Community-based prevalence versus hospital-based incidence of genital Human Papillomavirus infection in Central Vietnam
Introduction: This study aims to determine the genital HPV prevalence in reproductive-age women in Thua Thien Hue Province and comparison with HPV incidence in Hue University Hospital, Vietnam. Methodology: Cross-sectional study on 1,034 women of reproductive age from 11 communes/wards of three...
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The Journal of Infection in Developing Countries
2018-07-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/10297 |
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| author | Vu Quoc Huy Nguyen Viet Quynh Tram Ngo Minh Tam Le Hoang Bach Nguyen Van Bao Thang Phan Quang Vinh Truong Ngoc Thanh Cao Piero Cappuccinelli |
| author_facet | Vu Quoc Huy Nguyen Viet Quynh Tram Ngo Minh Tam Le Hoang Bach Nguyen Van Bao Thang Phan Quang Vinh Truong Ngoc Thanh Cao Piero Cappuccinelli |
| author_sort | Vu Quoc Huy Nguyen |
| collection | DOAJ |
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Introduction: This study aims to determine the genital HPV prevalence in reproductive-age women in Thua Thien Hue Province and comparison with HPV incidence in Hue University Hospital, Vietnam.
Methodology: Cross-sectional study on 1,034 women of reproductive age from 11 communes/wards of three districts representing three different geographic areas of Thua Thien Hue Province, Vietnam. The hospital-based group included 102 women with cervicitis and/or abnormal Pap smear result coming to Hue University Hospital. Extracting DNA from cervical samples, performing the real-time PCR for detecting HPV and the reverse dot-blot assay for HPV typing in HPV positive cases.
Results: In community, HPV prevalence was 0.9%. Mean-age of HPV positive group was 37.9 ± 6.2 years. The detected low-risk types were 6 and 11; high-risk types include 16, 18, 33, 45, 52, and 58. Single-type infection was found in 66.7% of cases. In hospital-based group, 41.2% of women have been infected with HPV, 6 different HPV types were detected. HPV18 was the most frequent high-risk type (33.3%), followed by HPV16 (15.1%); HPV6 was the most frequent among low-risk HPV types (31.2%). Single-type infection rate was 33,3%; 2 and 3 types co-infections were 28,6% and 38.1%, respectively.
Conclusions: Routine screening of high-risk HPV infection in women with symptomatic gynecologic infection and/or abnormal Pap smear appears to be benefit in early detection and prevention of cervical cancer, due to the high incidence of HPV infection.
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| format | Article |
| id | doaj-art-c4c2ec12b1784ffb99584ed8a2c067cb |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2018-07-01 |
| publisher | The Journal of Infection in Developing Countries |
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| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-c4c2ec12b1784ffb99584ed8a2c067cb2025-08-20T03:52:41ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802018-07-01120710.3855/jidc.10297Community-based prevalence versus hospital-based incidence of genital Human Papillomavirus infection in Central VietnamVu Quoc Huy Nguyen0Viet Quynh Tram Ngo1Minh Tam Le2Hoang Bach Nguyen3Van Bao Thang Phan4Quang Vinh Truong5Ngoc Thanh Cao6Piero Cappuccinelli7Hue University of Medicine and Pharmacy, Hue University, Hue, Viet NamHue University of Medicine and Pharmacy, Hue University, Hue, Viet NamHue University of Medicine and Pharmacy, Hue University, Hue, Viet NamHue University of Medicine and Pharmacy, Hue University, Hue, Viet NamHue University of Medicine and Pharmacy, Hue University, Hue, Viet NamHue University of Medicine and Pharmacy, Hue University, Hue, Viet NamHue University of Medicine and Pharmacy, Hue University, Hue, Viet NamHue University of Medicine and Pharmacy, Hue University, Hue, Viet Nam Introduction: This study aims to determine the genital HPV prevalence in reproductive-age women in Thua Thien Hue Province and comparison with HPV incidence in Hue University Hospital, Vietnam. Methodology: Cross-sectional study on 1,034 women of reproductive age from 11 communes/wards of three districts representing three different geographic areas of Thua Thien Hue Province, Vietnam. The hospital-based group included 102 women with cervicitis and/or abnormal Pap smear result coming to Hue University Hospital. Extracting DNA from cervical samples, performing the real-time PCR for detecting HPV and the reverse dot-blot assay for HPV typing in HPV positive cases. Results: In community, HPV prevalence was 0.9%. Mean-age of HPV positive group was 37.9 ± 6.2 years. The detected low-risk types were 6 and 11; high-risk types include 16, 18, 33, 45, 52, and 58. Single-type infection was found in 66.7% of cases. In hospital-based group, 41.2% of women have been infected with HPV, 6 different HPV types were detected. HPV18 was the most frequent high-risk type (33.3%), followed by HPV16 (15.1%); HPV6 was the most frequent among low-risk HPV types (31.2%). Single-type infection rate was 33,3%; 2 and 3 types co-infections were 28,6% and 38.1%, respectively. Conclusions: Routine screening of high-risk HPV infection in women with symptomatic gynecologic infection and/or abnormal Pap smear appears to be benefit in early detection and prevention of cervical cancer, due to the high incidence of HPV infection. https://jidc.org/index.php/journal/article/view/10297HPVgenital tract infectionreal-time PCRReverse dot-blot |
| spellingShingle | Vu Quoc Huy Nguyen Viet Quynh Tram Ngo Minh Tam Le Hoang Bach Nguyen Van Bao Thang Phan Quang Vinh Truong Ngoc Thanh Cao Piero Cappuccinelli Community-based prevalence versus hospital-based incidence of genital Human Papillomavirus infection in Central Vietnam Journal of Infection in Developing Countries HPV genital tract infection real-time PCR Reverse dot-blot |
| title | Community-based prevalence versus hospital-based incidence of genital Human Papillomavirus infection in Central Vietnam |
| title_full | Community-based prevalence versus hospital-based incidence of genital Human Papillomavirus infection in Central Vietnam |
| title_fullStr | Community-based prevalence versus hospital-based incidence of genital Human Papillomavirus infection in Central Vietnam |
| title_full_unstemmed | Community-based prevalence versus hospital-based incidence of genital Human Papillomavirus infection in Central Vietnam |
| title_short | Community-based prevalence versus hospital-based incidence of genital Human Papillomavirus infection in Central Vietnam |
| title_sort | community based prevalence versus hospital based incidence of genital human papillomavirus infection in central vietnam |
| topic | HPV genital tract infection real-time PCR Reverse dot-blot |
| url | https://jidc.org/index.php/journal/article/view/10297 |
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