Prevalence and prognostic impact of cognitive frailty in elderly patients with heart failure: sub‐analysis of FRAGILE‐HF
Abstract Aims Although evidence suggests that cognitive decline and physical frailty in elderly patients with heart failure (HF) are associated with prognosis, the impact of concurrent physical frailty and cognitive impairment, that is, cognitive frailty, on prognosis has yet to be fully investigate...
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| Format: | Article |
| Language: | English |
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Wiley
2022-06-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.13844 |
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| author | Shuhei Yamamoto Saeko Yamasaki Satoko Higuchi Kentaro Kamiya Hiroshi Saito Kazuya Saito Yuki Ogasahara Emi Maekawa Masaaki Konishi Takeshi Kitai Kentaro Iwata Kentaro Jujo Hiroshi Wada Takatoshi Kasai Hirofumi Nagamatsu Tetsuya Ozawa Katsuya Izawa Naoki Aizawa Akihiro Makino Kazuhiro Oka Shin‐ichi Momomura Nobuyuki Kagiyama Yuya Matsue |
| author_facet | Shuhei Yamamoto Saeko Yamasaki Satoko Higuchi Kentaro Kamiya Hiroshi Saito Kazuya Saito Yuki Ogasahara Emi Maekawa Masaaki Konishi Takeshi Kitai Kentaro Iwata Kentaro Jujo Hiroshi Wada Takatoshi Kasai Hirofumi Nagamatsu Tetsuya Ozawa Katsuya Izawa Naoki Aizawa Akihiro Makino Kazuhiro Oka Shin‐ichi Momomura Nobuyuki Kagiyama Yuya Matsue |
| author_sort | Shuhei Yamamoto |
| collection | DOAJ |
| description | Abstract Aims Although evidence suggests that cognitive decline and physical frailty in elderly patients with heart failure (HF) are associated with prognosis, the impact of concurrent physical frailty and cognitive impairment, that is, cognitive frailty, on prognosis has yet to be fully investigated. The current study sought to investigate the prevalence and prognostic impact of cognitive frailty in elderly patients with HF. Methods and results This study is a sub‐analysis of FRAGILE‐HF, a prospective multicentre observational study involving patients aged ≥65 years hospitalized for HF. The Fried criteria and Mini‐Cog were used to diagnose physical frailty and cognitive impairment, respectively. The association between cognitive frailty and the combined endpoint of mortality and HF rehospitalization within 1 year was then evaluated. Among the 1332 patients identified, 1215 who could be assessed using Mini‐Cog and the Fried criteria were included in this study. Among those included, 279 patients (23.0%) had cognitive frailty. During the follow‐up 1 year after discharge, 398 combined events were observed. Moreover, cognitive frailty was determined to be associated with a higher incidence of combined events (log‐rank: P = 0.0146). This association was retained even after adjusting for other prognostic factors (hazard ratio: 1.55, 95% confidence interval: 1.13–2.13). Furthermore, a sensitivity analysis using grip strength, short physical performance battery, and gait speed to determine physical frailty instead of the Fried criteria showed similar results. Conclusions This cohort study found that 23% of elderly patients with HF had cognitive frailty, which was associated with a 1.55‐fold greater risk for combined events within 1 year compared with patients without cognitive frailty. |
| format | Article |
| id | doaj-art-c4c726a1e982477eaf2023b3708fa52e |
| institution | Kabale University |
| issn | 2055-5822 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj-art-c4c726a1e982477eaf2023b3708fa52e2025-02-05T05:22:10ZengWileyESC Heart Failure2055-58222022-06-01931574158310.1002/ehf2.13844Prevalence and prognostic impact of cognitive frailty in elderly patients with heart failure: sub‐analysis of FRAGILE‐HFShuhei Yamamoto0Saeko Yamasaki1Satoko Higuchi2Kentaro Kamiya3Hiroshi Saito4Kazuya Saito5Yuki Ogasahara6Emi Maekawa7Masaaki Konishi8Takeshi Kitai9Kentaro Iwata10Kentaro Jujo11Hiroshi Wada12Takatoshi Kasai13Hirofumi Nagamatsu14Tetsuya Ozawa15Katsuya Izawa16Naoki Aizawa17Akihiro Makino18Kazuhiro Oka19Shin‐ichi Momomura20Nobuyuki Kagiyama21Yuya Matsue22Department of Rehabilitation Shinshu University Hospital Matsumoto JapanDepartment of Cardiovascular Medicine National Hospital Organization Matsumoto Medical Center Matsumoto JapanDepartment of Cardiovascular Medicine Shinshu University School of Medicine Matsumoto Matsumoto JapanDepartment of Rehabilitation, School of Allied Health Sciences Kitasato University Sagamihara JapanDepartment of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine 2‐1‐1 Hongo, Bunkyo‐ku Tokyo 113‐8421 JapanDepartment of Rehabilitation The Sakakibara Heart Institute of Okayama Okayama JapanDepartment of Nursing The Sakakibara Heart Institute of Okayama Okayama JapanDepartment of Cardiovascular Medicine Kitasato University School of Medicine Sagamihara JapanDivision of Cardiology Yokohama City University Medical Center Yokohama JapanDepartment of Cardiovascular Medicine National Cerebral and Cardiovascular Center Osaka JapanDepartment of Rehabilitation Kobe City Medical Center General Hospital Kobe JapanDepartment of Cardiology Nishiarai Heart Center Hospital Tokyo JapanDepartment of Cardiovascular Medicine, Saitama Medical Center Jichi Medical University Saitama JapanDepartment of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine 2‐1‐1 Hongo, Bunkyo‐ku Tokyo 113‐8421 JapanDepartment of Cardiology Tokai University School of Medicine Isehara JapanDepartment of Rehabilitation Odawara Municipal Hospital Odawara JapanDepartment of Rehabilitation Kasukabe Chuo General Hospital Kasukabe JapanDepartment of Cardiovascular Medicine, Nephrology and Neurology University of the Ryukyus Okinawa JapanRehabilitation Center Kitasato University Medical Center Kitamoto JapanDepartment of Rehabilitation Saitama Citizens Medical Center Saitama JapanSaitama Citizens Medical Center Saitama JapanDepartment of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine 2‐1‐1 Hongo, Bunkyo‐ku Tokyo 113‐8421 JapanDepartment of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine 2‐1‐1 Hongo, Bunkyo‐ku Tokyo 113‐8421 JapanAbstract Aims Although evidence suggests that cognitive decline and physical frailty in elderly patients with heart failure (HF) are associated with prognosis, the impact of concurrent physical frailty and cognitive impairment, that is, cognitive frailty, on prognosis has yet to be fully investigated. The current study sought to investigate the prevalence and prognostic impact of cognitive frailty in elderly patients with HF. Methods and results This study is a sub‐analysis of FRAGILE‐HF, a prospective multicentre observational study involving patients aged ≥65 years hospitalized for HF. The Fried criteria and Mini‐Cog were used to diagnose physical frailty and cognitive impairment, respectively. The association between cognitive frailty and the combined endpoint of mortality and HF rehospitalization within 1 year was then evaluated. Among the 1332 patients identified, 1215 who could be assessed using Mini‐Cog and the Fried criteria were included in this study. Among those included, 279 patients (23.0%) had cognitive frailty. During the follow‐up 1 year after discharge, 398 combined events were observed. Moreover, cognitive frailty was determined to be associated with a higher incidence of combined events (log‐rank: P = 0.0146). This association was retained even after adjusting for other prognostic factors (hazard ratio: 1.55, 95% confidence interval: 1.13–2.13). Furthermore, a sensitivity analysis using grip strength, short physical performance battery, and gait speed to determine physical frailty instead of the Fried criteria showed similar results. Conclusions This cohort study found that 23% of elderly patients with HF had cognitive frailty, which was associated with a 1.55‐fold greater risk for combined events within 1 year compared with patients without cognitive frailty.https://doi.org/10.1002/ehf2.13844FrailtyCognitive impairmentHeart failureElderlyPrognosis |
| spellingShingle | Shuhei Yamamoto Saeko Yamasaki Satoko Higuchi Kentaro Kamiya Hiroshi Saito Kazuya Saito Yuki Ogasahara Emi Maekawa Masaaki Konishi Takeshi Kitai Kentaro Iwata Kentaro Jujo Hiroshi Wada Takatoshi Kasai Hirofumi Nagamatsu Tetsuya Ozawa Katsuya Izawa Naoki Aizawa Akihiro Makino Kazuhiro Oka Shin‐ichi Momomura Nobuyuki Kagiyama Yuya Matsue Prevalence and prognostic impact of cognitive frailty in elderly patients with heart failure: sub‐analysis of FRAGILE‐HF ESC Heart Failure Frailty Cognitive impairment Heart failure Elderly Prognosis |
| title | Prevalence and prognostic impact of cognitive frailty in elderly patients with heart failure: sub‐analysis of FRAGILE‐HF |
| title_full | Prevalence and prognostic impact of cognitive frailty in elderly patients with heart failure: sub‐analysis of FRAGILE‐HF |
| title_fullStr | Prevalence and prognostic impact of cognitive frailty in elderly patients with heart failure: sub‐analysis of FRAGILE‐HF |
| title_full_unstemmed | Prevalence and prognostic impact of cognitive frailty in elderly patients with heart failure: sub‐analysis of FRAGILE‐HF |
| title_short | Prevalence and prognostic impact of cognitive frailty in elderly patients with heart failure: sub‐analysis of FRAGILE‐HF |
| title_sort | prevalence and prognostic impact of cognitive frailty in elderly patients with heart failure sub analysis of fragile hf |
| topic | Frailty Cognitive impairment Heart failure Elderly Prognosis |
| url | https://doi.org/10.1002/ehf2.13844 |
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