a crucial role in this oncological scenario, and there are still many open questions o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1541527/full |
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| author | Paolo Borghetti Sara Ramella Sara Ramella Umberto Ricardi |
| author_facet | Paolo Borghetti Sara Ramella Sara Ramella Umberto Ricardi |
| author_sort | Paolo Borghetti |
| collection | DOAJ |
| description | Small cell lung cancer (SCLC) is an aggressive tumor that presents in most cases as a metastatic disease. The prognosis is poor, but the advent of immunotherapy has rekindled hopes for outcomes. Radiotherapy plays a crucial role in this oncological scenario, and there are still many open questions on the correct application of radiotherapy and its integration with chemotherapy and immunotherapy. These issues are of great interest to the oncology community; among these, in particular, there are the choice of optimal fractionation and total dose for thoracic radiotherapy in limited SCLC and its biological implications, the role of prophylactic cranial irradiation and thoracic consolidation in the context of modern treatments with chemoimmunotherapy in extensive SCLC, the role and indications of stereotactic radiotherapy in oligometastatic scenario and finally the complex clinical and multidisciplinary management of SCLC. This perspective article aims to describe the strengths and limitations of the role of radiotherapy in SCLC, highlighting the critical role of radiotherapy and the radiation oncologist, with the need to implement specific knowledge and skills on SCLC. |
| format | Article |
| id | doaj-art-c4c868e532994a9599a0393613ccb48b |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-c4c868e532994a9599a0393613ccb48b2025-01-24T05:21:23ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.15415271541527The role of radiotherapy in small cell lung cancer: a new paradigm for the radiation oncologistPaolo Borghetti0Sara Ramella1Sara Ramella2Umberto Ricardi3Radiation Oncology Department, Azienda Socio Sanitaria Territoriale Spedali Civili and University of Brescia, Brescia, ItalyResearch Unit of Radiation Oncology Unit, Department of Medicine and Surgery, Università Campus Bio-Medico, Rome, ItalyRadiation Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, ItalyDepartment of Oncology, University of Turin, Turin, ItalySmall cell lung cancer (SCLC) is an aggressive tumor that presents in most cases as a metastatic disease. The prognosis is poor, but the advent of immunotherapy has rekindled hopes for outcomes. Radiotherapy plays a crucial role in this oncological scenario, and there are still many open questions on the correct application of radiotherapy and its integration with chemotherapy and immunotherapy. These issues are of great interest to the oncology community; among these, in particular, there are the choice of optimal fractionation and total dose for thoracic radiotherapy in limited SCLC and its biological implications, the role of prophylactic cranial irradiation and thoracic consolidation in the context of modern treatments with chemoimmunotherapy in extensive SCLC, the role and indications of stereotactic radiotherapy in oligometastatic scenario and finally the complex clinical and multidisciplinary management of SCLC. This perspective article aims to describe the strengths and limitations of the role of radiotherapy in SCLC, highlighting the critical role of radiotherapy and the radiation oncologist, with the need to implement specific knowledge and skills on SCLC.https://www.frontiersin.org/articles/10.3389/fonc.2024.1541527/fullsmall cell lung cancerradiotherapyimmunotherapymultidisciplinary teamradiation oncologist |
| spellingShingle | Paolo Borghetti Sara Ramella Sara Ramella Umberto Ricardi The role of radiotherapy in small cell lung cancer: a new paradigm for the radiation oncologist Frontiers in Oncology small cell lung cancer radiotherapy immunotherapy multidisciplinary team radiation oncologist |
| title | The role of radiotherapy in small cell lung cancer: a new paradigm for the radiation oncologist |
| title_full | The role of radiotherapy in small cell lung cancer: a new paradigm for the radiation oncologist |
| title_fullStr | The role of radiotherapy in small cell lung cancer: a new paradigm for the radiation oncologist |
| title_full_unstemmed | The role of radiotherapy in small cell lung cancer: a new paradigm for the radiation oncologist |
| title_short | The role of radiotherapy in small cell lung cancer: a new paradigm for the radiation oncologist |
| title_sort | role of radiotherapy in small cell lung cancer a new paradigm for the radiation oncologist |
| topic | small cell lung cancer radiotherapy immunotherapy multidisciplinary team radiation oncologist |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1541527/full |
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