Caplacizumab in the Treatment of Patients with Recurrent Thrombotic Thrombocytopenic Purpura (TTP)
We report two cases of recurrent thrombotic thrombocytopenic purpura, both patients without significant personal pathological antecedents, in which the evolution was favorable following the association of Caplacizumab with the classic treatment with plasmapheresis and cortisone therapy. We studied t...
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| Language: | English |
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Romanian Society of Hematology
2025-03-01
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| Series: | Documenta Haematologica |
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| Online Access: | https://www.dhrrh.ro/wp-content/uploads/2025/03/DHRRH-2025-1-art6.pdf |
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| author | Mihaela-Sabrina HERDEA Adela-Sara IONESCU Oana PATRINOIU Mihaela ANDREESCU |
| author_facet | Mihaela-Sabrina HERDEA Adela-Sara IONESCU Oana PATRINOIU Mihaela ANDREESCU |
| author_sort | Mihaela-Sabrina HERDEA |
| collection | DOAJ |
| description | We report two cases of recurrent thrombotic thrombocytopenic purpura, both patients without significant personal pathological antecedents, in which the evolution was favorable following the association of Caplacizumab with the classic treatment with plasmapheresis and cortisone therapy. We studied two cases of thrombotic thrombocytopenic purpura in two young women, without comorbidities or background treatment, who relapsed after the initial treatment with corticotherapy and plasma exchange, after a period of 4 and 6 years with a different clinical picture, compared to the initial one. The difference is given by the presence/absence of neurological manifestations, both at the first presentation and at the relapse of the disease. In both exposed cases, following the association of Caplacizumab with the classic PTT treatment represented by plasmapheresis and cortisone therapy, the patients had a favorable response to therapy and a maintenance of remission at 1,3 and 2+ years after the relapse.
In conclusion, the treatment of relapsed thrombotic thrombocytopenic purpura with a humanized monoclonal antibody targeting von Willebrand factor, combined with plasma exchange and corticosteroids, enhances the treatment of this pathology and the remission. |
| format | Article |
| id | doaj-art-c4c7b41e8d26403eaf97857bd32b07ca |
| institution | OA Journals |
| issn | 3008-220X 2972-242X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Romanian Society of Hematology |
| record_format | Article |
| series | Documenta Haematologica |
| spelling | doaj-art-c4c7b41e8d26403eaf97857bd32b07ca2025-08-20T02:19:37ZengRomanian Society of HematologyDocumenta Haematologica3008-220X2972-242X2025-03-0131495410.59854/dhrrh.2025.3.1.49Caplacizumab in the Treatment of Patients with Recurrent Thrombotic Thrombocytopenic Purpura (TTP)Mihaela-Sabrina HERDEA0Adela-Sara IONESCU1Oana PATRINOIU2Mihaela ANDREESCU3https://orcid.org/0000-0003-0532-7929"Colentina" Clinical Hospital, Bucharest, Romania"Colentina" Clinical Hospital, Bucharest, Romania"Colentina" Clinical Hospital, Bucharest, Romania"Titu Maiorescu" University of Medicine and Pharmacy, Bucharest, RomaniaWe report two cases of recurrent thrombotic thrombocytopenic purpura, both patients without significant personal pathological antecedents, in which the evolution was favorable following the association of Caplacizumab with the classic treatment with plasmapheresis and cortisone therapy. We studied two cases of thrombotic thrombocytopenic purpura in two young women, without comorbidities or background treatment, who relapsed after the initial treatment with corticotherapy and plasma exchange, after a period of 4 and 6 years with a different clinical picture, compared to the initial one. The difference is given by the presence/absence of neurological manifestations, both at the first presentation and at the relapse of the disease. In both exposed cases, following the association of Caplacizumab with the classic PTT treatment represented by plasmapheresis and cortisone therapy, the patients had a favorable response to therapy and a maintenance of remission at 1,3 and 2+ years after the relapse. In conclusion, the treatment of relapsed thrombotic thrombocytopenic purpura with a humanized monoclonal antibody targeting von Willebrand factor, combined with plasma exchange and corticosteroids, enhances the treatment of this pathology and the remission.https://www.dhrrh.ro/wp-content/uploads/2025/03/DHRRH-2025-1-art6.pdfthrombotic thrombocytopenic purpuracaplacizumabplateletsadamts 13 |
| spellingShingle | Mihaela-Sabrina HERDEA Adela-Sara IONESCU Oana PATRINOIU Mihaela ANDREESCU Caplacizumab in the Treatment of Patients with Recurrent Thrombotic Thrombocytopenic Purpura (TTP) Documenta Haematologica thrombotic thrombocytopenic purpura caplacizumab platelets adamts 13 |
| title | Caplacizumab in the Treatment of Patients with Recurrent Thrombotic Thrombocytopenic Purpura (TTP) |
| title_full | Caplacizumab in the Treatment of Patients with Recurrent Thrombotic Thrombocytopenic Purpura (TTP) |
| title_fullStr | Caplacizumab in the Treatment of Patients with Recurrent Thrombotic Thrombocytopenic Purpura (TTP) |
| title_full_unstemmed | Caplacizumab in the Treatment of Patients with Recurrent Thrombotic Thrombocytopenic Purpura (TTP) |
| title_short | Caplacizumab in the Treatment of Patients with Recurrent Thrombotic Thrombocytopenic Purpura (TTP) |
| title_sort | caplacizumab in the treatment of patients with recurrent thrombotic thrombocytopenic purpura ttp |
| topic | thrombotic thrombocytopenic purpura caplacizumab platelets adamts 13 |
| url | https://www.dhrrh.ro/wp-content/uploads/2025/03/DHRRH-2025-1-art6.pdf |
| work_keys_str_mv | AT mihaelasabrinaherdea caplacizumabinthetreatmentofpatientswithrecurrentthromboticthrombocytopenicpurpurattp AT adelasaraionescu caplacizumabinthetreatmentofpatientswithrecurrentthromboticthrombocytopenicpurpurattp AT oanapatrinoiu caplacizumabinthetreatmentofpatientswithrecurrentthromboticthrombocytopenicpurpurattp AT mihaelaandreescu caplacizumabinthetreatmentofpatientswithrecurrentthromboticthrombocytopenicpurpurattp |