A Mixed Gonadal Dysgenesis in an 19 Year Old Girl with Ambigous Genitalia: A Case Report

A 19-year-old girl was referred with delayed puberty and ambiguous genitalia. She had short stature with high blood pressure and Turner’s stigmata with external genitalia Prader Score 4. Ultrasound revealed hypoplastic uterus with no gonad. Follicle stimulating hormone, luteinizing hormone and testo...

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Main Authors: Amanda Trixie Hardigaloeh, Tri Juli Edi Tarigan, Em Yunir, Kanadi Sumapradja, Feranindhya Agiananda, Yulia Ariani, Nanis S Marzuki, Irfan Wahyudi, Lisnawati Lisnawati
Format: Article
Language:English
Published: Interna Publishing 2024-01-01
Series:Acta Medica Indonesiana
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Online Access:http://www.actamedindones.org/index.php/ijim/article/view/2271
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author Amanda Trixie Hardigaloeh
Tri Juli Edi Tarigan
Em Yunir
Kanadi Sumapradja
Feranindhya Agiananda
Yulia Ariani
Nanis S Marzuki
Irfan Wahyudi
Lisnawati Lisnawati
author_facet Amanda Trixie Hardigaloeh
Tri Juli Edi Tarigan
Em Yunir
Kanadi Sumapradja
Feranindhya Agiananda
Yulia Ariani
Nanis S Marzuki
Irfan Wahyudi
Lisnawati Lisnawati
author_sort Amanda Trixie Hardigaloeh
collection DOAJ
description A 19-year-old girl was referred with delayed puberty and ambiguous genitalia. She had short stature with high blood pressure and Turner’s stigmata with external genitalia Prader Score 4. Ultrasound revealed hypoplastic uterus with no gonad. Follicle stimulating hormone, luteinizing hormone and testosterone level were increased (51.29 mIU/mL, 23.66 mIU/mL and 742 ng/dl). Karyotyping revealed 46 XY with Fluorescence in situ hybridization cytogenetic study based on 300 cells showed mosaic chromosome, monosomy X (17%) and XY (83%). Laparascopic gonadectomy was done and showed that testes were only in the right inguinal canal. Then patient had external genitalia reconstruction and received estrogen replacement therapy.
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issn 0125-9326
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publishDate 2024-01-01
publisher Interna Publishing
record_format Article
series Acta Medica Indonesiana
spelling doaj-art-c4c2ba6a37644595ae8c2c0fdd7c7f2a2025-08-20T02:37:16ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322024-01-01554A Mixed Gonadal Dysgenesis in an 19 Year Old Girl with Ambigous Genitalia: A Case ReportAmanda Trixie Hardigaloeh0Tri Juli Edi Tarigan1Em Yunir2Kanadi Sumapradja3Feranindhya Agiananda4Yulia Ariani5Nanis S Marzuki6Irfan Wahyudi7Lisnawati Lisnawati8Division of Endocrinology, Metabolism, and Diabetes, Departement of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDivision of Endocrinology, Metabolism, and Diabetes, Departement of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDivision of Endocrinology, Metabolism, and Diabetes, Departement of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Obstetric Gynecologist, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Physiciatris, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Biology, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaEijkman Institute for Molecular Biology, Jakarta, IndonesiaDepartment of Urologist, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaDepartment of Pathology, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaA 19-year-old girl was referred with delayed puberty and ambiguous genitalia. She had short stature with high blood pressure and Turner’s stigmata with external genitalia Prader Score 4. Ultrasound revealed hypoplastic uterus with no gonad. Follicle stimulating hormone, luteinizing hormone and testosterone level were increased (51.29 mIU/mL, 23.66 mIU/mL and 742 ng/dl). Karyotyping revealed 46 XY with Fluorescence in situ hybridization cytogenetic study based on 300 cells showed mosaic chromosome, monosomy X (17%) and XY (83%). Laparascopic gonadectomy was done and showed that testes were only in the right inguinal canal. Then patient had external genitalia reconstruction and received estrogen replacement therapy. http://www.actamedindones.org/index.php/ijim/article/view/2271mixed gonadal dysgenesisambiguous genitalia
spellingShingle Amanda Trixie Hardigaloeh
Tri Juli Edi Tarigan
Em Yunir
Kanadi Sumapradja
Feranindhya Agiananda
Yulia Ariani
Nanis S Marzuki
Irfan Wahyudi
Lisnawati Lisnawati
A Mixed Gonadal Dysgenesis in an 19 Year Old Girl with Ambigous Genitalia: A Case Report
Acta Medica Indonesiana
mixed gonadal dysgenesis
ambiguous genitalia
title A Mixed Gonadal Dysgenesis in an 19 Year Old Girl with Ambigous Genitalia: A Case Report
title_full A Mixed Gonadal Dysgenesis in an 19 Year Old Girl with Ambigous Genitalia: A Case Report
title_fullStr A Mixed Gonadal Dysgenesis in an 19 Year Old Girl with Ambigous Genitalia: A Case Report
title_full_unstemmed A Mixed Gonadal Dysgenesis in an 19 Year Old Girl with Ambigous Genitalia: A Case Report
title_short A Mixed Gonadal Dysgenesis in an 19 Year Old Girl with Ambigous Genitalia: A Case Report
title_sort mixed gonadal dysgenesis in an 19 year old girl with ambigous genitalia a case report
topic mixed gonadal dysgenesis
ambiguous genitalia
url http://www.actamedindones.org/index.php/ijim/article/view/2271
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